Ro-25-6981-Maleate - iGluR 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERo 25-6981 MaleateCat. No.: HY-13993ACAS No.: 1312991-76-6分式: CHNO分量: 455.54作靶點(diǎn): iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO

2、: 61 mg/mL (133.91 mM)H2O : 8.33 mg/mL (18.29 mM; ultrasonic and warming and heat to 45C)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.1952 mL 10.9760 mL 21.9520 mL5 mM 0.4390 mL 2.1952 mL 4.3904 mL10 mM 0.2195 mL 1.0976 mL 2.1952 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適

3、的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ro 25-6981是包含NR2B亞基的NMDA受體選擇性阻斷劑，對于重 組型NR1C/NR2B 和 NR1C/NR2A受體的IC50為0.009 和 52 M。REFERENCES1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. Fischer G, et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containi

4、ng the NR2B subunit.Characterization in vitro. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.2. Lynch DR, et al. Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. Eur J Pharmacol.2001 Mar 30;416(3):185-95.3. Jiang M, et al. Antinociception and preventio

5、n of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonistof the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895