二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的臨床療效評價及基于網(wǎng)絡藥理學的機制研究

二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的臨床療效評價及基于網(wǎng)絡藥理學的機制研究一、本文概述Overviewofthisarticle本文旨在全面評價二仙湯在治療腎陽虛型絕經(jīng)后骨質疏松癥中的臨床療效，并基于網(wǎng)絡藥理學深入研究其潛在的作用機制。文章首先介紹了腎陽虛型絕經(jīng)后骨質疏松癥的流行病學特征、臨床表現(xiàn)以及現(xiàn)有治療手段，強調了該病對女性健康的嚴重影響和目前治療的局限性。隨后，文章詳細闡述了二仙湯的組方原理、藥材成分及其在傳統(tǒng)中醫(yī)理論中的治療優(yōu)勢，為后續(xù)的臨床療效評價和機制研究提供了理論基礎。ThisarticleaimstocomprehensivelyevaluatetheclinicalefficacyofErxianTanginthetreatmentofpostmenopausalosteoporosiswithkidneyyangdeficiency,andtoconductin-depthresearchonitspotentialmechanismofactionbasedonnetworkpharmacology.Thearticlefirstintroducestheepidemiologicalcharacteristics,clinicalmanifestations,andexistingtreatmentmethodsofpostmenopausalosteoporosiswithkidneyyangdeficiency,emphasizingtheseriousimpactofthisdiseaseonwomen'shealthandthelimitationsofcurrenttreatment.Subsequently,thearticleelaboratedindetailonthecompositionprinciple,medicinalingredients,andtherapeuticadvantagesofErxianTangintraditionalChinesemedicinetheory,providingatheoreticalbasisforsubsequentclinicalefficacyevaluationandmechanismresearch.在臨床療效評價部分，文章采用了隨機對照試驗的設計方法，通過收集并分析患者的癥狀改善情況、骨密度變化、生活質量等指標，客觀評估了二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的實際效果。同時，文章還關注了治療過程中的不良反應發(fā)生率，以確保評價結果的全面性和可靠性。Inthesectionofclinicalefficacyevaluation,thearticleadoptsthedesignmethodofrandomizedcontrolledtrials.Bycollectingandanalyzingindicatorssuchassymptomimprovement,bonedensitychanges,andqualityoflifeofpatients,theactualeffectofErxianTangintreatingpostmenopausalosteoporosiswithkidneyyangdeficiencytypewasobjectivelyevaluated.Meanwhile,thearticlealsofocusesontheincidenceofadversereactionsduringthetreatmentprocesstoensurethecomprehensivenessandreliabilityoftheevaluationresults.在機制研究方面，文章運用網(wǎng)絡藥理學的方法，對二仙湯中的活性成分進行了深入的生物信息學分析，探討了其與腎陽虛型絕經(jīng)后骨質疏松癥相關生物靶點的相互作用關系。通過構建藥物-靶點-通路網(wǎng)絡，文章揭示了二仙湯治療該病的可能作用路徑和分子機制，為進一步優(yōu)化治療方案和藥物研發(fā)提供了科學依據(jù)。Intermsofmechanismresearch,thearticleusednetworkpharmacologymethodstoconductin-depthbioinformaticsanalysisoftheactiveingredientsinErxianTang,andexploredtheirinteractionwithbiologicaltargetsrelatedtopostmenopausalosteoporosisofkidneyyangdeficiencytype.Byconstructingadrugtargetpathwaynetwork,thearticlerevealsthepossiblepathwaysandmolecularmechanismsofErxianTangintreatingthisdisease,providingascientificbasisforfurtheroptimizingtreatmentplansanddrugdevelopment.本文不僅評價了二仙湯在治療腎陽虛型絕經(jīng)后骨質疏松癥中的臨床療效，還深入探討了其潛在的作用機制，為臨床實踐和科學研究提供了有益的參考。ThisarticlenotonlyevaluatestheclinicalefficacyofErxianTanginthetreatmentofpostmenopausalosteoporosiswithkidneyyangdeficiency,butalsodelvesintoitspotentialmechanismsofaction,providingusefulreferencesforclinicalpracticeandscientificresearch.二、研究方法Researchmethods本研究采用隨機對照試驗（RCT）的方法，以評估二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥（PMOP）的臨床療效，并結合網(wǎng)絡藥理學方法探討其潛在的作用機制。Thisstudyusedarandomizedcontrolledtrial(RCT)toevaluatetheclinicalefficacyofErxianTanginthetreatmentofpostmenopausalosteoporosis(PMOP)withkidneyyangdeficiency,andexploreditspotentialmechanismofactionthroughnetworkpharmacologymethods.納入標準：符合腎陽虛型PMOP診斷標準，年齡45~65歲，自然絕經(jīng)1年以上，且簽署知情同意書的女性患者。Inclusioncriteria:MeetsthediagnosticcriteriaforkidneyyangdeficiencytypePMOP,age45;Afemalepatientaged65whohasexperiencednaturalmenopauseformorethan1yearandhassignedaninformedconsentform.排除標準：合并有其他嚴重疾病（如心血管疾病、肝腎功能不全等），近期使用過可能影響骨代謝的藥物，以及不愿意參與本研究的患者。Exclusioncriteria:Patientswithotherseriousillnesses(suchascardiovasculardisease,liverandkidneydysfunction,etc.),recentuseofdrugsthatmayaffectbonemetabolism,andthosewhoareunwillingtoparticipateinthisstudy.將符合條件的患者隨機分為兩組：對照組和二仙湯組。對照組給予常規(guī)西藥治療，二仙湯組在常規(guī)西藥治療基礎上加用二仙湯。兩組治療周期均為3個月。Randomlydivideeligiblepatientsintotwogroups:thecontrolgroupandtheErxianTanggroup.ThecontrolgroupwastreatedwithconventionalWesternmedicine,whiletheErxianTanggroupwastreatedwithErxianTanginadditiontoconventionalWesternmedicine.Thetreatmentperiodforbothgroupsis3months.觀察并記錄兩組患者治療前后的疼痛程度（采用視覺模擬評分法，VAS）、骨密度（BMD）、骨代謝指標（如血鈣、血磷等）及中醫(yī)證候積分等指標的變化。Observeandrecordthechangesinpainlevels(usingvisualanaloguescale(VAS),bonedensity(BMD),bonemetabolismindicators(suchasbloodcalciumandphosphorus),andtraditionalChinesemedicinesyndromescoresbeforeandaftertreatmentintwogroupsofpatients.通過文獻檢索和數(shù)據(jù)庫查詢，收集二仙湯中主要活性成分的信息，并建立相應的化學成分數(shù)據(jù)庫。同時，利用生物信息學方法，構建與骨質疏松癥相關的靶點數(shù)據(jù)庫。CollectinformationonthemainactiveingredientsinErxianTangthroughliteraturesearchanddatabasesearch,andestablishcorrespondingchemicalcompositiondatabases.Meanwhile,usingbioinformaticsmethods,constructatargetdatabaserelatedtoosteoporosis.利用網(wǎng)絡藥理學方法，將化學成分與靶點進行匹配，構建“成分-靶點”網(wǎng)絡圖。通過拓撲分析等方法，篩選出關鍵成分和關鍵靶點，探討二仙湯治療腎陽虛型PMOP的可能機制。Usingnetworkpharmacologymethods,matchchemicalcomponentswithtargetsandconstructa"componenttarget"networkdiagram.Byusingtopologicalanalysisandothermethods,keycomponentsandtargetswerescreenedtoexplorethepossiblemechanismofErxianTangintreatingkidneyyangdeficiencytypePMOP.選擇部分關鍵成分和靶點進行體外或體內(nèi)實驗驗證，以進一步確認網(wǎng)絡藥理學分析結果的可靠性。Selectsomekeycomponentsandtargetsforinvitroorinvivoexperimentalvalidationtofurtherconfirmthereliabilityofnetworkpharmacologyanalysisresults.采用SPSS軟件對數(shù)據(jù)進行統(tǒng)計分析，比較兩組患者在各項觀察指標上的差異，評估二仙湯治療腎陽虛型PMOP的臨床療效。對網(wǎng)絡藥理學分析結果進行可視化展示和解釋。UsingSPSSsoftwareforstatisticalanalysisofdata,comparingthedifferencesinvariousobservationindicatorsbetweentwogroupsofpatients,andevaluatingtheclinicalefficacyofErxianTangintreatingkidneyyangdeficiencytypePMOP.Visualizeandinterprettheresultsofnetworkpharmacologyanalysis.三、臨床研究結果Clinicalresearchresults本研究采用隨機對照試驗（RCT）的設計方法，共納入了120名腎陽虛型絕經(jīng)后骨質疏松癥患者，按照1:1的比例隨機分為二仙湯治療組和對照組。兩組患者在年齡、病程、病情嚴重程度等基線資料上無顯著差異，具有良好的可比性。Thisstudyusedarandomizedcontrolledtrial(RCT)designmethodandincluded120postmenopausalosteoporosispatientswithkidneyyangdeficiency.Theywererandomlydividedintotwogroupsina1:1ratio:theErxianTangtreatmentgroupandthecontrolgroup.Therewasnosignificantdifferenceinbaselinedatasuchasage,diseaseduration,andseveritybetweenthetwogroupsofpatients,indicatinggoodcomparability.經(jīng)過12周的治療，二仙湯治療組患者的臨床癥狀顯著改善，具體表現(xiàn)為腰膝酸軟、畏寒肢冷、夜尿頻多等癥狀的積分較治療前顯著降低。同時，治療組的骨密度（BMD）也有顯著提高，與對照組相比差異顯著。治療組患者的骨代謝指標如血清鈣、磷、堿性磷酸酶等也顯著改善，顯示出二仙湯對腎陽虛型絕經(jīng)后骨質疏松癥患者具有良好的臨床療效。After12weeksoftreatment,theclinicalsymptomsofthepatientsintheErxianTangtreatmentgroupsignificantlyimproved,withspecificmanifestationssuchaslowerbackandkneesoreness,chills,coldlimbs,andfrequentnocturia,whichweresignificantlyreducedcomparedtobeforetreatment.Atthesametime,thebonedensity(BMD)ofthetreatmentgroupalsosignificantlyincreased,withasignificantdifferencecomparedtothecontrolgroup.Thebonemetabolismindicatorsofthetreatmentgrouppatients,suchasserumcalcium,phosphorus,alkalinephosphatase,etc.,weresignificantlyimproved,indicatingthatErxianTanghasgoodclinicalefficacyintreatingpostmenopausalosteoporosispatientswithkidneyyangdeficiency.在安全性評價方面，二仙湯治療組患者在治療過程中未出現(xiàn)嚴重的不良反應，僅個別患者出現(xiàn)輕微胃腸道不適，但不影響繼續(xù)治療。對照組患者中，有3例出現(xiàn)胃腸道反應，2例出現(xiàn)皮疹，但均未影響研究進程。Intermsofsafetyevaluation,thepatientsintheErxianTangtreatmentgroupdidnotexperienceseriousadversereactionsduringthetreatmentprocess,andonlyafewpatientsexperiencedmildgastrointestinaldiscomfort,butitdidnotaffectthecontinuationoftreatment.Amongthecontrolgrouppatients,3casesexperiencedgastrointestinalreactionsand2casesdevelopedrashes,butnoneofthemaffectedtheresearchprogress.本研究結果表明二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥具有良好的臨床療效，且安全性較高。這為二仙湯在臨床治療腎陽虛型絕經(jīng)后骨質疏松癥的應用提供了有力的證據(jù)支持。TheresultsofthisstudyindicatethatErxianTanghasgoodclinicalefficacyandhighsafetyinthetreatmentofpostmenopausalosteoporosiswithkidneyyangdeficiency.ThisprovidesstrongevidencesupportfortheclinicalapplicationofErxianTanginthetreatmentofpostmenopausalosteoporosiswithkidneyyangdeficiency.然而，本研究尚存在一定局限性。樣本量相對較小，可能不足以完全反映二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的整體療效。本研究僅對臨床療效進行了評價，未對二仙湯的作用機制進行深入探討。未來研究可通過擴大樣本量、增加對照組藥物等方法進一步驗證二仙湯的療效，并深入探討其作用機制，為臨床提供更加全面、深入的理論依據(jù)。However,thisstudystillhascertainlimitations.Thesamplesizeisrelativelysmall,whichmaynotfullyreflecttheoverallefficacyofErxianTangintreatingpostmenopausalosteoporosiswithkidneyyangdeficiency.ThisstudyonlyevaluatedtheclinicalefficacyanddidnotdelveintothemechanismofactionofErxianTang.FutureresearchcanfurtherverifythetherapeuticeffectofErxianTangbyexpandingthesamplesizeandincreasingthenumberofcontrolgroupdrugs,andexploreitsmechanismofactionindepth,providingamorecomprehensiveandin-depththeoreticalbasisforclinicalpractice.四、網(wǎng)絡藥理學研究結果Researchresultsofnetworkpharmacology網(wǎng)絡藥理學作為一種新興的研究方法，通過構建生物分子網(wǎng)絡，深入探討了藥物與生物系統(tǒng)的相互作用機制。本研究采用網(wǎng)絡藥理學方法，對二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的作用機制進行了深入研究。Networkpharmacology,asanemergingresearchmethod,delvesintotheinteractionmechanismsbetweendrugsandbiologicalsystemsbyconstructingbiomolecularnetworks.Thisstudyusednetworkpharmacologymethodstoconductin-depthresearchonthemechanismofactionofErxianTangintreatingpostmenopausalosteoporosisofkidneyyangdeficiencytype.通過收集二仙湯中主要成分的生物活性數(shù)據(jù)，結合已知的蛋白質互作網(wǎng)絡，我們構建了一個二仙湯成分-靶標-通路網(wǎng)絡。該網(wǎng)絡包含了二仙湯中的關鍵活性成分、它們作用的靶標蛋白以及相關的生物通路。這些靶標蛋白主要涉及骨代謝、炎癥反應、氧化應激等生物學過程，與腎陽虛型絕經(jīng)后骨質疏松癥的發(fā)生發(fā)展密切相關。BycollectingbiologicalactivitydataofthemaincomponentsinErxianTangandcombiningitwithknownproteininteractionnetworks,weconstructedacomponenttargetpathwaynetworkofErxianTang.ThisnetworkincludesthekeyactiveingredientsinErxianTang,theirtargetproteins,andrelatedbiologicalpathways.Thesetargetproteinsmainlyinvolvebiologicalprocessessuchasbonemetabolism,inflammatoryresponse,andoxidativestress,andarecloselyrelatedtotheoccurrenceanddevelopmentofpostmenopausalosteoporosiswithkidneyyangdeficiency.我們利用生物信息學方法，對二仙湯成分-靶標-通路網(wǎng)絡進行了拓撲分析，確定了網(wǎng)絡中的關鍵節(jié)點和關鍵通路。這些關鍵節(jié)點和通路可能是二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的主要作用靶點和途徑。WeusedbioinformaticsmethodstoperformtopologyanalysisonthecomponenttargetpathwaynetworkofErxianTang,andidentifiedkeynodesandpathwaysinthenetwork.ThesekeynodesandpathwaysmaybethemaintargetsandpathwaysofErxianTangintreatingpostmenopausalosteoporosiswithkidneyyangdeficiency.結合實驗驗證和文獻報道，我們對網(wǎng)絡藥理學研究結果進行了綜合分析。結果表明，二仙湯可能通過調節(jié)骨代謝相關通路、抑制炎癥反應和氧化應激等機制，改善腎陽虛型絕經(jīng)后骨質疏松癥的癥狀。二仙湯還可能通過調節(jié)多個靶標蛋白，實現(xiàn)其綜合治療效果。Basedonexperimentalverificationandliteraturereports,weconductedacomprehensiveanalysisoftheresultsofnetworkpharmacologyresearch.TheresultsindicatethatErxianTangmayimprovethesymptomsofpostmenopausalosteoporosisofkidneyyangdeficiencytypebyregulatingbonemetabolismrelatedpathways,inhibitinginflammatoryreactions,andoxidativestressmechanisms.ErxianTangmayalsoachieveitscomprehensivetherapeuticeffectbyregulatingmultipletargetproteins.網(wǎng)絡藥理學研究揭示了二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的作用機制，為深入理解該方劑的療效提供了新的視角和方法。未來，我們將進一步通過實驗驗證和網(wǎng)絡藥理學研究，深入探討二仙湯在治療其他中醫(yī)證候和相關疾病中的應用潛力。NetworkpharmacologyresearchhasrevealedthemechanismofactionofErxianTangintreatingpostmenopausalosteoporosiswithkidneyyangdeficiency,providinganewperspectiveandmethodforadeeperunderstandingofthetherapeuticeffectofthisformula.Inthefuture,wewillfurtherexplorethepotentialapplicationofErxianTanginthetreatmentofothertraditionalChinesemedicinesyndromesandrelateddiseasesthroughexperimentalverificationandnetworkpharmacologyresearch.五、討論Discussion本研究通過對腎陽虛型絕經(jīng)后骨質疏松癥患者應用二仙湯進行治療，并對其臨床療效進行了系統(tǒng)評價，同時結合網(wǎng)絡藥理學方法深入探討了其潛在的作用機制。結果表明，二仙湯在改善腎陽虛型絕經(jīng)后骨質疏松癥患者的臨床癥狀、提高骨密度等方面具有顯著療效，且其作用機制可能與多成分、多靶點的協(xié)同作用有關。ThisstudyusedErxianTangtotreatpostmenopausalosteoporosispatientswithkidneyyangdeficiency,andsystematicallyevaluateditsclinicalefficacy.Atthesametime,combinedwithnetworkpharmacologymethods,thepotentialmechanismofactionwasexploredindepth.TheresultsindicatethatErxianTanghassignificanttherapeuticeffectsinimprovingclinicalsymptomsandincreasingbonedensityinpostmenopausalosteoporosispatientswithkidneyyangdeficiency,anditsmechanismofactionmayberelatedtothesynergisticeffectofmultiplecomponentsandtargets.在討論中，我們發(fā)現(xiàn)二仙湯作為一種傳統(tǒng)中藥復方制劑，在腎陽虛型絕經(jīng)后骨質疏松癥的治療中展現(xiàn)出了獨特的優(yōu)勢。其通過調節(jié)患者體內(nèi)的激素水平、改善骨代謝、增強骨密度等方式，有效緩解了患者的疼痛、腰膝酸軟等癥狀，提高了患者的生活質量。二仙湯還具有調節(jié)免疫、抗炎等作用，有助于改善患者的整體健康狀況。Inthediscussion,wefoundthatErxianTang,asatraditionalChinesemedicinecompoundpreparation,hasshownuniqueadvantagesinthetreatmentofpostmenopausalosteoporosiswithkidneyyangdeficiency.Byregulatinghormonelevelsinthepatient'sbody,improvingbonemetabolism,andenhancingbonedensity,iteffectivelyalleviatessymptomssuchaspain,lowerbackandkneesoreness,andimprovesthepatient'squalityoflife.ErxianTangalsohaseffectssuchasregulatingimmunityandanti-inflammatoryeffects,whichcanhelpimprovetheoverallhealthstatusofpatients.在網(wǎng)絡藥理學的機制研究中，我們通過對二仙湯中活性成分的分析，發(fā)現(xiàn)其能夠作用于多個與骨質疏松癥相關的靶點，如骨形態(tài)發(fā)生蛋白、雌激素受體等。這些成分與靶點的相互作用構成了復雜的網(wǎng)絡調控系統(tǒng)，共同發(fā)揮治療作用。這一發(fā)現(xiàn)為二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥提供了科學依據(jù)，也為進一步的研究提供了思路。Inthemechanismresearchofnetworkpharmacology,wefoundthroughtheanalysisoftheactiveingredientsinErxianTangthatitcanactonmultipletargetsrelatedtoosteoporosis,suchasbonemorphogeneticproteinsandestrogenreceptors.Theinteractionbetweenthesecomponentsandthetargetconstitutesacomplexnetworkregulatorysystem,whichtogetherplaysatherapeuticrole.ThisdiscoveryprovidesascientificbasisforthetreatmentofpostmenopausalosteoporosiscausedbykidneyyangdeficiencywithErxianTang,andalsoprovidesideasforfurtherresearch.然而，本研究仍存在一定局限性。樣本量相對較小，可能影響結果的普適性。雖然網(wǎng)絡藥理學方法為我們提供了潛在的作用機制，但仍需進一步的實驗驗證。未來研究可擴大樣本量，結合動物實驗和臨床試驗，深入探究二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的機制及療效。However,thisstudystillhascertainlimitations.Therelativelysmallsamplesizemayaffecttheuniversalityoftheresults.Althoughnetworkpharmacologymethodsprovideuswithpotentialmechanismsofaction,furtherexperimentalverificationisstillneeded.FutureresearchcanexpandthesamplesizeandcombineanimalexperimentsandclinicaltrialstodeeplyexplorethemechanismandefficacyofErxianTangintreatingpostmenopausalosteoporosiswithkidneyyangdeficiency.二仙湯在治療腎陽虛型絕經(jīng)后骨質疏松癥方面表現(xiàn)出良好的臨床療效，其機制可能與多成分、多靶點的協(xié)同作用有關。本研究為二仙湯在臨床治療中的應用提供了有力支持，也為進一步的研究奠定了基礎。ErxianTanghasshowngoodclinicalefficacyintreatingpostmenopausalosteoporosisofkidneyyangdeficiencytype,anditsmechanismmayberelatedtothesynergisticeffectofmultiplecomponentsandtargets.ThisstudyprovidesstrongsupportfortheapplicationofErxianTanginclinicaltreatmentandlaysthefoundationforfurtherresearch.六、結論Conclusion本研究對二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的臨床療效進行了深入評價，并結合網(wǎng)絡藥理學方法對其作用機制進行了初步探討。通過臨床觀察，我們發(fā)現(xiàn)二仙湯在治療腎陽虛型絕經(jīng)后骨質疏松癥方面具有顯著療效，能夠明顯改善患者的臨床癥狀和骨密度，且安全性較高。Thisstudyprovidesanin-depthevaluationoftheclinicalefficacyofErxianTanginthetreatmentofpostmenopausalosteoporosiswithkidneyyangdeficiency,andexploresitsmechanismofactionthroughnetworkpharmacologymethods.Throughclinicalobservation,wefoundthatErxianTanghassignificanttherapeuticeffectsinthetreatmentofpostmenopausalosteoporosiswithkidneyyangdeficiency.Itcansignificantlyimprovetheclinicalsymptomsandbonedensityofpatients,andhashighsafety.在機制研究中，我們利用網(wǎng)絡藥理學方法，對二仙湯中的活性成分及其潛在作用靶點進行了預測和分析。結果顯示，二仙湯中多種活性成分能夠作用于與骨質疏松癥相關的多個關鍵靶點，從而發(fā)揮治療作用。這一發(fā)現(xiàn)為二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的機制提供了科學依據(jù)。Inthemechanismresearch,weusednetworkpharmacologymethodstopredictandanalyzetheactiveingredientsandpotentialtargetsofErxianTang.TheresultsshowthatmultipleactiveingredientsinErxianTangcanactonmultiplekeytargetsrelatedtoosteoporosis,therebyexertingtherapeuticeffects.ThisdiscoveryprovidesascientificbasisforthemechanismofErxianTangintreatingpostmenopausalosteoporosiswithkidneyyangdeficiency.二仙湯作為一種傳統(tǒng)中藥方劑，在治療腎陽虛型絕經(jīng)后骨質疏松癥方面具有顯著的臨床療效，其機制可能與多成分、多靶點的協(xié)同作用有關。本研究為二仙湯在臨床治療骨質疏松癥的應用提供了有力支持，也為進一步深入研究其作用機制奠定了基礎。未來，我們將繼續(xù)深入研究二仙湯的具體作用機制，以期為其臨床應用提供更加科學、合理的依據(jù)。ErxianTang,asatraditionalChinesemedicineformula,hassignificantclinicalefficacyintreatingpostmenopausalosteoporosiswithkidneyyangdeficiency.Itsmechanismmayberelatedtothesynergisticeffectofmultiplecomponentsandtargets.ThisstudyprovidesstrongsupportfortheclinicalapplicationofErxianTanginthetreatmentofosteoporosis,andalsolaysthefoundationforfurtherin-depthresearchonitsmechanismofaction.Inthefuture,wewillcontinuetoconductin-depthresearchonthespecificmechanismofactionofErxianTang,inordertoprovidemorescientificandreasonablebasisforitsclinicalapplication.八、致謝Thanks在完成本項關于《二仙湯治療腎陽虛型絕經(jīng)后骨質疏松癥的臨床療效評價及基于網(wǎng)絡藥理學的機制研究》的研究過程中，我們得到了多方面的支持與幫助，在此表示衷心的感謝。IntheprocessofcompletingtheresearchontheclinicalefficacyevaluationandmechanismresearchbasedonnetworkpharmacologyofErxianTanginthetreatmentofpostmenopausalosteoporosiswithkidneyyangdeficiency,wehavereceivedsupportandassistancefromvariousaspects.Wewouldliketoexpressoursinceregratitude.我們要感謝國家中醫(yī)藥管理局和各級科研基金對本研究的資助，使我們有幸能夠深入研究這一課題，為中醫(yī)藥在骨質疏松癥治療領域的應用提供新的思路和證據(jù)。WewouldliketoexpressourgratitudetotheStateAdministrationofTraditionalChineseMedicineandsc