HA-100 - PKA 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHA-100Cat. No.: HY-100984CAS No.: 84468-24-6分式: CHNOS分量: 277.34作靶點(diǎn): PKA; PKC; Myosin作通路: Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; Epigenetics;TGF-beta/Smad; Cytoskeleton儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 mont

2、hs-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 150 mg/mL (540.85 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.6057 mL 18.0284 mL 36.0568 mL5 mM 0.7211 mL 3.6057 mL 7.2114 mL10 mM 0.3606 mL 1.8028 mL 3.6057 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙?/p>

3、案，配制前請(qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.01 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.01 mM); Clear soluti

4、on3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (9.01 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 HA-100cGMP 依賴(lài)性蛋激酶 (PKG)，cAMP 依賴(lài)性蛋激酶 (PKA)，蛋激酶 C (PKC) 和 MLC 激酶 (MLC-kinase) 的抑制劑，其 IC50 值分別為 4, 8, 12 和 240 M。IC50 & Target PKC PKG PKA MLCK12 M

5、 (IC50) 4 M (IC50) 8 M (IC50) 240 M (IC50)REFERENCES1. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors,isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58