基于logisic回歸分析的脾胃病辨治模型

基于logisic回歸分析的脾胃病辨治模型

1數(shù)據(jù)和方法詳細(xì)分析——腸疾病的風(fēng)險(xiǎn)飲食。2結(jié)果2.1綜合腎衰竭分析2.1.1腎不納氣虛菌體不固腎精不足2.Logit(p)=-3.7927+5.7487腎陰虛(0.676032)+6.2401腎虛(0.667176)+5.9199腎陽虛(0.423114)+5.3850腎氣虛(0.258826)+6.2075腎不納氣(0.246378)+5.5249腎氣不固(0.233715)+4.9910腎虛水泛(0.137236)+4.5861腎精不足(0.162370)+3.3418命門火衰(0.097448)+3.3899水氣凌心(0.059779)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>54.7,P=0.0001。Concordant=84.9%。2.1.2每一自變量w執(zhí)行Logit(p)=-1.7474-1.2199外風(fēng)(-0.165926)+1.5760房勞過度(0.071475)-1.5012外暑(-0.147354)-1.9512食積(-0.148594)+0.8358水(0.055855)-0.9057瘀血(-0.088907)+0.7408素體虛弱(0.053556)+0.7485勞神過度(0.046668)-0.8997外熱(-0.088023)-0.5495外寒(-0.063350)-1.3919伏邪(-0.078091)+0.5862內(nèi)燥(0.032681)-1.2836六淫(-0.065320)-0.6622飲食不節(jié)(-0.050545)-0.2254痰(-0.040661)-1.2930瘧邪(-0.060696)-0.5853惱怒(-0.047146)-2.6273癘氣(-0.094504)-0.9657飲食過涼(-0.051483)-0.1821內(nèi)濕(-0.034398)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>6.8,P<0.01。Concordant=45.2%。2.1.3每一自變量0.717.5Logit(p)=-2.1664+2.0680遺精(0.154637)+1.2941腰膝酸軟(0.105780)+1.0214腰痛(0.103489)-0.9095發(fā)熱(-0.161294)+0.5278脈細(xì)(0.112369)+0.8021氣喘(0.097198)+1.8571滑精(0.066799)+1.0374尿濁(0.070241)+0.7191脈虛(0.078867)-0.6573腹痛(-0.101661)+0.9369尿頻(0.058220)-0.7455脘痞(-0.097596)-1.0453胃脘痛(-0.111454)+0.7825耳鳴(0.057064)-0.4643黃苔(-0.078011)+1.1771足痿不用(0.049607)+1.4847遺尿(0.043975)-0.5977嘔吐(-0.087535)+1.2079脈少神(0.039677)+0.7002咳血(0.046308)-1.0864往來寒熱(-0.089575)+0.4085失眠(0.057276)-0.4454胸悶(-0.067948)+0.5358下肢浮腫(0.046542)+0.3827脈弱(0.045445)+1.3627婚后不孕(0.035761)+1.2055尿失禁(0.035704)-1.2861壯熱(-0.085826)+1.1041剝脫苔(0.036265)-0.3017脈滑(-0.056984)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>15.5,P=0.0001。Concordant=69.6%。2.1.4每一自變量的計(jì)算Logit(p)=-2.7630+1.0529熟地黃(0.175688)+0.9239山藥(0.138760)+1.3855菟絲子(0.106223)+0.8424生地黃(0.160135)+1.3953補(bǔ)骨脂(0.097533)+0.8187五味子(0.108024)+1.2323沙苑子(0.079518)+0.7058附子(0.098955)+0.9795女貞子(0.079990)-0.7878黃芩(-0.140171)+0.6027黃柏(0.085597)+1.0107肉蓯蓉(0.075928)+0.9338磁石(0.064478)-1.4543連翹(-0.187777)-0.4033當(dāng)歸(-0.094642)-1.0151厚樸(-0.152882)+0.4315茯苓(0.112308)+0.5365茯神(0.080775)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>50.1,P=0.0001。Concordant=80.4%。2.2腎綜合征的辨證分型2.2.1模型評(píng)價(jià)病因或病理結(jié)果:Logit(p)=-3.0883+1.3423內(nèi)燥(0.074831)+0.7420內(nèi)熱(火)(0.179376)+1.2907素體陰虛(0.062036)-1.6188外風(fēng)(-0.220179)-0.7069內(nèi)濕(-0.133499)+1.2693房勞過度(0.057564)-2.3803內(nèi)寒(-0.237450)+0.9040勞神過度(0.056362)-0.5340痰(-0.096337)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>16.8,P=0.0001。Concordant=49.6%。癥狀:Logit(p)=-3.2047+1.9923遺精(0.148973)+0.8718失眠(0.122239)+1.2710耳鳴(0.092682)+1.4889咯血(0.070732)+1.0336咳血(0.068364)-1.8109腹痛(-0.280085)+1.0308尿頻(0.064053)+1.1051五心煩熱(0.057101)-1.2153嘔吐(-0.177999)-0.8260胸悶(-0.126007)+1.4065脈少神(0.046198)+0.5728脈虛(0.062822)-0.7787發(fā)熱(-0.138102)+0.4095脈數(shù)(0.093833)+1.3062滑精(0.046982)-0.9415腹脹(-0.135965)+0.5372體瘦(0.062384)+0.7473尿濁(0.050602)-0.4836脈滑(-0.091344)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>17.8,P=0.0001。Concordant=69.4%。用藥:Logit(p)=-3.8870+1.1351熟地黃(0.189406)+1.1840生地黃(0.225066)+1.1232山藥(0.168695)+1.1033女貞子(0.090099)-0.7238白術(shù)(-0.161549)+0.7109五味子(0.093799)+0.7504黃柏(0.106569)+0.8648柏子仁(0.069304)+0.7006龜板(0.060331)-0.7100橘皮(-0.162470)+0.9578沙苑子(0.061805)+0.6707遠(yuǎn)志(0.080590)+0.6337北沙參(0.074786)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>31.8,P=0.0001。Concordant=80.4%。2.2.2模型評(píng)價(jià)及結(jié)果病因或病理結(jié)果:Logit(p)=-3.0233-1.2241外風(fēng)(-0.166489)+1.2888房勞過度(0.058448)-0.4169內(nèi)熱(火)(-0.100796)-2.0390外暑(-0.200147)-2.8636食積(-0.218078)+0.7408素體虛弱(0.053557)-0.8883瘀血(-0.087194)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>8.1,P<0.01。Concordant=34.9%。癥狀:Logit(p)=-3.5473+1.4331腰膝酸軟(0.117141)+1.1737腰痛(0.118921)+1.3096遺精(0.097927)+0.6787脈細(xì)(0.144490)-0.8449發(fā)熱(-0.149829)+0.7976痰多(0.070101)+1.5583遺尿(0.046153)+1.6072尿失禁(0.047601)+0.9720尿濁(0.065817)+1.1778失音(0.061758)+1.5586婚后不孕(0.040904)-0.4573脈數(shù)(-0.104785)+0.6128氣喘(0.074255)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>20.0,P=0.0001。Concordant=60.1%。用藥:Logit(p)=-4.0135+0.9689熟地黃(0.161682)+1.0309菟絲子(0.079033)+0.9792山藥(0.147071)+0.9477杜仲(0.097714)+1.0880補(bǔ)骨脂(0.076053)+0.9555肉蓯蓉(0.071780)+0.8939續(xù)斷(0.076983)+1.6187黑大豆(0.053828)+0.4760白術(shù)(0.106227)+0.5112麥冬(0.088356)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>26.9,P=0.0001。Concordant=71.3%。2.2.3nd最佳劑量wol2病因或病理結(jié)果:Logit(p)=-4.0487+1.4920內(nèi)寒(0.148836)+1.5545水(0.103889)-1.5265內(nèi)熱(火)(-0.369034)+1.1156飲(0.108281)+1.3112房勞過度(0.059463)-1.2608外風(fēng)(-0.171491)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>10.7,P<0.01。Concordant=50.6%。癥狀:Logit(p)=-4.3406+0.9019淡白舌(0.087358)+1.3869畏寒(0.133518)+0.7890脈沉(0.127823)+0.8758泄瀉(0.145179)+1.4284尿頻(0.088756)-1.3973脈數(shù)(-0.320166)+1.0635下肢浮腫(0.092373)+1.1456遍身浮腫(0.084351)+1.4287消化不良(0.067066)-1.4181發(fā)熱(-0.251490)+1.0065腰膝酸軟(0.082270)-1.1330脈滑(-0.214005)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>19.8,P=0.0001。Concordant=69.8%。用藥:Logit(p)=-5.2923+2.4880附子(0.348847)+1.7837菟絲子(0.136749)+1.1612補(bǔ)骨脂(0.081170)+0.7593茯苓(0.197597)+1.2495五味子(0.164872)+0.7048澤瀉(0.112238)-1.3998麥冬(-0.241923)-1.6411柴胡(-0.251672)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>15.2,P=0.0001。Concordant=83.4%。2.2.4單次給藥量0.713病因或病理結(jié)果:Logit(p)=-4.7755+2.0723房勞過度(0.093982)+1.4763素體虛弱(0.106726)-1.0943內(nèi)熱(火)(-0.264553)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>19.1,P=0.0001。Concordant=32.1%。癥狀:Logit(p)=-5.4178+1.1695精神不振(0.139462)+1.5909遺精(0.118961)+1.2950尿頻(0.080468)+1.2484氣喘(0.151269)+1.3948癃閉(0.085628)+1.5599咳血(0.103175)+1.8536尿失禁(0.054900)+1.2153小便不利(0.110808)+1.0327脈虛(0.113261)+1.9975強(qiáng)硬舌(0.066826)-1.5499發(fā)熱(-0.274859)+0.6411脈弱(0.076118)-0.8371脈數(shù)(-0.191818)+0.5521脈細(xì)(0.117541)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>7.0,P<0.01。Concordant=69.7%。用藥:Logit(p)=-5.8608+1.4715山藥(0.221001)+1.4897菟絲子(0.114211)+0.9593附子(0.134502)+2.5079白果(0.065815)+1.2963益智仁(0.092059)+2.2356生姜皮(0.100724)+0.9174人參(0.180547)+1.7690桑螵蛸(0.068396)+0.9564牛膝(0.146735)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>20.0,P=0.0001。Concordant=74.1%。2.2.5單次給藥量d病因或病理結(jié)果:Logit(p)=-5.1665-0.9132內(nèi)熱(火)(-0.220758)+0.9493痰(0.171266)2.4805吸煙過多(0.039761)+1.1237素體虛弱(0.081237)+1.3176失血過多(0.057983)-2.1574外風(fēng)(-0.293442)-0.9393內(nèi)濕(-0.177379)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>4.6,P<0.05。Concordant=43.0%。癥狀:Logit(p)=-6.0742+2.6451氣喘(0.320514)+1.9248氣短(0.165324)+2.0011冷汗(0.067746)+1.5668出血(0.076810)+2.3231肛門下墜(0.083558)-2.1595黃苔(-0.362840)+1.1432呼吸急促(0.089651)+1.4289哮鳴(0.055495)-1.8239發(fā)熱(-0.323439)-1.7034胸悶(-0.259847)+0.6869咳嗽(0.133608)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>8.8,P<0.01。Concordant=80.7%。用藥:Logit(p)=-6.4723+2.2163核桃仁(0.103723)+1.2920山茱萸(0.149632)+2.0020紫石英(0.116719)+1.9942海浮石(0.115580)+1.1202五味子(0.147817)+1.6316磁石(0.112668)+1.1618山藥(0.174494)+1.3794沉香(0.119710)+0.8604牛膝(0.132010)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>12.3,P<0.001。Concordant=78.8%。2.2.6每一自變量w保證2、3.4病因或病理結(jié)果:Logit(p)=-5.0461+3.5024說話過多(0.046445)+1.5910勞神過度(0.099200)+1.2939素體虛弱(0.093537)-0.8040內(nèi)熱(火)(-0.194370)+1.4281素體陰虛(0.068639)+1.5971驚嚇(0.068564)-1.1900痰(-0.214702)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>6.6,P<0.01。Concordant=40.3%。癥狀:Logit(p)=-5.9492+3.4165遺精(0.255468)+3.2404遺尿(0.095974)+2.7877尿清長(zhǎng)(0.088669)+1.4028腰膝酸軟(0.114665)+.4982尿失禁(0.073990)+1.6841尿頻(0.104645)+1.7371滑精(0.062482)+1.1370氣喘(0.137775)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>13.7,P<0.001。Concordant=69.3%。用藥:Logit(p)=-6.1808+1.5404金櫻子(0.061398)+2.2698桑螵蛸(0.087762)+1.8246菟絲子(0.139886)+1.4602蓮子(0.109441)+1.2591黃柏(0.178823)+1.1699龍骨(0.086457)+0.9229五味子(0.121779)+1.8585蓮須(0.064013)+1.4953覆盆子(0.052656)+1.5064海螵蛸(烏賊骨)(0.083259)+0.7765人參(0.152821)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>11.8,P<0.001。Concordant=78.2%。2.2.7每一自變量w控制病因或病理結(jié)果:Logit(p)=-6.1381+3.5003水(0.233930)-2.7222內(nèi)熱(火)(-0.658105)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>7.2,P<0.01。Concordant=51.9%。癥狀:Logit(p)=-6.8654+2.4313遍身浮腫(0.179027)+1.6084下肢浮腫(0.139707)+1.3478淡白舌(0.130553)+1.3803氣喘(0.167259)+1.5707滑苔(0.091217)+0.9488脈沉(0.153724)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>9.1,P<0.01。Concordant=68.2%。用藥:Logit(p)=-7.9803+2.0294附子(0.284538)+1.2720澤瀉(0.202558)+2.0485桑白皮(0.191585)+1.9718細(xì)辛(0.138932)+1.9310核桃仁(0.090371)+1.4438茯苓(0.375755)+3.0255甘遂(0.080938)+1.7055西洋參(0.148768)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>8.1,P<0.01。Concordant=76.1%。2.2.8cordan案病因或病理結(jié)果:Logit(p)=-5.6874+3.3823說話過多(0.044852)+2.3098房勞過度(0.104752)+1.6811素體虛弱(0.121530)+1.5713勞神過度(0.097971)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>13.2,P<0.001。Concordant=22.1%。癥狀:Logit(p)=-5.9780+2.1303遺精(0.159295)+2.3313足痿不用(0.098251)+2.3456語音低微(0.089050)+2.4520強(qiáng)硬舌(0.082032)+2.7649脈促(0.085574)+1.5448小便不利(0.140853)+1.4378腰痛(0.145683)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>18.8,P=0.0001。Concordant=45.0%。用藥:Logit(p)=-6.1797+1.8552肉蓯蓉(0.139370)+1.7790芡實(shí)(0.114439)+1.8689核桃仁(0.087462)+1.9461鹿茸(0.082324)+1.1268熟地黃(0.188027)+1.8862覆盆子(0.066424)+1.4417沙苑子(0.093036)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>15.2,P=0.0001。Concordant=59.5%。2.2.9每一自變量a型病因或病理結(jié)果:Logit(p)=-5.7376+1.1207內(nèi)寒(0.111794)-1.3451內(nèi)熱(火)(-0.325175)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>7.7,P<0.01。Concordant=30.2%。癥狀:Logit(p)=-6.4573+2.2115尿清長(zhǎng)(0.070342)+2.2028完谷不化(0.076728)+2.1492尿頻(0.133550)+3.0502脈少神(0.100189)1.2017脈微(0.087952)+1.0481脈無力(0.109647)+2.5329口腔糜爛(0.071482)+0.9343手足俱冷(0.096956)+2.1223白痢(0.078293)+1.0240體瘦(0.118910)-1.3617脈弦(-0.324781)+1.4714背痛(0.091743)+0.7889脈沉(0.127813)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>5.7,P<0.02。Concordant=58.4%。用藥:Logit(p)=-7.2269+2.4310附子(0.340861)+2.4688益智仁(0.175320)+2.4691肉豆蔻(0.100060)+1.7798山藥(0.267310)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>32.1,P=0.0001。Concordant=77.0%。2.2.1模型評(píng)價(jià)及藥代動(dòng)力學(xué)參數(shù)病因或病理結(jié)果:Logit(p)=-7.4788+3.1771水(0.212329)+2.0293飲(0.196953)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>17.3,P=0.0001。Concordant=51.1%。癥狀:Logit(p)=-8.2247+3.4749心悸(0.384638)+3.5892肌膚發(fā)涼(0.148965)+2.8763脈緊(0.222695)+4.1816口瘡(0.117009)+2.2707遍身浮腫(0.167199)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>12.6,P<0.001。Concordant=78.8%。用藥:Logit(p)=-7.6967+3.5016決明子(0.115016)+3.1444葫蘆巴(0.089486)+3.3681西瓜翠衣(0.102025)+1.7497桂枝(0.279650)+1.9742酸棗仁(0.237132)+2.8098草豆蔻(0.088176)。模型評(píng)價(jià):對(duì)于每一自變量都有Waldχ2>7.2,P<0.01。Concordant=58.5%。3腎的生理功能上述結(jié)果的統(tǒng)計(jì)意義的詳細(xì)說明,見“臟腑病辨證用藥的Logistic回歸分析—脾(胃)病篇”。根據(jù)上述統(tǒng)計(jì)結(jié)果,選取標(biāo)準(zhǔn)化回歸系數(shù)較大的自變量進(jìn)行分析,初步發(fā)現(xiàn)腎的發(fā)病規(guī)律如下。多見虛證,不見實(shí)證:①房勞過度、勞神過度、素體虛弱是導(dǎo)致腎病的主要原因,而六