Procyanidin-B3-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEProcyanidinB3(Standard)Cat.No.:HY-N2345RCASNo.:23567-23-9分?式:C??H??O??分?量:578.52作?靶點(diǎn):HistoneAcetyltransferase;Toll-likeReceptor(TLR);AndrogenReceptor作?通路:Epigenetics;Immunology/Inflammation;VitaminDRelated/NuclearReceptor儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性ProcyanidinB3(Standard)ProcyanidinB3的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。ProcyanidinB3是?種天然產(chǎn)物，具有抗氧化活性和?服有效性，具有良好的?腦屏障穿透性。ProcyanidinB3組蛋??酰轉(zhuǎn)移酶(HAT)選擇性抑制劑。通過抑制p300HAT介導(dǎo)的雄激素受體(androgenreceptor)??；?。ProcyanidinB3通過抑制TLR4/MD-2復(fù)合體形成來緩解椎間盤退變(IVDD)。ProcyanidinB3可?于前列腺癌和關(guān)節(jié)炎領(lǐng)域研究[1][2][3][4][5]。IC50&Targetp300[1]REFERENCES[1].ChoiKC,etal.ProcyanidinB3,aninhibitorofhistoneacetyltransferase,enhancestheactionofantagonistforprostatecancercellsviainhibitionofp300-dependentacetylationofandrogenreceptor.BiochemJ.2011Jan1;433(1):235-44.[2].AiniH,etal.ProcyanidinB3preventsarticularcartilagedegenerationandheterotopiccartilageformationinamousesurgicalosteoarthritismodel[J].PLoSOne,2012,7(5):e37728.[3].MizunoM,etal.SynthesisandantioxidantactivityofaprocyanidinB3analogue.BioorgMedChemLett.2017Feb15;27(4):1041-1044.[4].ShangP,etal.ProcyanidinB3alleviatesintervertebraldiscdegenerationviainteractionwiththeTLR4/MD-2complex.JCellMolMed.2020Mar;24(6):3701-3711.[5].MizunoM,etal.Inhibitionofβ-amyloid-inducedneurotoxicitybyplanaranaloguesofprocyanidinB3.BioorgMedChemLett.2019Sep15;29(18):2659-2663.McePdfHeight1/1MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0