Podofilox-Podophyllotoxin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPodofiloxCat. No.: HY-15552CAS No.: 518-28-5Synonyms: Podophyllotoxin分式: CHO分量: 414.41作靶點(diǎn): Microtubule/Tubulin作通路: Cell Cycle/DNA Damage; Cytoskeleton儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)

2、驗(yàn) DMSO : 100 mg/mL (241.31 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.4131 mL 12.0653 mL 24.1307 mL5 mM 0.4826 mL 2.4131 mL 4.8261 mL10 mM 0.2413 mL 1.2065 mL 2.4131 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清

3、的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.03 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.03 mM); Clear solution1/2 Maste

4、r of Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.03 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Podofilox (Podophyllotoxin)是微管組裝和DNA拓?fù)洚悩?gòu)酶II抑制劑。IC50 & Target Topoisomerase II; Microtubule/Tubulin體外研究 Podophyllotoxin, a kind of non-alkaloid toxin lignan

5、 extracted from the roots and rhizomes of Podophyllumplant, has been shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural productthat inhibits the polymerization of tubulin and has served as a prototype for the development of diverseantitumor agents in clinical use.RE

6、FERENCES1. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J ChinMed. 2013;41(1):163-75.2. Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan31.3

7、. Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMCComplement Altern Med. 2012 Dec 22;12:263.4. Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J ProteinChem. 1998 Oct;17(7):663-8.5. PodophyllotoxinMcePdfHeightCaution: Product has not been fully validated for medical applications.For researc