GW-766994-GW-994-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGW 766994Cat. No.: HY-107051CAS No.: 408303-43-5Synonyms: GW 994分式: CHClNO分量: 451.35作靶點(diǎn): CCR作通路: GPCR/G Protein; Immunology/Inflammation儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 56 mg

2、/mL (124.07 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.2156 mL 11.0779 mL 22.1558 mL5 mM 0.4431 mL 2.2156 mL 4.4312 mL10 mM 0.2216 mL 1.1078 mL 2.2156 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)

3、現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.33 mg/mL (5.16 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.33 mg/mL (5.16 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master

4、 of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.33 mg/mL (5.16 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 GW 766994趨化因受體-3 (chemokine receptor-3) 拮抗劑，已經(jīng)進(jìn)臨床階段，研究哮喘和嗜酸性管炎。IC50 & Target CCR37.86 (pKi)體外研究 GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical tri

5、al for asthmaand eosinophilic bronchitis 1. GW 766994 (10 M) reverses CCL11-induced activation of CDK5,phosphorylations of CDK5, GSK3, and increased phosphorylation of tau in hippocampal neurons 2.REFERENCES1. Neighbour H, et al. Safety and efficacy of an oral CCR3 antagonist in patients with asthma

6、 and eosinophilic bronchitis: a randomized,placebo-controlled clinical trial. Clin Exp Allergy. 2014 Apr;44(4):508-16.2. Zhu C, et al. Targeting CCR3 to Reduce Amyloid- Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model ofAlzheimers Disease. Mol Neurobiol. 2017 Dec;54(10):7964-7978.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 40