版權(quán)說明：本文檔由用戶提供并上傳，收益歸屬內(nèi)容提供方，若內(nèi)容存在侵權(quán)，請進(jìn)行舉報或認(rèn)領(lǐng)
文檔簡介
PharmaSUGOsaka2023
AutomaticGenerationofPythonProgramsforCreatingSDTMDatasets
FUJITSULIMITED
?2023FujitsuLimited.
PAGE
2
?2023FujitsuLimited.
Disclaimer
Theviewsandopinionsexpressedinthispresentationarethoseoftheauthor(s)anddonotnecessarilyreflecttheofficialpolicyorpositionoftheorganizationwheretheauthorbelongs.
AboutThisPresentation
ThemaintopicofthispresentationisautomaticgenerationofPython
programsforcreatingCDISCSDTMdatasets.
Beforedivingintothemaintopic,thispresentationwillexplain:
WhyPythonisagoodoptionfordatascienceindrugdevelopment
HowprogrammingpracticeischangingwithGenerativeAI
HowDigitalDataFlowisimpactingapproachtodataprocessing
BackgroundandTrends
4 ?2023FujitsuLimited.
PAGE
12
?2023FujitsuLimited.
PopularityofSAS,RandPython
Astudyconductedin2020for1,000datascientistsintheUnitedStatesshowedthatPython
wasthemostpopularlanguageamongSAS,RandPython,inanyindustry.
ItalsoshowsthatPythonismorepopularinyoungergeneration(withlessyearsofexperienceindatascience).
Reference:BurtchWorksLLC"
2020SAS,R,orPythonSurveyResults:WhichTooldoDataScientists&AnalyticsProsPrefer?
"
GenerativeAI
GenerativeAI(morepreciselyLLM:LargeLanguageModel)issignificantlychangingthewayhowprogramsaredeveloped.
CodeGeneration
CodeCompletion
TestCodeGenerationandmore
ChatGPT,themostfamousLLM-basedgenerativeAI,isbuiltwithPythonandbestatgeneratingPythoncodesamongotherlanguages.
AnotherfamousLLM-basedgenerativeAI,Copilot,istrainedonalllanguagesthatappearinpublicrepositories(seethetop50pullrequestsinQ3of2023ontheleft).
AdvancedDataAnalytics
AdvanceddataanalysisisanotherpowerfulfeatureofChatGPTthatallowsuploadingfiles,
writeandexecutePythoncodes,andcreategraphswithinstructionsinnaturallanguage.
DigitalDataFlow(DDF)Overview
DigitalDataFlow(DDF)isaninitiativebyTransCeleratethataimstocreatedigitizedstudy
protocolandautomatecreationofstudyassets.
Studybuildersordigitalprotocolauthoringtools
Centralrepositoryofdigitizedstudyprotocol
Automatedownstreamdocumentsandsystems
CDISCiscollaboratingwithTransCeleratetodevelopastandardmodelforStudyDefinitionsRepositoryaspartoftheirjourneytoachieveend-to-endautomation.
Note:ThecontentinthisslidehasbeencreatedbysummarizingcontentsontheTransCeleratewebsiteattheauthor’sowndiscretion.
DDFAchievesMoreSDTMAutomation
(2)ActivitieswithBCsaremappedtoformswhenadrafteCRFSpeciscreatedfromSDR.
(3)ActivitieswithBCsaremappedtoSDTMdomainswhenadraftSDTMSpeciscreatedfromSDR.
(1)Activities/BCsarepopulatedviaStudyBuilderorreadfromStudyProtocol.
StudyBuilder
Protocol
SDR
eCRFSpec SDTMSpec
BCs
BCs
AutomatedMapping
Generate
SDTM
Datasets
SDTM
BiomedicalConcepts(BC)
(4)SDRknowswhichBCsare
referencedfromwhichforms/domains
DigitalDataFlow
MetadataRepository
DDFandGenerativeAI
Dotheyconflictorcomplementtoeachother?
DigitalDataFlow
Protocol CRFSpec
SDTMSpec
SDTMDatasets
StatisticalAnalysisPlan
MockShells
ADaMSpec ADaMDatasets TLFs StudyReport
CDISCOak–SDTMAutomationinR
Awell-knownexampleofR-basedSDTMautomation
OnlyasAlgorithms
OnlyasSub-Algorithms
Algorithm&Sub-Algorithms
03_AE_AEREL
11_MERGE
01_ASSIGN_NO_CT
07_DATASET_LEVEL
18_REMOVE_DUP
02_ASSIGN_CT
09_IF_THEN_ELSE
19_GROUP_BY
05_HARDCODE_CT
17_WHODRUG_FA
20_NEED_USER_INPUT
06_HARDCODE_NO_CT
13_RELREC
08_NOTSUBMITTED
14_RELREC_CONDITION
15_MULTIPLE_RESPONSES
21_NONCRF_LAB
22_NONCRF_PKC
23_PAIRED_VARS
Upto22ReusableAlgorithms
Reference:F.Hoffmann-LaRocheAG"
OAKGarden-SDTMAutomationTheflourishingDataTransformationEngine
"
FujitsutsClinicalforSDTMAutomation
CRFandeDTSpecs
SDTMSpec
StandardsandTerminologies
TrialDesign
SimilarcomponentsandprocessestoOAKGarden,butmorevarietyofmethods.
MetadataRepository
TransformationEngine
RunsonOracleand.NET
AnnotatedCRF
BiomedicalConcepts
SDTM
Datasets
Transformation
Engine
SDTMSpec
(Executable)
Define-XML
TopicMethods
assignTopiccopycopyDesigncopyUniqueextrtjoinUniquelookupConcept
lookupConceptNormalizedlookupDomainREGEXn1mapTopic
se
sv
Non-TopicMethods
blflcalccoeval
commentconcatconcatDateconvertToStdcopycopyDesigncopyIfcopyToSUPP
…andmore
55Methodsand286UseCases**
**:Pre-configuredmethodcalls
AddingPythonImplementationtotsClinical
The55methodsarebeingimplementedinPython.
MetadataRepository
TransformationEngine
RunsonOracleand.NET
AnnotatedCRF
TransformationinPython
BiomedicalConcepts
SDTM
Datasets
Transformation
Engine
SDTMSpec
(Executable)
Define-XML
CRFandeDTSpecs
SDTMSpec
StandardsandTerminologies
TrialDesign
Pythoncurrentlyimplementedforreal-timemappingreviewasSDTMspecisedited.
Summary
GenerativeAIismultipurpose,andthusyourideasmattertomakeitvaluable.
PythonsitsinauniquepositionintheAIera.
DigitalDataFlowisbuiltonCDISCstandardsandhasgoodfamiliaritywithdataprocessing.
Afterall,therearemanychancesofautomationinyourjobwiththe
riseofLLM-basedgenerativeAIandDigitalDataFlow.
Exercise
CRFandeDTSpecs
SDTMSpec
StandardsandTerminologies
TrialDesign
Whichpartoftheprocessbe
溫馨提示
- 1. 本站所有資源如無特殊說明，都需要本地電腦安裝OFFICE2007和PDF閱讀器。圖紙軟件為CAD,CAXA,PROE,UG,SolidWorks等.壓縮文件請下載最新的WinRAR軟件解壓。
- 2. 本站的文檔不包含任何第三方提供的附件圖紙等，如果需要附件，請聯(lián)系上傳者。文件的所有權(quán)益歸上傳用戶所有。
- 3. 本站RAR壓縮包中若帶圖紙，網(wǎng)頁內(nèi)容里面會有圖紙預(yù)覽，若沒有圖紙預(yù)覽就沒有圖紙。
- 4. 未經(jīng)權(quán)益所有人同意不得將文件中的內(nèi)容挪作商業(yè)或盈利用途。
- 5. 人人文庫網(wǎng)僅提供信息存儲空間，僅對用戶上傳內(nèi)容的表現(xiàn)方式做保護(hù)處理，對用戶上傳分享的文檔內(nèi)容本身不做任何修改或編輯，并不能對任何下載內(nèi)容負(fù)責(zé)。
- 6. 下載文件中如有侵權(quán)或不適當(dāng)內(nèi)容，請與我們聯(lián)系，我們立即糾正。
- 7. 本站不保證下載資源的準(zhǔn)確性、安全性和完整性, 同時也不承擔(dān)用戶因使用這些下載資源對自己和他人造成任何形式的傷害或損失。
最新文檔
- DB3709-T 015-2022 肥城桃 桃園綠肥栽培技術(shù)規(guī)范
- 13 人物描寫一組《兩莖燈草》（教學(xué)設(shè)計）-2023-2024學(xué)年語文五年級下冊統(tǒng)編版
- 3《電和磁》（教學(xué)設(shè)計）-2024-2025學(xué)年科學(xué)六年級上冊教科版
- 某植物園改造工程施工組織
- 2016年秋九年級化學(xué)上冊 4 物質(zhì)構(gòu)成的奧秘教學(xué)實(shí)錄 （新版）新人教版
- 25少年潤土（教學(xué)設(shè)計）-2024-2025學(xué)年統(tǒng)編版語文六年級上冊
- 2024-2025學(xué)年新教材高中英語 Unit 4 Everyday economics預(yù)習(xí) 新知早知道2（教用文檔）教學(xué)實(shí)錄 外研版選擇性必修第四冊
- 2學(xué)會寬容（教學(xué)設(shè)計）統(tǒng)編版道德與法治六年級下冊
- 2024-2025學(xué)年高中歷史 專題一 古代中國的政治制度 1.1《中國早期政治制度的特點(diǎn)》教學(xué)實(shí)錄 人民版必修1
- 6《狼牙山五壯士》（教學(xué)設(shè)計）-2024-2025學(xué)年統(tǒng)編版語文六年級上冊
- 機(jī)動絞磨安全操作規(guī)程范本
- 初中體育與健康八年級全一冊第一章 體育與健康理論知識科學(xué)發(fā)展體能
- 2024醫(yī)療衛(wèi)生機(jī)構(gòu)安全生產(chǎn)與消防安全知識考試試題及答案
- 橋梁工程地基與基礎(chǔ)的試驗(yàn)檢測-鉆（挖）孔灌注樁檢測
- 鄉(xiāng)鎮(zhèn)街道安全巡查員培訓(xùn)
- DL-T 2578-2022 沖擊式水輪發(fā)電機(jī)組啟動試驗(yàn)規(guī)程
- 勞動教育-專題一崇尚勞動(勞動的意義)
- 自然辯證法概論-第4章(2018新大綱)
- 23年-制袋車間管理制度
- 人教版初中英語七八九全部單詞(打印版)
- 房屋拆除工程投標(biāo)方案（技術(shù)標(biāo)）
評論
0/150
提交評論