讀書(shū)報(bào)告會(huì)sci解讀5思維導(dǎo)圖實(shí)例lipid profiles and obesity as potential risk factors of sudden sensorineural hearing loss

1、主講：周權(quán)常德市第一人民醫(yī)院2017年1月28日血脂和肥胖是突發(fā)性耳聾的潛在危險(xiǎn)因素思維導(dǎo)圖SCI論文解讀系列Lipid Profiles and Obesity as Potential Risk Factors of Sudden Sensorineural Hearing Loss來(lái)自：Plos One 雜志，IF=3.057(2016年)文章全文在線網(wǎng)址： Objective: The objective of our study was to establish whether increased lipid profiles and obesity affect the preva

2、lence and prognosis of sudden sensorineural hearing loss (SSNHL).Method: This was a case-controlled study with a longitudinal design. According to our criteria, 324 patients with SSNHL were included in this study. To manage potential covariates, 972 subjects with normal hearing from the Korean Natio

3、nal Health and Nutrition Examination Survey were matched as control group according to their propensity scores. Age, level of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and body mass index (BMI) were obtained

4、 from the clinical data. Multivariate logistic regression analysis was used to investigate the association between SSNHL and lipid profiles or obesity in the 1296 subjects. Multivariate Cox regression analysis was used to determine whether lipid profiles and obesity are prognostic factors in patient

5、s with SSNHL.Results Mean body weight, BMI, TC, and TG were significantly higher in patients with SSNHL compared with control subjects (p0.05). However, LDL-C values did not differ significantly between the two groups. Subjects with elevated TC and TG levels had a 2.20- (95% CI 1.503.24) and 1.50-fo

6、ld (95% CI 1.082.08) increased odds, respectively, of SSNHL compared with subjects with normal TC and TG levels. Subjects with grade III BMI had a 1.59-fold (95% CI 1.172.16) increased odds of SSNHL. Multivariate Cox regression analyses revealed that BMI was an independent risk factor of treatment e, as patients with BMI 27.5 were less likely to achieve complete recovery than those with BMI 27.5 (p0.05).Conclusions The results of this study revealed that elevated TC and TG levels and increased BMI are significantly associated with the prevalence of SSNHL and its prognosis, indicating that vas