Kainic-acid - Acids and Aldehyde - 生命科學試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEKainic acidCat. No.: HY-N2309CAS No.: 487-79-6分式: CHNO分量: 213.23作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H2O : 50 mg/mL (234.49 mM)* means soluble, but saturation unkn

2、own.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.6898 mL 23.4489 mL 46.8977 mL5 mM 0.9380 mL 4.6898 mL 9.3795 mL10 mM 0.4690 mL 2.3449 mL 4.6898 mL請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Kainic acidCNS 中興奮性氨酸受體亞型的有效激動劑。體內研究Kainic acid is a potent agonist at excitat

3、ory amino acid receptor subtypes in the CNS. HO-I levels aresignificantly enhanced one, three and seven days after i.c.v, injection of Kainic acid. One day after i.c.v,injection of Kainic acid, the HO-I protein level reaches a maximum and then decreases, but is stillsignificantly enhanced versus the

4、 vehicle-injected group. After i.c.v. injection of Kainic acid, HO-I-1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEimmunoreactivity is strongly induced not only in the CA3 but also widely in the whole hippocampus 1.PROTOCOLAnimal The rats are fasted over night with free access to water. For stere

5、otaxic injection, rats are anaesthetizedAdministration 1 (sodium pentobarbital, 50 mg/kg, i.p.) and immobilized in a Kopf stereotaxic frame. The rats are microinjectedwith 1 g Kainic acid in 2 L of sterilized physiological saline into the right lateral ventricle, i.e., 0.2 mmcaudal from the bregma,

6、1.2 mm right lateral and 3.8 mm ventral according to the rat brain atlas. For control,rats are injected with same amount (2 L) of vehicle, sterilized physiological saline. Five rats in each groupare used in this study 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Matsuoka Y, et al. Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience. 1998 Aug;85(4):1223-33.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.