NKP608 - Neurokinin Receptor Antagonist - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENKP608Cat. No.: HY-18006CAS No.: 177707-12-9分式: CHClFNO分量: 619.98作靶點(diǎn): Neurokinin Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (16

2、1.30 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.03 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.03 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 NKP608為肽類4-氨哌啶衍物，是神經(jīng)激肽-1（NK-1）受體拮抗劑

3、，IC50為2.6 nM。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Biol Res. 2018 May 30;51(1):14.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. El-Hashim AZ, Wyss D, Lewis C. Effect of a novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airwayobstruction. Pulm Pharmacol Ther. 2004;17(1

4、):11-8.2. Vendruscolo LF, Takahashi RN, Brske GR, Ramos A. Evaluation of the anxiolytic-like effect of NKP608, a NK1-receptor antagonist, intwo rat strains that differ in anxiety-related behaviors. Psychopharmacology (Berl). 2003 Nov;170(3):287-93.3. Rupniak NM, Carlson EJ, Shepheard S, et al. Compa

5、rison of the functional blockade of rat substance P (NK1) receptors by GR205171,RP67580, SR140333 and NKP-608. Neuropharmacology. 2003 Aug;45(2):231-41.4. Gentsch C, Cutler M, Vassout A, et al. Anxiolytic effect of NKP608, a NK1-receptor antagonist, in the social investigation test in gerbils.Behav

6、Brain Res. 2002 Jul 18;133(2):363-8.5. Vassout A, Veenstra S, Hauser K, et al. NKP608: a selective NK-1 receptor antagonist with anxiolytic-like effects in the social interactionand social exploration test in rats. Regul Pept. 2000 Dec 22;96(1-2):7-16.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-