Hydrocortisone-cypionate - Glucocorticoid Receptor Agonist - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHydrocortisone cypionateCat. No.: HY-U00089CAS No.: 508-99-6分式: CHO分量: 486.64作靶點(diǎn): Glucocorticoid Receptor作通路: GPCR/G Protein儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (256.86

2、 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.0549 mL 10.2745 mL 20.5491 mL5 mM 0.4110 mL 2.0549 mL 4.1098 mL10 mM 0.2055 mL 1.0275 mL 2.0549 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲備

3、液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.27 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (4.27 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL

4、 (4.27 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Hydrocortisone cypionate種合成的糖質(zhì)激素和質(zhì)類醇酯。體外研究 Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells.Hydrocortisone supplementation of the serum-reduced cell diffe

5、rentiation medium leads to a significantincrease in TER across the hCMEC/D3 monolayer 1. Hydrocortisone-treated Dendritic cells (DCs) show adecreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific markerCD83, as well as a strongly reduced IL-12 secretion. Hydroc

6、ortisone-treated DCs inhibit production of IFN-but induce an increased release of IL-4 and no change in IL-5 2. Hydrocortisone reduces postischemicoxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemicshedding of syndecan-1, heparan sulfate, and hyaluron

7、an as is release of histamine from resident mast cells3.REFERENCES1. F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49.2. Bellinghausen I, et al. Inhibition of h

8、uman allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9.3. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007Nov;107(5):776-84.McePdfHeightCaution: Product has not been fully validated for medical application