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AChromatinLandmarkandTranscriptionInitiationatMostPromotersinHumanCellVolume130,Issue1200777- FUDANEPIGENETICS 關(guān)于HistoneCode問題二：Histonecode可以自 嗎 FUDANEPIGENETICS TwopossiblewaystoinherithistoneHistonemarker FUDANEPIGENETICS FUDANEPIGENETICS FUDANEPIGENETICS II.II.組蛋白修飾 表達調(diào) FUDANEPIGENETICS 大部分賴氨酸位點均可以被?；；c轉(zhuǎn)錄激活正相AAAAAAAAAAAAAAAALysine催化位功H4(K5,H3(K14,K18)H4(K5,K8)H2A(K5)H2B(K12,5H3(K9,K14,H4(K5,K8,K12,K16)H3H4(K5,K8,ORCH4Metabolism,H3(K9,K14,K18)andmanyother FUDANEPIGENETICS Material:Macronuclei(EnrichedforHistoneacetylation)Assay:Enzyme+Histone+[3H]-Acteyl-coA=SignalAssaydoneinGelBrownellJE1995BrownellJE1996 FUDANEPIGENETICS MolecularCharacterizationofBrownellJE1996 FUDANEPIGENETICS GCN5是SAGA復(fù)合體的酶活組分，并與activatorGCN5在酵母內(nèi)?；?啟動其活性可促進nucleosomep300Sterner2000 FUDANEPIGENETICS Trapoxin微生物來源的天然化合物 WB:anti-HeLacellwholecellextractA:untreatedB:Treatedwith FUDANEPIGENETICS StuartTauntonJ,2000, FUDANEPIGENETICS StruhlK1998 FUDANEPIGENETICS Non-histoneKunliang

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