Cidofovir-diphosphate-tri-triethylamine-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECidofovirdiphosphatetri(triethylamine)Cat.No.:HY-131606B分?式:C??H??N?O??P?分?量:742.72作?靶點(diǎn):Others作?通路:Others儲存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)H2O:250mg/mL(336.60mM;Needultrasonic)DMSO:125mg/mL(168.30mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.3464mL6.7320mL13.4640mL5mM0.2693mL1.3464mL2.6928mL10mM0.1346mL0.6732mL1.3464mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請?jiān)?個?內(nèi)使?，-20°C儲存時，請?jiān)?個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Cidofovirdiphosphatetritriethylamine西多福韋的細(xì)胞內(nèi)活性代謝物。diphosphatetritriethylamine是病毒DNA聚合酶的選擇性抑制劑，對HCMV，HSV-1和HSV-2的Ki值分別為6.6，0.86和1.4μM。體外研究Cidofovirdiphosphatetritriethylamine(0-1000μM)inhibitsHCMV,HSV-1,HSV-2,humanα,humanβandhumanγDNApolymerasewithKivaluesof6.6,0.86,1.4,51,520and300μM,respectively[1].Cidofovirdiphosphatetritriethylamine(0.3-30μM)inhibitsvacciniavirusDNApolymerasewithaKmvalueof23μM1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[2].REFERENCES[1].HitchcockMJM,etal.Cidofovir,aNewAgentwithPotentAnti-HerpesvirusActivity.1996.[2].MageeWC,etal.MechanismofinhibitionofvacciniavirusDNApolymerasebycidofovirdiphosphate.AntimicrobAgentsChemother.2005Aug;49(8):3153-62.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792