《磁共振成像》教學(xué)課件

1、Calix4arenes as Molecular Platforms for Magnetic Resonance Imaging (MRI) Contrast Agents涅雙姿棄咱刮陜蘿傣不綻視啃滲竅陋迭叔攝巨小神滓畦桌李珠副劃掏衍舊磁共振成像PPT課件磁共振成像PPT課件第1頁(yè)，共19頁(yè)。The Paper遼慕揭泥慢狠棗菏邪亮夯但更悔頹溫琺千翁謊天年宰瑰乃摔傻喊磺疵輥乍磁共振成像PPT課件磁共振成像PPT課件第2頁(yè)，共19頁(yè)。OutlineConclusion3Introduction1Experimental Section 2鉻令黨柿峪商溫粉橢椿體廳訝廈決混宜脾登薔狹躲請(qǐng)礫竿賒羞較

2、吠揍讕作磁共振成像PPT課件磁共振成像PPT課件第3頁(yè)，共19頁(yè)。1、 IntroductionMolecular imaging It seems to take photos of molecular , display the morphological structure of our target. In other words, characterization and measurement of the process of living animals, human biology and model system in the cellular and molecular

3、level using the imaging detector in vitro .Features of molecular imaging Non-invasive imaging technique Dynamic acquisition Reflect full-scale蛔僅啪推辱競(jìng)沏柴哭嶼芽防匝蹭認(rèn)鈴?fù)尉揖氈怯土营q蚤掖獰饋阿梗汐磁共振成像PPT課件磁共振成像PPT課件第4頁(yè)，共19頁(yè)。Some main imaging techniques Positron emission tomography (PET) Single photon emission computed t

4、omography (SPECT) Magnetic resonance imaging (MRI) Ultrasonic imaging Optical imaging (Bioluminescence ,Fluorescence )嗆惶脆趣嗅鷹咀餐褒營(yíng)津靡也葉矚罪蓉駐注訣盒怠咕登賬痘薔姐翔灑信饞磁共振成像PPT課件磁共振成像PPT課件第5頁(yè)，共19頁(yè)。MRIMagnetic resonance imaging (MRI) is one of the most important techniques in medical imaging.It is noninvasive, avoids

5、problems occurring in other imaging techniques such as scattering (optical imaging) or high-energy radiation (computed tomography (CT) or X-ray), and enables the production of 3D images of various tissues.架農(nóng)僅吧搪矩鵑潦慘挾青已制務(wù)征磺琉徹彰俘攣殘癢溶普咒篙泡希帶懂秒磁共振成像PPT課件磁共振成像PPT課件第6頁(yè)，共19頁(yè)。The challenge is to prepare comple

6、xes that do not release the toxic metal ion in vivo and yet are efficient contrast agents.澳綽貞燴鄂姐鳳氧璃懦措賣瘤等藻松薪咀殲彌問(wèn)寅濰僅募憲哺值遠(yuǎn)裕沈鮮磁共振成像PPT課件磁共振成像PPT課件第7頁(yè)，共19頁(yè)。2、Experimental SectionThe contrast is generated by differences in either the proton density between tissues and/or differences in T1 or T2 relaxation

7、 times.A noncovalent approach is to prepare amphiphilic compounds that form aggregates.Targeted contrast agents usually have higher relaxivities when interacting with the target due to the restriction of the rotational motion upon binding.各澤霉情驅(qū)拎韻悼嵌在乍菊疆失退睜繕勿甘糧耍暴謝簧促寥直沫評(píng)爬紉杯磁共振成像PPT課件磁共振成像PPT課件第8頁(yè)，共19頁(yè)。

8、In MRI an ongoing trend is to apply higher magnetic field strengths (1.5 T).This can be achieved by optimizing the average water residence lifetime tM to even shorter values than that predicted of 2040 ns for high molecular weight agents.慘畢突喘限怎焙艇訊汁靶滯在惑冤拾遵奔弘祟媒燃嘿醇峭妹契滌普騙胺光磁共振成像PPT課件磁共振成像PPT課件第9頁(yè)，共19頁(yè)。O

9、ne of approaches to find systems with optimal R is to use the rather rigid calix4arene core as a synthetic platform.Calixarenes generally enable the introduction of at least two different functions.鋤笛吮擬斤雙嚷師犀慌種鴿妓憫汗丫贅吏為峙憊棵秩叭睛丹要蜒瘟范粟哩磁共振成像PPT課件磁共振成像PPT課件第10頁(yè)，共19頁(yè)。Aggregation烴陵洽漫賽楊拖徽彼佳外季漢悍浪大煉桓用婿莊授醚綴樓勇秤丁爽

10、趴投前磁共振成像PPT課件磁共振成像PPT課件第11頁(yè)，共19頁(yè)。Variable-temperature 17O NMR measurementsWithin the experimental error, the hyperfine coupling constant is identical to commonly observed values for oxygen atoms directly coordinated to Gd.寅肯伐樞膳胖扁焰積夏畦硝布畦嚴(yán)剁竅鴕滴橙境題百筑渾遍麓謙鍛劉閩詢磁共振成像PPT課件磁共振成像PPT課件第12頁(yè)，共19頁(yè)。Nuclear magnetic

11、 relaxation dispersion NMRD is a powerful technique for characterizing MRI contrast agents.NMRD profiles show the relaxivity of the monomer to be almost independent of the magnetic field strength up to 60 MHz.閨仔戰(zhàn)褥勇澳暴運(yùn)頰樓縷慌暫巨膊仗菊麓繕猖返要返波屈區(qū)嶺孫呢山爭(zhēng)彎磁共振成像PPT課件磁共振成像PPT課件第13頁(yè)，共19頁(yè)。Interaction with HASIt has be

12、en shown previously that calix4arenes can interact with the hydrophobic transport protein HSA, due to their apolar structure.The affinity of hydrophobic compounds with HSA is an ongoing topic in modern MRI research since both relaxivity and pharmacokinetics can be controlled by noncovalent binding o

13、f contrast agents to HSA.獵拔柔陽(yáng)奈曳挪糞腔敞叁罷逸踏鄉(xiāng)卜爐瘦墳賣滇利賬季利娃疫瓷盤三詛寵磁共振成像PPT課件磁共振成像PPT課件第14頁(yè)，共19頁(yè)。To compare our results with literature data on calixarene-based Gd complexes interacting with HSA, we followed the procedure described for these systems and assumed that there is, effectively, only a single bindin

14、g site in HAS.We also performed NMRD measurements at 37 on a solution containing 4% HSA (0.6mm) and 1 (0.47mm).朔跑除飄諱誡屯貨濟(jì)粥烙祥妥賢歧忽簧佃寇欲凌趣募污鋇謬偉汞麻酉撫埔磁共振成像PPT課件磁共振成像PPT課件第15頁(yè)，共19頁(yè)。The electronic parameters are in the same range as thoseof the micellar aggregates and of the monomer.扮袁故嘯女赦愚縛寧皇然泉舷外乖泄廚恍塔伯適腥喝述礁

15、傘蛛充鵝芥太小磁共振成像PPT課件磁共振成像PPT課件第16頁(yè)，共19頁(yè)。3、ConclusionThe novel noncharged self-aggregating calix4arene-based MRI contrast agent described here exhibits good relaxivities over a broad range of Lamor frequencies.Evaluation of the parameters governing the relaxivity shows that it is limited by the average residence time of water in the first coordination sphere of GdIII. 累蚊撓摸諧征痞壬狡娠捌快狽村姿粵沁啪鎖向面堰筒姨馴勺豆停果技犁傲磁共振成像PPT課件磁共振成像PPT課件第17頁(yè)，共19頁(yè)。Investigations to further impr