L-Epinephrine-minus-Epinephrine-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL-EpinephrineCat. No.: HY-B0447BCAS No.: 51-43-4Synonyms: (-)-Epinephrine; L-Adrenaline; (-)-Adrenalin分式: CHNO分量: 183.2作靶點: Adrenergic Receptor; Endogenous Metabolite作通路: GPCR/G Protein; Neuronal Signaling; MetabolicEnzyme/Prote

2、ase儲存式: 4C, protect from light, stored under nitrogen* 該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)現(xiàn)配，即刻使。溶解性數(shù)據(jù)體外實驗 DMSO : 2.22 mg/mL (12.12 mM; Need ultrasonic)H2O : 2 mg/mL (10.92 mM; ultrasonic and adjust pH to 2 with HCl)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 5.4585 mL 27.2926 mL 54.5852 mL5 mM 1.0917 mL 5.4585

3、 mL 10.9170 mL10 mM 0.5459 mL 2.7293 mL 5.4585 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)現(xiàn)配，即刻使。BIOLOGICAL ACTIVITY物活性 L-Epinephrine是由腎上腺髓質(zhì)分泌的激素。它是-adrenergic和-adrenergic受體激動劑。IC50 & Target Human Endogenous Metabolite體內(nèi)研究A 25 microliter volume of a 1-% L-epinephrine borate solution applied on t

4、he cornea of one eye in 121/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEmonkeys reduces blood flow through the iris and the ciliary body by 59% and 20%, respectively, compared tothe untreated control eyes 1. Epinephrine is a direct-acting sympathomimetic -adrenergic and -adrenergicagonist with cy

5、clic adenosine monophosphate-mediated, complex, bidirectional pharmacologic effects onmany target organs 2. In young adult rats, endogenous release of epinephrine facilitates stable memoryformation for temporally associated events. Epinephrine enhances memory in young adult rats, in part, byincreasi

6、ng blood glucose levels needed to modulate memory 3. Epinephrine is the primary drugadministered during cardiopulmonary resuscitation (CPR) to reverse cardiac arrest. Epinephrine increasesarterial blood pressure and coronary perfusion during CPR via alpha-1-adrenoceptor agonist effects 4.PROTOCOLAni

7、mal Rats: For the immunohistochemistry experiments, rats receive an immediate post-training subcutaneousAdministration 3 injection of saline (0.9%), glucose (250 mg/kg), or epinephrine (0.1 mg/kg) and are then returned to theholding cage 3.MCE has not independently confirmed the accuracy of these me

8、thods. They are for reference only.戶使本產(chǎn)品發(fā)表的科研獻 Int J Clin Exp Med. 2019;12(2):1640-1648.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Alm A, et al. The effect of topical l-epinephrine on regional ocular blood flow in monkeys. Invest Ophthalmol Vis Sci. 1980May;19(5):487-91.2.

9、 Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44.3. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-relatedmemory impairments. Exp Gerontol. 2013 Feb;48(2):115-27.4. Callaway CW, et al. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42.McePdfHeightCaution: Product has not been fully validated for