Auxinole-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAuxinoleCat. No.: HY-111444CAS No.: 86445-22-9分式: CHNO分量: 321.37作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 125 mg/mL (388.96 mM)Ethanol : 12.5 mg/mL (38.90 mM; Ne

2、ed ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.1117 mL 15.5584 mL 31.1168 mL5 mM 0.6223 mL 3.1117 mL 6.2234 mL10 mM 0.3112 mL 1.5558 mL 3.1117 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍福渲魄罢埾扰渲瞥蔚膬湟海僖来翁砑又軇?為保證

3、實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.47 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.47 mM); Clear solution1/2 Master of Small Molec

4、ules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.47 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Auxinole種有效的 TIR1/AFB 受體植物激素拮抗劑，能夠與 TIR1 結(jié)合，阻 TIR1-IAA-Aux/IAA 復合物的形成，從抑制 auxin 應答因的表達。IC50 & Target TIR1/AFB receptor 1體外研究 Auxinole is a potent auxin antagonist of TIR1

5、/AFB receptors, and binds TIR1 to block the formation of theTIR1-IAA-Aux/IAA complex and then inhibits auxin-responsive gene expression. In addition, Auxinolecompetitively inhibits various auxin responses in planta 1. Auxinole causes reduction in IAA-triggereddepolarization in root hair cells. Auxin

6、ole (20M) also represses the transient increase in Ca2+cytcompletely, and blocks Ca2+ response 2.戶使本產(chǎn)品發(fā)表的科研獻 New Phytol. 2019 Jun 27.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Hayashi K, et al. Rational design of an auxin antagonist of the SCF(TIR1) auxin receptor complex. ACS Chem Biol. 2012 Mar16;7(3):590-8.2. Dindas J, et al. AUX1-mediated root hair auxin influx governs SCFTIR1/AFB-type Ca2+ signaling. Nat Commun. 2018 Mar 21;9(1):1174.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use onl