腓骨蛋白說(shuō)明

IntegratingCellsIntoIntegratingCellsIntocell-cellandcellmatrixadhesion：anoverviewcell-cellandcell-ECMjunctionsandtheiradhesionmoleculesTheExtracellularMatrixI:TheBasalTheExtracellularMatrixII:ConnectiveAdhesiveInteractionsinMotileandNonmotileCellsPlans20.320.3TheExtracellularMatrixI:TheBasalLamina細(xì)胞外基質(zhì)：基(底)板/TheBasalTheBasalLaminaProvidesaFoundationforAssemblyofCellsintoTissuesBasallamina基(底)aFigureaFigure層粘蛋層粘蛋基底膜聚糖(串珠素fig20-fig20-TypeIVlinkedtolinkedtoanchoredtotheadjacentconnectivetissuebasementLaminin,aLaminin,aMulti-adheesiveMatrixProtein,HelpsCross-linkComponentsoftheBasalLamina（16Figfig20-α,and?fig20-α,and?5α,3β,and3?chainsdevelopmental-stage-N-bindtooneanothermeshlikenetworks.bindingto Sheet-formingTypeIV Sheet-formingTypeIVCollagenIsaMajorStructuralComponentoftheBasalFigure(inorange)fig20-24andfig20-24andtabe20-atleast28tripleGly-X-StructureandassemblyoftypeStructureandassemblyoftypeIVSide-sideC-ternimalglobular–headdomainHead-headandtail-HigherorderFigurePerlecan,aProteoglycan,Cross-linksComponentsofPerlecan,aProteoglycan,Cross-linksComponentsoftheBasalLaminaandCell-Surface(LG&Ig)(O-LinkedKEYKEYCONCEPTSofSectionExtracellularExtracellularMatrixII:ConnectiveTissue膠原蛋Glycosaminoglycans膠原蛋Glycosaminoglycans（GAG）糖胺聚Proteoglycans蛋白聚Multi-adhesiveproteins多粘蛋Elastin彈性蛋FibrillarCollagensAretheMajorFibrousProteinsintheFibrillarCollagensAretheMajorFibrousProteinsintheECMofConnectiveTissuesFibrillarCollagenIsSecretedandAssambledintoFibrillarCollagenIsSecretedandAssambledintoFibrilsOutsidetheCellintypeintypetypeFibrilsoftypeintendonsFibrilsoftypeII(In(In扭(In(In扭linktoFigureProteoglycansandTheirProteoglycansandTheirConstituentGAGsPlayDiverseRolesintheECM①②③④Fig肝透Fig肝透明質(zhì)硫酸角質(zhì)硫酸軟骨(或真皮)E.g.(GAG-sequencelinkedE.g.(GAG-sequencelinkedinthereadpositionsbindtoandactivateATIIIessentialforthisheparinfunction。(O-)linkedFigure20.30PentasaccharideGAGsequencethatregulatestheactivityofanti-thrombinIII(ATIII).HyaluronanResistsCompression,FacilitatesCellMigration,andGivesHyaluronanResistsCompression,FacilitatesCellMigration,andGivesCartilageItsGel-likePropertiesFibronectinsFibronectinsInterconnectCellsandMatrix,InfiuencingCellShape,Differentiation,andMovementintegrinintegrinE.gFigElasticFibersPermitManyElasticFibersPermitManyTissuestoUndergoRepeatedStretchingandRecoilingelastin彈蛋FigFigMetalloproteasesRemodelandDegradeMetalloproteasesRemodelandDegrade3MMPs基質(zhì)金屬去整合素金屬蛋白帶凝血酶敏感酶序的TIMPs金屬蛋白酶組織抑制因子KEYKEYCONCEPTSofSection20.5A