COQ7-IN-2-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECOQ7-IN-2Cat.No.:HY-138429CASNo.:2579696-76-5分?式:C??H??N?O分?量:251.28作?靶點:Others作?通路:Others儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:25mg/mL(99.49mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.9796mL19.8981mL39.7962mL5mM0.7959mL3.9796mL7.9592mL10mM0.3980mL1.9898mL3.9796mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(9.95mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性COQ7-IN-2(compound12)COQ7的抑制劑，對DMQ10和UQ10積聚的IC50值分別為7.3μM和15.4μM。體外研究COQ7-IN-2(compound12)haslessgrowthinhibitionagainsthumannormalculturecells[1].ThesubstantialDMQ10accumulationoccurredinbothPANC-1cells(8.7%byCOQ7-IN-2(compound12))andPC3cells(14.0%byCOQ7-IN-2(compound12))[1].REFERENCES[1].KeikoTsuganezawa,etal.IdentificationofsmallmoleculeinhibitorsofhumanCOQ7.BioorgMedChem.2020Jan1;28(1):115182.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax