Pseudoginsenoside-F11-Ginsenoside-A1-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPseudoginsenoside F11Cat. No.: HY-N0541CAS No.: 69884-00-0Synonyms: Ginsenoside A1分式: CHO分量: 801.01作靶點(diǎn): Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (124.84 mM

2、; Need ultrasonic)H2O : 0.67 mg/mL (0.84 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.2484 mL 6.2421 mL 12.4842 mL5 mM 0.2497 mL 1.2484 mL 2.4968 mL10 mM 0.1248 mL 0.6242 mL 1.2484 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添?/p>

3、助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (3.43 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (3.43 mM); Clear solution1/2 Master of Sma

4、ll Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (3.43 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Pseudoginsenoside F11 (Ginsenoside A1)西洋參的組成成分，能夠抵抗由莨菪堿、嗎啡、脫氧黃堿誘導(dǎo)的學(xué)習(xí)記憶能缺失。體外研究 Biochemical experiments revealed that Pseudoginsenoside F11 (Ginsenoside A1) could

5、inhibit diprenorphine(DIP) binding with an IC50 of 6.1 M and reduced the binding potency of morphine in Chinese hamster ovary(CHO)- cells 1.體內(nèi)研究 One in vivo model of cisplatin-induced acute renal failure was performed. The results showed thatpretreatment with Pseudoginsenoside Pseudoginsenoside F11

6、(Ginsenoside A1) reduced cisplatin-elevatedblood urea nitrogen and creatinine levels, as well as ameliorated the histophathological damage 1. Wetested the effects of Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) on morphine-induceddevelopment of behavioral sensitization and alterations in

7、 glutamate levels in the medial prefrontal cortex(mPFC) in freely moving mice by using in vivo microdialysis. As the results shown, PseudoginsenosidePseudoginsenoside F11 (Ginsenoside A1) antagonized the development of behavioral sensitization anddecrease of glutamate in the mPFC induced by morphine

8、 3.REFERENCES1. Wang H, et al. The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity invivo. Scientific Reports 2014, 4:49862. Li Zhu, et al. Pseudoginsenoside-F11 attenuates morphine-induced signalling in Chinese hamster ovary- cells. Ne

9、uroreport, 25 May2001 - Volume 12 - Issue 7 - pp 1453-14563. Yue Hao, et al. Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in themedial prefrontal cortex in mice. Pharmacology Biochemistry and BehaviorVolume 86, Issue 4, April 2007, Pages 660666McePdfHeightCaution: Product has not been fully validated for medi