DBCO-acid-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDBCO-acidCat. No.: HY-42972CAS No.: 1353016-70-2分式: CHNO分量: 305.33作靶點: ADC Linker作通路: Antibody-drug Conjugate/ADC Related儲存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性數(shù)據(jù)體外實驗

2、DMSO : 100 mg/mL (327.51 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.2751 mL 16.3757 mL 32.7515 mL5 mM 0.6550 mL 3.2751 mL 6.5503 mL10 mM 0.3275 mL 1.6376 mL 3.2751 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性

3、，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.19 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.19 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilS

4、olubility: 2.5 mg/mL (8.19 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 DBCO-acid種可降解 (cleavable) ADC linker，可于合成 ADC linker DBCO-NHS ester (HY-115524 和HY-115545)，及偶聯(lián)物 DBCO-PEG-MMAE (HY-111012 和 HY-126690) 1。IC50 & Target CleavableREFERENCES1. Zimmerman

5、ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-freeexpression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58955