糖尿病對Modic改變的影響及臨床意義,臨床醫(yī)學(xué)碩士論文

糖尿病對Modic改變的影響及臨床意義,臨床醫(yī)學(xué)碩士論文摘要目的：探究糖尿病及相關(guān)指標(biāo)〔糖化血紅蛋白、糖尿病病程〕對Modic改變〔MC〕的影響，評估其能否為MC發(fā)生的危險(xiǎn)因素，并為預(yù)防MC發(fā)生提供新思路。方式方法：回首性的收集了在2020.01-2020.10期間于福建醫(yī)科大學(xué)附屬文章為碩士論文，如需全文請點(diǎn)擊底部下載全文鏈接】材料和方式方法1.1、研究對象1.2、納入與排除標(biāo)準(zhǔn)1.3、影像學(xué)檢查及評估1.4、糖尿病的診斷及相關(guān)指標(biāo)1.5、人口學(xué)資料分組1.6、統(tǒng)計(jì)學(xué)處理結(jié)果1.1、組間人口學(xué)、實(shí)驗(yàn)室、影像學(xué)數(shù)據(jù)比擬(病例匹配前)1.2、Modic改變和Pfirrmann分級(jí)的分布情況1.3、組間人口學(xué)、實(shí)驗(yàn)室、影像學(xué)數(shù)據(jù)比擬(病例匹配后)1.4、各椎間隙能否存在Modic改變與Pfirrmann分級(jí)關(guān)聯(lián)1.5、Modic改變危險(xiǎn)因素的條件Logistic回歸分析討論.4.小結(jié)經(jīng)過30余年的發(fā)展，MC由于其可引起LBP的特點(diǎn)日益得到重視，當(dāng)前已有不少學(xué)者針對其發(fā)生機(jī)制、危險(xiǎn)因素及防治方式方法進(jìn)行探究，但當(dāng)前MC的發(fā)病機(jī)制尚未完全明確，仍需進(jìn)一步研究，以更好地指導(dǎo)臨床防治。除此之外，當(dāng)前關(guān)于MC危險(xiǎn)因素的研究范圍仍較為局限，且部分因素對MC發(fā)生的影響仍存在爭議。故關(guān)于MC發(fā)生的危險(xiǎn)因素探究應(yīng)該進(jìn)一步深切進(jìn)入，努力減少、消除危險(xiǎn)因素，并進(jìn)而減少因MC發(fā)生而遭受LBP困擾的情況。以下為參考文獻(xiàn)[1]MODICMT,MASARYKTJ,ROSSJS,CARTERJR.Imagingofdegenerativediskdisease[J].Radiology,1988,168(1):177-186.[2]MODICMT,STEINBERGPM,ROSSJs,MASARYKTJ,CARTERJR.Degenerativediskdisease:assmnentofchangesinvertebralbodymarowwthMRimaging[J].Radiology,1988,166(1):193-199.[3]PETERSONCK,GATTERMANB,CARTERJC,HUMPHREYSBK,WEIBELA.Inter-andIntraexaninerReliabiityinIdentifyingandClassifyingDegenerativeMarrow(Modic)ChangesonLumbarSpineMagneticResonanceScans[J].JourmalofManipulativeandPhysiologicalTherapeutics,2007,30(2):85-90.[4]DUDLIs,HASCHTMANND,FERGUSONsJ.Persistentdegenerativechangesintheintervertebraldiscafterburstfractureinaninvitromodelmmickingphysiologicalpost-traumaticconditions[J].EurSpineJ,2021,24(9):1901-1908.[5]GEORGYM,STERNM,MURPHYK.WhatIstheRoleoftheBacteriumPropionibacteriumacnesinType1ModicChanges?AReviewoftheLiterature[].CanAssocRadiolJ,2021,68(4):419-424.[6]ALBERTHB,LAMBERTP,ROLLASONJ,SORENSENJS,WORTHINGTONT,PEDERSENMB,NORGAARDHs,VERNALLISA,BUSCHF,MANNICHEC,ELLIOTTTDoesnucleartissueinfectedwithbacteriafollowingdischermiationsleadtoModicchangesintheadjacentvertebrae?[J].EurSpineJ,2020,22(4):690-696.[7]WANGF,JIANGJM,DENGCH,WANGFL,FUZZ,ZHANGZF.ExpressionofFasreceptorandapoptosisinvertebralendplateswithdegenerativediscduseasescategorizedasModictypeIorII[J].Injury,2018,42(8):790-795.[8]GEISSALARSSONK,JUNEVIKK,RYDEVIKB,OLMARKERK.AutologousnucleuspulposusprimesTcellstodevelopintointerleukin-4-produaingeffectorcells:anexperimentalstudyontheautoimunepropertiesofnucleuspulposus[J].JOthopRes,2018,27(1):97-103.[9]RAJASEKARANS,KANNARM,REDDYRRNATESANS,RAVEENDRANM,CHEUNGKMC,CHAND,KAOPYP,YEEASHETTYAP.HowReliableAretheReportedGeneticAssociationsinDiscDegeneration?:TheInfluenceofPhenotypes,Age,PopulationSize,andInclusionSequencein809Patients[J].Spine(PhilaPa1976),2021,41(21):1649-1660.[10]KLAWITTERM,HAKOZAKIM,KOBAYASHIH,KRUPKOVAO,QUEROL,OSPELTC,GAYs,HAUSMANNO,LIEBSCHERT,MEIERU,SEKIGUCHIM,KONNOSs,BOOSN,FERGUSONSJ,WUERTZK.Expressionandregulationoftoll-likereceptors(TLRs)inhumanintervertebraldisccells[J]EurSpineJ,2020,23(9):1878-1891.[11]ZHAOF,POLLINTINEP,HOLEBD,DOLANP,ADAMSMA.DiscogenicOniginsofSpinalInstabilty[J].Spine,2005,30(23):2621-2630.[12]KUISMAM,KARPPINENJ,HAAPEAM,NINIM?KIJ,OJALARHELI?VAARAM,KORPELAINENRKAIKKONENK,TAIMELAS,NATRIA.Arethedeterminantsofvertebralendplatechangesandsevereduscdegenerationinthelumbarspinethesame?Amagneticresonanceimagingstudlyinmiddle-agedmaleworkers[J].BmcMusculoskeletalDisorders,2008,9(1):51.[13]MOKFP,SAMARTZISD,KARPPINENJ,FONGDY,LUKKD,CHEUNGKM.