nor-NOHA-Nω-Hydroxy-nor-L-arginine-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEnor-NOHACat.No.:HY-112885CASNo.:189302-40-7Synonyms:Nω-Hydroxy-nor-L-arginine分?式:C?H??N?O?分?量:176.17作?靶點(diǎn):Apoptosis;Arginase作?通路:Apoptosis;Immunology/Inflammation;MetabolicEnzyme/Protease儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)H2O:250mg/mL(1419.08mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM5.6763mL28.3817mL56.7634mL5mM1.1353mL5.6763mL11.3527mL10mM0.5676mL2.8382mL5.6763mLBIOLOGICALACTIVITY?物活性nor-NOHA?種選擇性的，可逆的arginase抑制劑。nor-NOHA在缺氧條件誘導(dǎo)ARG2表達(dá)細(xì)胞的凋亡(apoptosis)。nor-NOHA有抗??病的活性。nor-NOHA可?于研究內(nèi)?功能障礙、免疫抑制及代謝[1][2]。體外研究nor-NOHA(0.1-1mM,72h)inducesapoptosisinadose-dependentmannerunderhypoxia(1.5%O2)inK562cells[1].nor-NOHA(1mM,72h)attenuateshypoxia-mediatedresistancetowardsimatinibinK562orKCL22cells[1].體內(nèi)研究nor-NOHA(100mg/kg,i.v.,oncetime)inducesasignificantreductionofinfarctsizeinmaleSprague-Dawley1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemErats[2].nor-NOHA(100mg/kg,i.v.,oncetime)increasesplasmacitrullineandnitritelevelsanddecreasestheornithineplasmalevelsinmaleSprague-Dawleyrats[2].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?FrontCellDevBiol.2021Dec23;9:741911.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].NgKP,etal.ThearginaseinhibitorNω-hydroxy-nor-arginine(nor-NOHA)inducesapoptosisinleukemiccellsspecificallyunderhypoxicconditionsbutCRISPR/Cas9excludesarginase2(ARG2)asthefunctionaltarget.PLoSOne.2018Oct11;13(10):e0205254.[2].JungC,etal.Arginaseinhibitionmediatescardioprotectionduringischaemia-reperfusion.CardiovascRes.2010Jan1;85(1):147-54.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379