藥學(xué)英語(yǔ)III智慧樹知到答案2024年山東中醫(yī)藥大學(xué)

藥學(xué)英語(yǔ)III山東中醫(yī)藥大學(xué)智慧樹知到答案2024年第一章測(cè)試

Which

of

the

following

parts

of

knowledge

of

drugs

should

be

included

in

pharmacology?

（

）

A:The

effects

of

drugs

on

manB:The

correlation

of

biological

activity

with

chemical

structureC:The

history,

source,

physical

and

chemical

properties,

compounding,

biochemical

and

physiological

effects,

mechanisms

of

action,

absorption,

distribution,

biotransformation

and

excretion.D:The

prevention,

recognition,

and

treatment

of

drug

poisonings.

答案:CWhich

of

the

following

is

what

a

clinician

is

primarily

interested

in

according

to

the

text?

(

)

A:Drugs

which

help

resolve

the

continuing

abuse

of

drug.B:Drugs

which

are

useful

in

the

prevention,

diagnosis

and

treatment

of

human

disease,

or

in

the

prevention

of

pregnancy.C:Chemical

agents

that

are

not

used

in

therapy

but

are

commonly

responsible

for

household

and

industrial

poisoning

as

well

as

environmental

pollution.D:Drugs

which

can

be

reasonably

limited

to

those

aspects

that

provide

the

basis

for

their

rational

clinical

use.

答案:BWhy

was

the

physician

not

interested

in

pharmacognosy?

(

)

A:Natural

drugs

had

little

difference

with

synthetic

onesB:He

had

a

broad

botanical

knowledgeC:Fewer

drugs

were

obtained

from

natural

sourcesD:He

didn't

have

to

select

the

proper

plants

for

his

prescription.

答案:AWhich

of

the

following

is

the

best

way

of

studying

pharmacology

for

medical

students

and

practitioners?

(

)

A:to

select

a

plant

and

its

preparationB:to

have

the

ability

to

purify

natural

plantsC:to

have

a

broad

botanical

knowledgeD:to

have

curiosity

that

stimulates

them

to

learn

about

sources

of

drugs

答案:DWhat

are

the

tasks

related

to

medicines

almost

completely

delegated

to

the

pharmacists

now?

(

)

A:the

preparing,

compounding,

and

dispensing

of

medicinesB:the

physical

and

chemical

properties

of

medicinesC:the

therapeutic

and

other

uses

of

medicinesD:dosage

forms

of

medicines

available

答案:A

第二章測(cè)試

H.

Mario

Geysen

initially

used

parallel

synthesis

as

a

quick

way

to

identify

which

small

(

)

of

any

given

large

protein

bound

to

an

antibody.

A:partB:FragmentC:divisionD:pieces

答案:CChemists

often

start

a

combinatorial

synthesis

by

attaching

the

first

set

of

building

blocks

to

(

),

microscopic

beads

made

of

polystyrene.

A:solid

B:ActiveC:softD:inert

答案:CThe

chemical

reactions

required

to

link

compounds

to

the

beads

and

later

to

detach

them

(

)

to

the

synthesis

process.

A:introduce

complicationsB:make

easyC:introduce

easyD:induce

complications

答案:BIn

a

parallel

synthesis,

all

the

products

are

(

)

separately

in

their

own

reaction

vessels.

A:assembledB:AssortedC:joinedD:combined

答案:BIn

many

laboratories

today,

robots

assist

with

the

routine

work

of

parallel

synthesis,

such

as

(

)

small

amounts

of

reactive

molecules

into

the

appropriate

wells.

A:deliveringB:transportingC:givingD:sending

答案:C

第三章測(cè)試

Pharmaceutics

is

an

interdisciplinary

subject

involving

(

)

A:manufacturingB:physical

pharmacyC:formulation,

manufacturing,

physical

pharmacy,

and

biopharmaceuticsD:Biopharmaceutics

答案:CFormulation

is

about

the

design,

development

and

evaluation

of

dosage

forms,

(

)

A:analytical

methodsB:discovery

of

novel

drugsC:drug

delivery

systems

and

manufacturing

processD:dosing

regimen

答案:CBiopharmaceutics

mainly

studies

the

in

vivo

process

of

drugs

and

metabolites

in

humans,

animals

and

tissue

culture,

which

specifically

involves

(

)

A:absorption

and

excretionB:absorption

and

distributionC:metabolism

and

excretionD:absorption,

distribution,

metabolism,

and

excretion

答案:DRegarding

the

definition

of

bioavailability

(BA),

BA

is

related

to

(

)

A:total

plasma

drug

concentration,

and

the

administered

drug

doseB:unbound

drug

concentration

at

the

target

siteC:unbound

drug

concentration

in

the

plasmaD:total

plasma

drug

concentration

only

答案:APlasma

drug

concentration

is

affected

by

following

factors

such

as

(

)

A:all

of

aboveB:rate

of

eliminationC:rate

and

extent

of

distributionD:rate

of

absorption

答案:A

第四章測(cè)試

Blood

(

)

must

be

monitored

in

diabetics

(and,

in

fact,

most

diseases

are

diagnosed

by

chemical

analysis).

A:glucos

B:ProteinC:B

PHD:hemoglobin

答案:AIn

medicine,

analytical

chemistry

is

the

basis

for

(

)

laboratory

tests

which

help

physicians

diagnose

disease

and

chart

progress

in

recovery.

A:clinicalB:FuelC:agriculturalD:polymer

答案:AIn

industry,

analytical

chemistry

provides

the

means

of

testing

raw

materials

and

for

assuring

the

quality

of

finished

products

whose

chemical

(

)

is

critical.

A:compoundB:concentrationC:ClassD:composition

答案:D(

)

quality

is

often

evaluated

by

testing

suspected

contaminants

using

the

techniques

of

analytical

chemistry.

A:NutritionalB:EngineeringC:EnvironmentalD:Agricultural

答案:CThe

formation

of

a

white

precipitate

when

adding

a

solution

of

silver

nitrate

to

a

dissolved

sample

indicates

the

presence

of

(

).

A:sulfideB:nitrateC:chlorideD:Sulfate

答案:C(

)

spectra

will

give

"fingerprints"

of

organic

compounds

or

their

functional

groups.

A:MassB:VisibleC:InfraredD:Ultraviolet

答案:CChromatography

provides

powerful

(

).

A:precipitationB:instrumentationC:extractionD:Separation

答案:DThe

list

of

prohibited

substances

at

the

Olympic

Games

includes

about

500

different

active

constituents,

such

as

(

).

A:stimulantsB:beta-blockersC:all

of

the

aboveD:steroids

答案:CDoped

compounds

are

identified

using

the

highly

selective

combination

of

gas

(

)-mass

spectrometry

(GC-MS).

A:ChromatographyB:concentrationC:phaseD:flow

答案:A(

)

spectrometry

provides

molecular

structural

data

on

the

compounds.

A:MassB:UltravioletC:InfraredD:Visible

答案:A

第五章測(cè)試

What

is

the

meaning

of

HTS?

(

)

A:High

Temperature

SuperconductingB:Heat

Transfer

SaltsC:High

Throughput

ScreeningD:Heat-treated

Steel

答案:CWhat

category

does

simvastatin

belong

to?

（

）

A:antibiotics

of

aminoglycosidesB:AnalgesicsC:antineoplastic

agentsD:lipid

regulating

agents

答案:DWhat

category

does

paclitaxel

belong

to?

(

)

A:antibiotics

of

aminoglycosidesB:AnalgesicsC:lipid

regulating

agentsD:antineoplastic

agents

答案:DWhat

category

does

azithromycin

belong

to?

(

)

A:lipid

regulating

agentsB:antibiotics

of

macrolidesC:antineoplastic

agentsD:analgesics

答案:B90%to95%of

plants

on

this

planet

have

not

been

investigated

so

far.

（

）

A:錯(cuò)B:對(duì)

答案:BTo

incorporate

natural

products

in

the

modern

HTS

programmes,

a

natural

product

library

is

not

useful.

（

）

A:對(duì)B:錯(cuò)

答案:BNatural

products

have

been

a

source

of

drugs

and

drug

leads.

（

）

A:對(duì)B:錯(cuò)

答案:AThe

traditional

way

of

discovering

drug

from

natural

product

is

bioassay-guided.

（

）

A:對(duì)B:錯(cuò)

答案:AAcademia

and

some

semi-academic

research

organizations

usually

apply

modern

approaches

to

natural

product

drug

discovery.

（

）

A:對(duì)B:錯(cuò)

答案:BCephalosporin

C

is

an

antiviral

compound.

（

）

A:對(duì)B:錯(cuò)

答案:B

第六章測(cè)試

(

)

is

generally

directly

related

to

uncertainty

and

is

reduced

through

knowledge

and

best

scientific

practices.

A:SafetyB:ImmunogenicityC:SpecificityD:Efficacy

答案:ABecause

of

the

(

)

of

the

compound

class,

our

future

nonclinical

development

programs

must

be

considered

largely

on

a

case-by-case

basis.

A:specificity

B:toxicityC:SafetyD:heterogeneity

答案:DAdequate

exposure

needed

for

specific

treatment

regimens

can

be

hindered

by

the

formation

of

(

)

with

drug

neutralization

or

accelerated

clearance.

A:antigensB:CytokinesC:antibodies

D:antidrug

antibodies

答案:DToxicology

programs

with

(

)

administration

of

biologics

often

have

less

long-term

treatments

than

SMDS.

A:properB:single-dose

C:large-doseD:multiple-dose

答案:DAs

in

the

case

for

small

molecules,

some

toxicological

studies

have

to

be

performed

before

first

use

in

humans.

（

）

A:錯(cuò)B:對(duì)

答案:ASmall

molecules

generally

do

not

necessarily

need

a

PK

assay

for

quantification

of

the

unchanged

compound

and

its

(major)

metabolite(s).

（

）

A:錯(cuò)B:對(duì)

答案:Asample-clean

procedures

routinely

used

for

small

molecules

cannot

usually

be

used

for

biologics.

（

）

A:對(duì)B:錯(cuò)

答案:AEssential

reagents

such

as

poly-

or

monoclonal

antibodies

might

not

be

difficult

to

obtain

in

the

early

stages

of

development.

（

）

A:錯(cuò)B:對(duì)

答案:AThe

activity

assay

is

particularly

useful

for

measuring

the

neutralizing

activity

of

an

ADA,

although

it

was

originally

developed

to

measure

product

efficacy.

（

）

A:對(duì)B:錯(cuò)

答案:ATissue

cross-reactivity

(TCR)

studies

in

a

panel

of

human

tissues

determining

the

level

of

cross-recognition

are

necessary

for

targeted

biologics

such

as

mAbs.

（

）

A:對(duì)B:錯(cuò)

答案:A

第七章測(cè)試

(

)

increases

risk

of

bleeding.

A:Excessive

coagulationB:Insufficient

anticoagulationC:Insufficient

warfarinD:Excessive

warfarin

答案:DWhich

of

the

following

statements

is

TRUE?

(

)

A:A

drug

will

certainly

be

efficacious

in

actual

use

if

it

was

already

proved

in

clinical

trials.B:A

drug

that

is

proved

effective

in

a

clinical

trial

will

have

similar

effectiveness

in

actual

use.C:Drugs

that

are

efficacious

in

clinical

trials

may

not

be

very

effective

in

clinical

uses.D:A

drug

that

is

efficacious

in

clinical

trials

will

always

be

not

very

effective

in

actual

use.

答案:CWhich

of

following

elements

is

not

involved

in

Patient-oriented

outcomes?

(

)

A:concentrations

of

cholesterolB:relief

of

symptomsC:prevention

of

disabilityD:prolongation

of

life

答案:AClinicians

often

consider

factors

that

are

somewhat

(

),

such

as

personal

experience,

anecdotes,

peer

practices,

and

expert

opinions.

A:objectivelyB:objectiveC:subjectivelyD:subjective

答案:DThe

intuitive

standard

used

for

the

measurement

of

efficacy

and

safety

in

medical

history

are

no

longer

used

today.

（

）

A:對(duì)B:錯(cuò)

答案:BUnlike

effectiveness,

efficacy

cannot

be

evaluated

accurately

even

in

an

ideal

environment.

（

）

A:對(duì)B:錯(cuò)

答案:BSurrogate

outcomes

are

preferred

measures

of

efficacy

than

patient-oriented

outcomes,

because

they

can

be

much

more

feasible

to

use.

（

）

A:錯(cuò)B:對(duì)

答案:AAdverse

effects

may

only

be

fully

known

after

a

drug

has

been

in

widespread

clinical

use

for

a

long

time.

（

）

A:錯(cuò)B:對(duì)

答案:BEven

a

drug

that

causes

many

more

harms

than

benefits,

it

may

still

be

worth

prescribing

to

patients.

（

）

A:錯(cuò)B:對(duì)

答案:BA

drug

with

wide

therapeutic

window

is

often

safer

than

those

with

narrow

ones.

（

）

A:錯(cuò)B:對(duì)

答案:B

第八章測(cè)試

(

)

is

the

drug

regulatory

agency

in

the

UK.

A:CFDAB:MHRAC:FDAD:EMA

答案:BWhich

of

the

following

statements

about

the

US

and

the

UK

requirements

on

GMP

is

NOT

true?

(

)

A:The

US

required

all

drugs

should

be

manufactured

according

to

GMP

requirementsB:The

US

GMP

has

the

force

of

lawC:The

UK

GMP

was

mandatoryD:The

UK

only

inspected

drug

products

and

biological

manufacturers

答案:CWhich

of

the

following

statements

on

the

manufacture

of

API

is

NOT

true?

(

)

A:The

manufacturing

processes

involve

purification

at

each

stageB:An

API

is

normally

prepared

by

chemical

processesC:Impurities

present

in

final

API

will

be

removedD:The

impurities

in

API

will

not

influence

the

quality

of

drug

product

答案:C“Starting

material”

includes

(

)

A:both

A

and

BB:raw

materialC:excipientsD:paIckaging

material

答案:AGMP

compliance

is

a

requirement

only

for

the

manufacture

of

drug

products.

（

）

A:對(duì)B:錯(cuò)

答案:BAccording

to

FD&C

Act,

only

drug

products

shall

be

manufactured

in

accordance

with

cGMP.

（

）

A:錯(cuò)B:對(duì)

答案:AICH

Q7

A

is

a

worldwide

guidance

for

the

manufacture

of

drug

products

for

both

commercial

and

R&D

purposes.

（

）

A:錯(cuò)B:對(duì)

答案:BSame

as

that

in

the

USA,

all

drug

products

are

inspected

by

the

regulatory

authority

for

compliance

to

GMP

in

the

UK.

（

）

A:錯(cuò)B:對(duì)

答案:AImpurities

in

the

final

API

will

be

removed

because

it

will

influence

the

quality

of

drug

products.

（

）

A:對(duì)B:錯(cuò)

答案:BEach

stage

of

A

PI

production

will

influence

the

quality

of

final

API.

（

）

A:錯(cuò)B:對(duì)

答案:A

第九章測(cè)試

Which

of

the

following

statements

is

right

according

to

the

passage?

(

)

A:There

is

a

relationship

between

the

significance

of

the

contraindications

and

the

likelihood

of

occurrence

and

the

size

of

population.B:Adverse

reaction

is

usually

included

in

Highlights

of

Prescribing

Information

section.C:That

there

are

no

known

contraindications

for

a

drug

means

therapeutical

benefits

outweigh

risks.D:Both

known

dangers

and

theoretical

possibilities

should

be

listed

in

“Contraindications”.

答案:AIn

a

drug

insert,

pharmacokinetic

effects

are

included

in

(

)

section

A:Recent

Major

ChangesB:ContraindicationsC:Drug

InteractionD:FPI

Contents

答案:CSome

information

in

FPI

Contents

section

is

cross-referenced

in

(

)

section.

A:Highlights

of

Prescribing

InformationB:ContraindicationsC:Black

Box

WarningD:Warnings

and

Precautions

答案:AWhen

the

ADR

requires

adjusting

drug

dosage

or

regimen,

discontinuing

the

drug

and

evaluating

the

patient

for

medication

compliance,

it

means

that

the

ADR

associated

with

use

of

the

drug

is

(

).

A:clinically

insufficientB:clinically

sufficientC:clinically

significantD:clinically

insignificant

答案:CIn

the

1980s,

health

practitioners

found

i