CBR-5884-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECBR-5884Cat.No.:HY-100012CASNo.:681159-27-3分?式:C??H??N?O?S?分?量:336.39作?靶點(diǎn):PhosphoglycerateDehydrogenase(PHGDH)作?通路:MetabolicEnzyme/Protease儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:50mg/mL(148.64mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.9727mL14.8637mL29.7274mL5mM0.5945mL2.9727mL5.9455mL10mM0.2973mL1.4864mL2.9727mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(6.18mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性CBR-5884?種有效，選擇性的磷酸?油酸脫氫酶(PHGDH)抑制劑，IC50為33μM。CBR-5884抑制癌細(xì)胞中的絲氨酸合成，并且對(duì)具有?絲氨酸?物合成活性的癌細(xì)胞系具有選擇性毒性。CBR-5884選擇性地抑制?素瘤和乳腺癌細(xì)胞系的增殖。IC50&TargetPHGDH,serinesynthesis[1]體外研究CBR-5884(15or30μM;3-5days)selectivelyinhibitstheproliferationofmelanomaandbreastcancerlinesthathaveahighpropensityforserinesynthesis.CellProliferationAssay[1]CellLine:BreastandmelanomacelllinesConcentration:15or30μMIncubationTime:3-5daysResult:Inhibitedtheproliferationofmelanomaandbreastcancerlines.戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?Immunity.2021Aug10;54(8):1728-1744.e7.?CellMetab.2021May4;33(5):971-987.e6.?CellMolImmunol.2022Nov;19(11):1263-1278.?JClinInvest.2020Jun1;130(6):3253-3269.?MolCell.2019Sep19;75(6):1147-1160.e5.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].EdouardMullarkyetal.Identificationofasmallmoleculeinhibitorof3-phosphoglyceratedehydrogenasetotargetserinebiosynthesisincancersProcNatlAcadSciUSA,2016Feb16,113(7):1778-83.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: