LY450108 - iGluR Activator - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELY450108Cat. No.: HY-10935CAS No.: 376594-67-1分式: CHFNOS分量: 396.45作靶點: iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 50 mg/mL

2、 (126.12 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.31 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.31 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL

3、(6.31 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 LY450108是AMPA受體增強劑。REFERENCES1. Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPAreceptors. British Journal of Pharmacology. 2010,160(2):181-190.2. ONeill MJ, Witkin JM. AMPA rec

4、eptor potentiators: application for depression and Parkinsons disease. Curr Drug Targets. 2007May;8(5):603-20.3. Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPAreceptor potentiators) and their concentration in cerebrospina

5、l fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.4. Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 AllostericallyRegulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02