唐洲平 干細胞移植治療腦出血的Meta分析

胡洋唐洲平同濟醫(yī)院神經(jīng)內(nèi)科干細胞移植治療腦出血的Meta分析IntracerebralHemorrhageIncidence:24.6per100,000person-yearsoverall51.8per100,000person-yearsinAsianpeoplecasefatality:40.4%at1monthindependencyrate:between12%and39%高致殘率高致死率CharlotteJJvanAsch,LancetNeurol2010;9:167–76IntracerebralHemorrhageRichardFKeep,LancetNeurol2012;11:720–31StemCellTransplantationinICHFirstin1998B.Huang,/JournalofControlledRelease2012;464–473Metaanalysis19982012StemCellTransplantationinICHMarcosFCordeiro,WorldJStemCells2015,7(3):618-629細胞模型移植方法功能學結(jié)局組織學結(jié)局rADSCs膠原酶構(gòu)建大鼠腦出血模型造模成功48h后，2-4*10^7/10ul的脂肪干細胞注射到右側(cè)腦室移植后第3,7,14和28天后移植組比對照組大鼠的神經(jīng)功能缺損評分有明顯改善移植細胞能夠表達NeuN、NF及GFAP移植后VEGF因子表達顯著提升移植組宿主內(nèi)源性細胞凋亡比例顯著減少StemCellTransplantationinICHStemCellTransplantationinICHZeaLonga5-gradescaleTransplantationofBrdU-conjugatedADSCsDecreasedICH-inducedNeuralDysfunctionStemCellTransplantationinICHCBrdU-conjugatedADSCsDifferentiatedintoNeural-likeandGlia-likeCellsinvivoafterTransplantationTransplantationofBrdU-conjugatedADSCsupregulatedVEGFexpressionanddecreasedICH-inducedcellapoptosisStemCellTransplantationinICHMetaAnalysis-methodMetaAnalysis-methodFlowdiagramofpreferredreportingitemsforsystematicreviewsandmeta-analyses(PRISMA)MetaAnalysis-resultsMetaAnalysis-methodMetaAnalysis-resultsForestplotshowsmeaneffectsizeand95%CIformNSSMetaAnalysis-resultsForestplotshowsmeaneffectsizeand95%CIfortissuelossreductionForestplotshowsmeaneffectsizeand95%CIforMLPTMetaAnalysis-resultsForestplotshowsmeaneffectsizeand95%CIforrotarodtestMetaAnalysis-resultsPotentialMechanismsofTransplanted

Cell–MediatedRecoveryDifferentiateintoNeuronsorGlialcellsReleaseofTrophicFactors,Cytokines,andMicroRNAsPromoteAngiogenesisApoptosisPreventionAnti-inflammatoryEffectsStimulationandRecruitmentofEndogenousNSCAstrocyteandMicrogliaResponseModulationMarcosFCordeiro,WorldJStemCells2015,7(3):618-629NeuralStemCellPotentialMechanismsofTransplanted

Cell–MediatedRecoveryDifferentiateintoNeuronsorGlialcellsSang-WukJoeng,Stroke2003;34:2258-2263PotentialMechanismsofTransplanted

Cell–MediatedRecoveryDifferentiateintoNeuronsorGlialcellsMesenchymalStemCellHyun-SunLeeJournalofCellularBiochemistry116:310–319(2015)MesenchymalStemCellApoptosisPreventionPotentialMechanismsofTransplanted

Cell–MediatedRecoverySU-PINGWANG,MOLECULARMEDICINEREPORTS6:848-854,2012PotentialMechanismsofTransplanted

Cell–MediatedRecoveryApoptosisPreventionAdiposederivedStemCellTunel染色NeuralStemCellReleaseofTrophicFactors,Cytokines,andMicroRNAsELISAPotentialMechanismsofTransplanted

Cell–MediatedRecoveryTakumaWakai,ISCBFM2014;34,441–449iPSCPotentialMechanismsofTransplanted

Cell–MediatedRecoveryReleaseofTrophicFactors,Cytokines,andMicroRNAsJieQin,NeuroscienceLetters554(2013)70–75HematoxylinandeosinstainingPotentialMechanismsofTransplanted

Cell–MediatedRecoveryPromoteAngiogenesisMesenchymalStemCellMingFeng,THEJOURNALOFNUCLEARMEDICINE2011;52,1SystematicIdentific