醫(yī)學(xué)免疫學(xué)英文版課件：Chapter15 immune regulation

1、Chapter17 ImmunoregulationImmunoregulation The ability of the immune system to control and regulate its own responses is called immunoregulation.Part Immuno-regulation on genetic levelPart Immuno-regulation on molecular levelPart Immuno-regulation on cellular levelPartIV Immuno-regulation on individ

2、ual levelContentsPart Regulation on genetic levelGenes encode TCR and BCRGenes encode molecules regulating immune response: MHCPart Immunoregulation on molecular level1. Regulation of antigen to Ir2.Regulation of antibody and Ag-Ab complex to Irantibody feedback inhibition: FcrR IIBCR BCR Antibody F

3、eedback Inhibition ITIMAgAgantibody feedback inhibition:II. The idiotypic networks and immunologic regulationIdiotopic determinant or idiotype: a unique determinant on an antibody or TCR molecule,usually formed by one or more of the hypervariable regions.Idiotopic determinant may be recognized as “f

4、oreign” in an individual because they are usually present in quantities too low to induce self-tolerance.anti-idiotypic antibody (or TCR): antibodies against idiotype of antibodies or TCRs3. Regulation of complements to activation of B cellsCR24. Regulation of the receptor of co-stimulatory molecule

5、sI. Active receptor and inhibitory receptor on immunocyte Immunocyte active receptor inhibitory receptor B cell BCR FcRII-B T cell TCR/CD28 CTLA4, KIR NK cell KAR KIR Mast cell FcR1 FcRII-BB 細(xì)胞抑制性受體（1/2）B 細(xì)胞抑制性受體（2/2）II. The regulation of signal transduction 1. ITAMs and ITIMs ITAM transducts a acti

6、ve signal ITIM transdcts a inhibitory signal2. Phosphorylation and dephosphorylation 3. Protein kinase and protein phosphatasePTK(ZAP-70) and PTP(SHP-1)Part The immunoloregulation on cellular level1. Regulation of T cell subsets2. Regulation of B cells 3. AICD (activation induced cell death)1.The im

7、munoregulation of T cell subsets Th1 cells promote the cellular immunity suppressing the humoral immunity. Th2 cells promote the humoral immunity suppressing the cellular immunity.Th1+IL-12+IL-4IL-2 IFN-gIL-4 IL-10 inhibitCell mediated immunityHumoral immunityTh0Th2 Th1 和 Th2 細(xì) 胞 的 分 化3. activation-

8、induced cell death（AICD）apoptosis of target cell :FasL on Tc binds to Fas on target cells-induce the apoptosis of target cellApoptosis of activated T cellsFas is expressed on activated TcFasL on activated T cell binds to Fas on activated T cell and then induces T cell apoptosis.Part IV The immunoregulation on systemic levelI. Nerve-endocrine -immune