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1、精選文檔精選文檔PAGEPAGE5精選文檔PAGE.CURRICULUMVITAE,M.D.,Ph.D.Address:DepartmentofNeurology,lHospital,Beijing,P.R.ChinaPhone:E-mail:Researchobjectives:Vascularpathologyinstroke,GeneticresearchinCMT,FunctionalMRinstrokeIntra-arterial/venousthrombolysisinacutecerebralinfarctionCAREERAIMSShort-term:Toprocureapos
2、t-doctoralvacancyabroadfor1or2yearstobroadenmyview,toenhancemyskillsandtoacquiretheabilitytomeettherequirementofhigherstandardofwork.Myinterestsare:PathologyinADandVaDGeneticresearchinCMTandCADASILFunctionalMRinStrokeLong-term:TocooperatewithmoreexpertsandbecamemoreandmoreexpertinNeurological;resear
3、ch.EDUCATION2003-2006:Ph.D.inNeurology,TheUniversity,Chongqing,P.R.ChinaThesis:Advisor:Prof.Inthisstudy,I2000-2003:M.S.studiesinNeurology,TheUniversity,Chongqing,P.R.ChinaThesis:Advisor:Prof.Thisprojectistoanalysis1995-2000:M.D.inclinicalmedicine,TheUniversity,Chongqing,P.R.ChinaAPPOINTMENTS01/2009-
4、Present:Chief-Resident,DepartmentofNeurology,Hospital10/2007-Present:Instructor,Physician-in-charge,DepartmentofNeurology,Hospital10/2000-10/2007:Physician-resident,DepartmentofNeurology,HospitalHONORSANDAWARDS2007:ExcellentPhysician-resident,Hospital;2010:ExcellentChief-Resident,BeijingMilitaryGene
5、ralHospitalRESEARCHEXPERIENCEPrincipalinaprojectsupportedbytheNationalScienceFoundationofChina(Grant#30800357).Thisproject,whichwillbefinishedinJuly,2011,istostudytherelationshipbetweenphenotypeswitchofVSMCandNotch3.MainparticipatorinaprojectsupportedbyNationalScienceFoundationofChina(Grant#30470609
6、),Inthisproject,IhavefoundwhentheFLNmRNAinVSMCwassuppressedbyRNAi,theproliferationofVSMCwasdescendedandtheswitchfromContractilphenotypetoSyntheticphenotypewasblocked.ThisresultwillbepublishedinCellBiochemistryandBiophysics(IF:4.37)inafewmonths.Ihavefoundahugefamily(250persons,familytreeisinappendix)
7、ofCMT,butthemutationcanntbeidentifiedwithcommonmethod.Nowweusewhole-exonsequencingtoidentifiesthemutationsandtheresultwillcameoutinafewweeks.Ialsoamfamiliarwiththeprotocolofclinictrialandattendinsomeinternationalclinictrials.Theseinclude:PROFESS(PreventionRegimenforEffectivelyAvoidingSecondStrokes),
8、INTERACT(IntensiveBloodPressureReductioninAcuteCerebralHemorrhageTrial)ESPRIT(Europeanstrokepreventioninreversibleischemiatrial),CASTA(CerebrolysininpatientswithAcuteischemicStrokeinAsia),andetal.NowIamthememberoftheEthiccommitteeinmyhospital.SELECTEDPUBLICATIONS;PROFESSIONALAFFILIATIONSLABORATORYSK
9、ILLSIntensiveexperienceinNeuropathologyandneuroimaging.In2001,StudythemethodofNeuropathologyundertheProf.Magerittafor6months.ShewasaneurologistinDept.Neuropathology,UPSALAuniversity,Sweden.Intheperiod,Ilearnedthemethodofpathologyandneuropathology,includeofImmunohistochemistry,Immunofluorescence,insi
10、tuhybridizationandsoon.In2003,takepartinaneuropathologytrainingcourseholdbytheneuropathologicalbranchofCMAforonemonth.In2005and2009,takepartintheadvancedneuropathologytrainingcoursesforhalfamontheachtime.Afterthesecourses,Ilearnedthepathologicaldiagnosisofmanyneurologicaldiseases.In2009,takepartinth
11、eneuroimagingtrainingcourseholdbyneuroimagingbranchofCMAfor3months.ThiscoursewastostudytheMRIdiagnosisofneurologicaldisease,whichincludeofcerebralvasculardisease,cerebraltumorandDegeneration.canreadcerebralorspinalCTscansorMRscansandmakethediagnosisindependently.Iamfamiliarwiththeimagingchangesofcer
12、ebralinfarction,cerebralhemorrhage,MS,cerebralinfectiousdiseaseandcerebraltumors.Inmyclinicalpractice,Ihavediagnosedmanyintractablecasesbymyself,whichincludeofreversibleposteriorleukoencephalopathysyndrome(RPLES),Wernickesencephalopathy,CerebralVenousThrombosis,progressivesupranuclearpalsy(PSP),Creu
13、tzfeldtJakobdisease(CJD),cavernousmalformation,centralpontinemyelinolysis(CPM),extra-pontinemyelinolysis(EPM),gliomatosiscerebri,primarycentralnervoussystemlymphoma(PCNSL),Tolosa-Huntsyndrome,multiplesystematrophy(MSA),mitochondrialmyopathyandsoon.From2006tonow,IstudytheMRchangeandgeneticmutationofC
14、ADASIL.Ihad;gotmorethan10familiesofCADASIL.Morethan50personsinthesefamiliesweredetectedthemutationofgeneorsomechangeinMRimaging.Thearticlewillbefinishedinnomorethanoneyear.Familiarwithcommonmolecularbiologytechnology,includingPCRandRT-PaCR,SSCP,RFLP,genotyping,primerandprobedesign,plasmidpreparation,Liposometran
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