enterobacteriaceae, vibrio, campylobacter and helicobacter.ppt

Faculty Dr AlvinFox ENTEROBACTERIACEAE VIBRIO CAMPYLOBACTERANDHELICOBACTER 天馬行空官方博客 KeyWords OpportunisticdiseasesShigellaDiarrhea DysenteryBacillarydysenteryUrinarytractinfectionsShigatoxinOpportunisticinfectionsSalmonellaenteritidisLactosepositive negativesalmonellosisEnteropathogenicE coliSalmonellacholerae suisEnterotoxigenicE coliSalmonellatyphiHeatstabletoxinTyphoidHeatlabiletoxinViEnteroinvasiveE coliVibriocholeraeEnterohemorrhagicE coliCholeragenVerotoxin Shiga like YersiniaentercoliticaHemolysinHelicobacterpyloripiliCampylobacterjejuni septicemia pneumonia meningitisurinarytractinfections CitrobacterEnterobacterEscherichiaHafniaMorganellaProvidenciaSerratia Opportunisticdiseases Enterobacteriaceae 天馬行空官方博客 Enterobacteriaceae gastrointestinaldiseasesEscherichiacoliSalmonellaShigellaYersiniaentercolitica Histocompatibilityantigen HLA B27EnterobacteriaceaeSalmonellaShigellaYersinia NotEnterobacteriaceaeCampylobacterChlamydia Reiter ssyndrome 天馬行空官方博客 communityacquiredotherwisehealthypeopleKlebsiellapneumoniaerespiratorydiseasesprominentcapsuleurinarytractinfectionfecalcontaminationE coliProteusurease degradesurea alkalineurine Enterobacteriaceae Enterobacteriaceae gramnegativefacultativeanaerobicrods oxidasenegative nocytochromeoxidase Emon healthyintestineShigella Salmonella Yersinialactosenegativeidentified Feces othersitesidentifiedbiochemically Enterobacteriaceae Serotypes referencelaboratoryantigensO lipopolysaccharide H flagellar K capsular DiarrheaandDysentery Escherichiacoli E coliandShigellageneticallyindistinguishablemanysimilaritiesindiseases Escherichiacoli EnteropathogenicE coli destructionofsurfacemicrovilli feverdiarrheavomitingnauseanon bloodystools EnterotoxigenicE coli diarrhealikecholeramildertravellersdiarrhea EnterotoxigenicE coli HeatlabiletoxinlikecholeragenAdenylcyclaseactivatedcyclicAMPsecretionwater ionsHeatstabletoxinGuanylatecyclaseactivatedcyclicGMPuptakewater ions EnteroinvasiveE coli EIEC Dysentery resemblesshigellosis EnterohemorrhagicE coli UsuallyO157 H7 Transmissionelectronmicrograph Meat Hemorrhagicbloody copiousdiarrheafewleukocytesafebrilehemolytic uremicsyndromehemolyticanemiathrombocytopenia lowplatelets kidneyfailure Verotoxin shiga like Hemolysins EnterohemorrhagicE coli Treatment gastrointestinaldisease fluidreplacementantibioticsnotusedusuallyunlesssystemice g hemolytic uremiasyndrome E colifimbriae mannose Type1 galactoseglycolipidsglycoproteins P Shigella S flexneri S boydii S sonnei S dysenteriaebacillarydysenteryshigellosisbloodyfecesintestinalpainpus Shigellosis within2 3daysepithelialcelldamage Shigellasonnei Shigatoxin enterotoxiccytotoxicinhibitsproteinsynthesislysing28SrRNA Shigellosis manonly reservoir mostlyyoungchildrenfecaltooralcontactchildrentoadultstransmittedbyadultfoodhandlersunwashedhands Treatingshigellosis managedehydrationpatientsrespondtoantibioticsdiseasedurationdiminished Salmonella Salmonella 2000antigenic types geneticallysinglespeciesS entericadiseasecategoryS enteritidismanyserotypesS cholerae suisS typhi Salmonellosis S enteritidisthecommonsalmonellainfectionpoultry eggsnohumanreservoirGastroenteritisnauseavomitingnon bloodystoolself limiting 2 5days Salmonellosis uncomplicatedcases thevastmajority antibiotictherapynotuseful S cholerae suis muchlesscommonsepticemiaantibiotictherapyessential Typhoid entericfeverseverestsalmonelladiseaseSalmonellatyphirareinUSepidemicsthirdworldEuropehistorical Salmonellatyphi humanreservoircarrierstatecommoncontaminatedfoodwatersupplypoorsanitaryconditions Typhoid acutephase gastroenteritis gallbladdershedding weeks Septicemia occurs10 14dayslasts7days gastrointenteritis S typhi Vi capsular antigenprotective Typhoid Therapy AntibioticsessentialVaccinesineffective Yersiniosis YersiniaentercoliticagastroenteritisScandinaviacommonUScolderregions Yersiniosis transmissionfecalcontamination domesticanimalswatermilkmeat Yersinia Diarrheafeverabdominalpainantibiotictherapyrecommendedoccassionalbacteremia Yersinia isolation coldenrichment similarlessseveredisease Y pseudotuberculosis Vibriocholerae Vibrios Gramnegativerodscommashapedfacultativeanaerobesoxidasepositivesimplenutritionalrequirementsreadilycultivated Occurrence cholera thirdworldUSuncommontraveleringestionofsea food food feces waterfreshsalt Transmission V cholerae Cholera attachment Choleratoxin Choleragen BbindstogangliosidesprovideschannelforAAcatalysesADP ribosylationregulatorcomplexactivatesadenylatecyclase massivesecretionofions waterintogutlumen dehydrationanddeath therapyfluidreplacementantibiotictherapy vaccinationpartiallyeffectivenotgenerallyusedinternationaltravelers Cholera therapy rawsea foodgrowsbestinhighsaltnotcommoninUSdiarrhea Vibrioparahemolyticus CAMPYLOBACTER HELICOBACTER Gramnegativerodscurvedorspiralgeneticallyrelated Campylobacter C jejuni infectstheintestinaltractofanimalscattleandsheepmajorcauseofabortions Transmission milkmeatproducts Campylobacter Isolation Campylobacter microaerophilicgrowsbest42oC diarrheamalaisefeverabdominalpainusuallyself limitingantibioticsoccassionallybacteremiasmallminority Campylobacter symptoms stomachmucosaulcers Helicobacterpylori Urease Importantinneutralizingstomachacid Culture ureaseNH4 CO2mucosalendoscopyNH4radioactiveCO2breathafterfeedingradioactiveurea Diagnosis Helicobacter Therapy Helicobacter Antibioticscuresulcers Summarystatement san