Compound-C108-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECompoundC108Cat.No.:HY-131649CASNo.:15533-09-2分?式:C??H??N?O?分?量:270.28作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:25mg/mL(92.50mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.6999mL18.4993mL36.9987mL5mM0.7400mL3.6999mL7.3997mL10mM0.3700mL1.8499mL3.6999mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性CompoundC108?種G3BP2抑制劑。CompoundC108也靶向應(yīng)激顆粒相關(guān)蛋?、GTPase激活蛋?(SH3結(jié)構(gòu)域)結(jié)合蛋?2。CompoundC108顯著抑制?管鱗狀細(xì)胞癌(ESCC)細(xì)胞轉(zhuǎn)移。IC50&TargetG3BP2[1]體外研究CompoundC108(1μM;24h)showsanti-tumoractivityagainstBT474cells[1].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECompoundC108(4μM;24h)significantlydecreasestheproteinexpressionofG3BP2inG3BP2overexpressingKYSE410cellsandLINC01554transfectedKYSE30cells[2].CompoundC108(4μM;24h)attenuatesESCCcellmetastasis,migrationandinvasioninKYSE410,KYSE30andKYSE150cells[2].WesternBlotAnalysis[2]CellLine:G3BP2-overexpressingKYSE410cells,LINC01554-transfectedKYSE30cellsConcentration:4μMIncubationTime:24hResult:DecreasedtheproteinlevelofG3BP2andHDGF.體內(nèi)研究CompoundC108(1μM;24h)targetsanddecreasestumorinitiatingcells(TICs),whileinjectedBT-474cellstreatedwithCompoundC108intothemammaryfatpadoffemalenonobesediabetic/severecombinedimmunedeficiency(NOD-SCID)miceinalimiting-dilutionxenograftassay[1].REFERENCES[1].GuptaN,etal.Stressgranule-associatedproteinG3BP2regulatesbreasttumorinitiation.ProcNatlAcadSciUSA.2017Jan31;114(5):1033-1038.[2].ZhengY,etal.G3BP2regulatedbythelncRNALINC01554facilitatesesophagealsquamouscellcarcinomametastasisthroughstabilizingHDGFtranscript.Oncogene.2022Jan;41(4):515-526.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te