Liraglutide - GLP-1 Receptor Agonist - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELiraglutideCat. No.: HY-P0014CAS No.: 204656-20-2分式: CHNO分量: 3751.26Sequence: His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-N 6-N-(1-oxohexadecyl)-L-Glutamyl-Glu-Gly-Gln-Ala-Ala-Lys -Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly

2、-Arg-GlySequence Shortening: HAEGTFTSDVSSYL-N6-N-(1-oxohexadecyl)-L-Etamyl-Glu-GQAAKEFIAWLVRGRG作靶點: Glucagon Receptor作通路: GPCR/G Protein儲存式: Protect from lightPowder -80C 2 years-20C 1 yearIn solvent -80C 6 months-20C 1 month* 該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)現(xiàn)配，即刻使。溶解性數(shù)據(jù)體外實驗 H2O : 5 mg/mL (1.33 mM; ultrasonic and a

3、djust pH to 8 with NaOH)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 0.2666 mL 1.3329 mL 2.6658 mL5 mM - - -10 mM - - -請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Liraglutide種胰糖素樣肽-1 (GLP-1) 受體激動劑，于治療 2 型糖尿病。IC50 & Target

4、GLP-1 receptor 1體外研究 Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1. Liraglutide is aninjectable drug for the treatment of type 2 diabetes, also can be used to treat obesity in adults with somerelated comorbidity. Liraglutide activated AMPK/SREBP1 pathway in o

5、xLDL-stimulated Raw264.7 cells 1.PROTOCOLCell Assay 1 Raw264.7 macrophage cells are cultured in Dulbeccos modified Eagles medium supplemented with 10%fetal bovine serum in a humidified 37C incubator with 5% CO2. The cells are incubated with oxLDL (50 g/mL), Liraglutide (0.1, 0.5, 1 and 2 nM) or Exen

6、din-3 (9-39) (1, 10 and 100 nM) alone, or in combination 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.戶使本產(chǎn)品發(fā)表的科研獻 Int J Mol Sci. 2019 Apr 2;20(7). pii: E1629. Mol Med Rep. 2016 Oct;14(4):3662-8.See more customer validations on HYPERLINK / www.MedCh

7、emEREFERENCES1. Wang Y,et al. Transformation of oligomers of lipidated peptide induced by change in pH.Mol Pharm. 2015 Feb 2;12(2):411-9.2. Wang YG, et al. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving theAMPK/SREBP1 pathway.J Geriatr Cardiol. 2015 Jul;12(4):410-416.McePdfHeightCaution: Product has not been fully validated for medical applications.For research