作用于GABA受體殺蟲劑藥理學課件

作用于GABA受體殺蟲劑藥理學作用于GABA受體殺蟲劑藥理學1第六章作用于GABA受體殺蟲劑●1、GABA-receptorogabay-aminobutyricacid)isatrueneurotransmitter.GABa'sroleisthatoftheprimaryinhibitoryneurotransmitterGABAachievesthisbyeffectingtheactionsoftheGABAreceptor,a5subunitiontransporter第六章作用于GABA受體殺蟲劑21.GABA-receptorre8-10amitan-Timmontoclosecl-channelirhibtactiVtyinc出competediredlywithGABAatthesamesiteEXPLODEDVIEVOFGABARECEPTORCOMPLEXEPTGABAAGAEARECEPTORS1.GABA-receptor31.GABA-receptorSABAopenCl-Channel31.GABA-receptor41.GABA-receptorBenzodiazepinesGAEA↑Muscimol↑1.GABA-receptor51.GABA-receptorGABAAReceptorComplexGABABorbltuatesETOH1.GABA-receptor61.GABA-receptoreWhengababindstothegabareceptor,thesubunitsofthereceptoropen"andthereisaninfluxofchlorideions.Thisinfluxrestorestheelectricalpotentialoftheneuronandtherebydecreasesthelikelihoodthattheneuronwilldepolarizeandrelaytheincomingsignal.Essentially,weakorirrelevantsignalsaremorelikelytobeterminatedor"ignored61.GABA-receptor72、fipronil2、銳勁特(regent,氟蟲腈fipronil)●法國羅納普朗克公司開發(fā)的苯并吡唑類殺蟲劑,中等毒性,以觸殺、胃毒為主,在水稻上內吸作用強,主要防水稻螟蟲、飛虱、薊馬、蚜蟲、小菜峨等,對有機磷和菊酯類殺蟲劑抗性害蟲的防治效果較好。2、fipronil82、fiproniloFipronilisahighlyactive,broad-spectruminsecticidefromthephenylpyrazole(吡唑)family.tcanbeusedagainstmajorlepidopterousandorthopterouspestsonawiderangeoffieldandhorticulturalcropsandagainstcoleopterouslarvaeinsoil.Itisalsoemployedforcockroachandantcontro82、fipronil92、fiproniloFipronilwasdiscoveredin1987andfirstauthorizedforagriculturalandno-agriculturalusein1993.Themajoradvantagesincludeabroadspectrumofactivity,lackofcrossresistancewithexistingcommercialproducts,andselectivityagainstpestspecles92、fipronil102、fiproniloThemechanismofactionforthisinsecticideappearstobetheblockageofthegABA-requlatedchloridechannel.Fipronilactsasaninsect-specificantagonistalteringchlorideionflux,resultingindisruptionofCNSactivityanddeathoftargetinsect102、fipronil11作用于GABA受體殺蟲劑藥理學課件12作用于GABA受體殺蟲劑藥理學課件13作用于GABA受體殺蟲劑藥理學課件14作用于GABA受體殺蟲劑藥理學課件15作用于GABA受體殺蟲劑藥理學課件16作用于GABA受體殺蟲劑藥理學課件17作用于GABA受體殺蟲劑藥理學課件18作用于GABA受體殺蟲劑藥理學課件19作用于GABA受體殺蟲劑藥理學課件20作用于GABA受體殺蟲劑藥理學課件21作用于GABA受體殺蟲劑藥理學課件22作用于GABA受體殺蟲劑藥理學課件23作用于GABA受體殺蟲劑藥理學課件24作用于GABA受體殺蟲劑藥理學課件25作用于GABA受體殺蟲劑藥理學課件26作用于GABA受體殺蟲劑藥理學課件27作用于GABA受體殺蟲劑藥理學課件28作用于GABA受體殺蟲劑藥理學課件29作用于GABA受體殺蟲劑藥理學課件30作用于GABA受體殺蟲劑藥理學課件31作用于GABA受體殺蟲劑藥理學課件32作用于GABA受體殺蟲劑藥理學課件33作用于GABA受體殺蟲劑藥理學課件34END16、業(yè)余生活要有意義，不要越軌?！A盛頓

17、一個人即使已登上頂峰，也仍要自強不息。——羅素·貝克

18、最大的挑戰(zhàn)和突破在于用人，而用人最大的突破在于信任人?！R云

19、自己活著，就是為了使別人過得更美好?！卒h

20、要掌握書，莫被書掌握；要為生而讀，莫為讀而生?！紶栁諩ND16、業(yè)余生活要有意義，不要越軌?！A盛頓35作用于GABA受體殺蟲劑藥理學作用于GABA受體殺蟲劑藥理學36第六章作用于GABA受體殺蟲劑●1、GABA-receptorogabay-aminobutyricacid)isatrueneurotransmitter.GABa'sroleisthatoftheprimaryinhibitoryneurotransmitterGABAachievesthisbyeffectingtheactionsoftheGABAreceptor,a5subunitiontransporter第六章作用于GABA受體殺蟲劑371.GABA-receptorre8-10amitan-Timmontoclosecl-channelirhibtactiVtyinc出competediredlywithGABAatthesamesiteEXPLODEDVIEVOFGABARECEPTORCOMPLEXEPTGABAAGAEARECEPTORS1.GABA-receptor381.GABA-receptorSABAopenCl-Channel31.GABA-receptor391.GABA-receptorBenzodiazepinesGAEA↑Muscimol↑1.GABA-receptor401.GABA-receptorGABAAReceptorComplexGABABorbltuatesETOH1.GABA-receptor411.GABA-receptoreWhengababindstothegabareceptor,thesubunitsofthereceptoropen"andthereisaninfluxofchlorideions.Thisinfluxrestorestheelectricalpotentialoftheneuronandtherebydecreasesthelikelihoodthattheneuronwilldepolarizeandrelaytheincomingsignal.Essentially,weakorirrelevantsignalsaremorelikelytobeterminatedor"ignored61.GABA-receptor422、fipronil2、銳勁特(regent,氟蟲腈fipronil)●法國羅納普朗克公司開發(fā)的苯并吡唑類殺蟲劑,中等毒性,以觸殺、胃毒為主,在水稻上內吸作用強,主要防水稻螟蟲、飛虱、薊馬、蚜蟲、小菜峨等,對有機磷和菊酯類殺蟲劑抗性害蟲的防治效果較好。2、fipronil432、fiproniloFipronilisahighlyactive,broad-spectruminsecticidefromthephenylpyrazole(吡唑)family.tcanbeusedagainstmajorlepidopterousandorthopterouspestsonawiderangeoffieldandhorticulturalcropsandagainstcoleopterouslarvaeinsoil.Itisalsoemployedforcockroachandantcontro82、fipronil442、fiproniloFipronilwasdiscoveredin1987andfirstauthorizedforagriculturalandno-agriculturalusein1993.Themajoradvantagesincludeabroadspectrumofactivity,lackofcrossresistancewithexistingcommercialproducts,andselectivityagainstpestspecles92、fipronil452、fiproniloThemechanismofactionforthisinsecticideappearstobetheblockageofthegABA-requlatedchloridechannel.Fipronilactsasaninsect-specificantagonistalteringchlorideionflux,resultingindisruptionofCNSactivityanddeathoftargetinsect102、fipronil46作用于GABA受體殺蟲劑藥理學課件47作用于GABA受體殺蟲劑藥理學課件48作用于GABA受體殺蟲劑藥理學課件49作用于GABA受體殺蟲劑藥理學課件50作用于GABA受體殺蟲劑藥理學課件51作用于GABA受體殺蟲劑藥理學課件52作用于GABA受體殺蟲劑藥理學課件53作用于GABA受體殺蟲劑藥理學課件54作用于GABA受體殺蟲劑藥理學課件55作用于GABA受體殺蟲劑藥理學課件56作用于GABA受體殺蟲劑藥理學課件57作用于GABA受體殺蟲劑藥理學課件58作用于GABA受體殺蟲劑藥理學課件59作用于GABA受體殺蟲劑藥理學課件60作用于GABA受體殺蟲劑藥理學課件61作用于GABA受體殺蟲劑藥理學課件62作用于GABA受體殺蟲劑藥理學課件63作用于GABA受體殺蟲劑藥理學課件64作用于GABA受體殺蟲劑藥理學課件65作用于GAB