NGB-2904-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENGB2904Cat.No.:HY-12697CASNo.:189060-98-8分?式:C??H??Cl?N?O分?量:494.46作?靶點(diǎn):DopamineReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲(chǔ)存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗(yàn)Ethanol:4.55mg/mL(9.20mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.0224mL10.1120mL20.2241mL5mM0.4045mL2.0224mL4.0448mL10mM---------請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性NGB2904?種具有?服活性和選擇性的多巴胺(DA)D3受體拮抗劑。NGB2904可?于可卡因成癮的研究[1]。IC50&TargetD3Receptor體內(nèi)研究NGB2904(0.1~5mg/kg;i.p.)significantlyloweresthebreak-pointforcocaineself-administrationbehaviorreinforcedunderprogressive-ratioconditionsandsignificantlyinhibitscocaine-triggeredreinstatementof1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEdrug-seekingbehaviorinratsextinguishedfromdailycocaineself-administration[1].NGB2904(0~10mg/kg;i.p.)administered30minpriortothebeginningofdailycocaineself-administrationsessionshasnosignificanteffectoncocaineself-administrationbehaviorataunitcocainereinforcementdoseof0.5mg/kg/infusioncomparedtovehicle-treatedanimals.NGB2904(0.1and1mg/kg)pretreatmentsignificantlyinhibitstheenhancedbrainstimulationrewardproducedby2mg/kg,butnotby10mg/kg,ofcocaine.NGB2904pretreatmentproducesasignificantattenuationofthiscocaine-triggeredreinstatementofdrug-seeking[1].AnimalModel:MaleLong–Evansrats(250–300g)[1]Dosage:0.1~5mg/kgAdministration:I.p.;Result:Significantlyloweredthebreak-pointforcocaineself-administrationbehaviorreinforcedunderprogressive-ratioconditionsandsignificantlyinhibitedcocaine-triggeredreinstatementofdrug-seekingbehaviorinratsextinguishedfromdailycocaineself-administration.REFERENCES[1].XiZX,etal.ThenoveldopamineD3receptorantagonistNGB2904inhibitscocaine'srewardingeffectsandcocaine-inducedreinstatementofdrug-seekingbehaviorinrats.Neuropsychopharmacology.2006;31(7):1393-1405.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearch