免疫學(xué)部分習(xí)題0.docx

A 1 MALT內(nèi)的B細(xì)胞分化為漿細(xì)胞后主要分泌何種抗體 A IgA B IgGG C IgE D IgD E IgMD 2 機(jī)體抵抗病原微生物感染的功能稱為 A 免疫監(jiān)視 B 免疫自穩(wěn) C 免疫耐受 D 免疫防御 E 免疫識別C 3 T細(xì)胞識別的抗原必須具備 A T細(xì)胞表位和B細(xì)胞表位 B TCR和BCR C T細(xì)胞表位和限制位 D 連續(xù)性決定簇和功能性決定簇 E 構(gòu)象決定簇和順序決定簇C 4 除了免疫原性以外，抗原的特性還有 A 毒性 B 變態(tài)反應(yīng)原性 C 異嗜性 D 耐受性 E 抗原性A 5 人類B淋巴細(xì)胞分化成熟的場所是： A 骨髓 B 腔上囊 C 脾臟 D 胸腺 E 淋巴結(jié)C 6 機(jī)體免疫系統(tǒng)殺滅突變的腫瘤細(xì)胞的功能稱為 A 免疫防御 B 免疫應(yīng)答 C 免疫監(jiān)視 D 免疫穩(wěn)定 E 免疫識別B 7 IL-2主要有哪種細(xì)胞產(chǎn)生？ A Tc細(xì)胞 B TH細(xì)胞 C M D B細(xì)胞 E Ts細(xì)胞A 8 機(jī)體免疫系統(tǒng)識別和清除突變的細(xì)胞的功能稱為 A 免疫監(jiān)視 B 免疫自穩(wěn) C 免疫耐受 D 免疫防御 E 免疫識別E 9 IL-1主要由哪種細(xì)胞產(chǎn)生 A TH B TC C TDTH D TS E 巨噬細(xì)胞E 10 關(guān)于IgG的錯(cuò)誤敘述是 A 可分為四個(gè)亞類 B 可通過胎盤 C 抗原結(jié)合價(jià)為二價(jià) D CH2有補(bǔ)體C1q結(jié)合點(diǎn) E 經(jīng)木瓜蛋白酶水解后可獲得一個(gè)F（ab）2片段D 11 發(fā)現(xiàn)ABO血型抗原的學(xué)者是 A Jerne B Burnet C Medawar D Landsteiner E BehringC 12 無胸腺小鼠體內(nèi)缺乏 A 成熟樹突狀細(xì)胞 B 成熟B細(xì)胞 C 成熟T細(xì)胞 D 成熟單核細(xì)胞 E 成熟粒細(xì)胞D 13 存在于不同種屬之間的共同抗原稱為 A 異種抗原 B 交叉抗原 C 超抗原 D 異嗜性抗原 E 類屬抗原C 14 MHC分子參與細(xì)胞分化過程正確的是 A 造血干細(xì)胞分化為淋巴干細(xì)胞 B 淋巴干細(xì)胞分化為前T細(xì)胞 C 前T細(xì)胞分化為成熟T細(xì)胞 D 成熟T細(xì)胞分化為記憶T細(xì)胞 E 淋巴干細(xì)胞分化為B細(xì)胞E 15 編碼補(bǔ)體成分的基因位于: A TAP座位 B HLA-DR座位 C HLA-E座位 D HLA-A座位 E Bf座位D 16 補(bǔ)體經(jīng)典激活途徑的依次順序是 A C123456789 B C12456789 C C145236789 D C142356789 E C124356789E 17 補(bǔ)體固有成分中含量最低的是 A C3 B C8 C C1q D C5 E D因子C 18 刺激紅細(xì)胞產(chǎn)生的細(xì)胞因子為 A GM-CSF B G-CSF C EPO D M-CSF E TPOE 19 補(bǔ)體系統(tǒng)中D因子的功能是 A 使C3b滅活 B 作為C5轉(zhuǎn)化酶的基質(zhì) C 過敏毒素 D 趨化因子 E 將C3bB裂解為活化的C3bBb和BaD 20 B細(xì)胞記憶是B細(xì)胞再次遇到相同抗原時(shí)產(chǎn)生的 A 低效價(jià)、低親和力抗體的現(xiàn)象 B 低效價(jià)、高親和力抗體的現(xiàn)象 C 高效價(jià)、低親和力抗體的現(xiàn)象 D 高效價(jià)、高親和力抗體的現(xiàn)象 E 非特異性抗體的現(xiàn)象D 21 黏膜相關(guān)淋巴組織中的B細(xì)胞主要分泌 A IgG類抗體 B IgM類抗體 C IgE類抗體 D IgA類抗體 E IgD類抗體D 22 T細(xì)胞CD4分子識別MHC類分子的位點(diǎn)是 A 1區(qū) B 2區(qū) C 1區(qū) D 2區(qū) E 鏈D 23 TD抗原激活B細(xì)胞需要 A Tc細(xì)胞的輔助 B NK細(xì)胞的輔助 C 中性粒細(xì)胞的輔助 D Th細(xì)胞的輔助 E 肥大細(xì)胞的輔助A 24 HLA類基因編碼的產(chǎn)物是 A MHC類分子的鏈 B MHC類分子的鏈 C MHC類分子的鏈 D MHC類分子的鏈 E C2、C4、TNFC 25 關(guān)于IgG的特性，下列哪項(xiàng)是正確的 A C區(qū)有4個(gè)功能區(qū) B 是胚胎晚期合成的主要抗體 C 是唯一通過胎盤的抗體 D 是天然的血型抗體 E 是分子量最大的抗體B 26 B細(xì)胞具有識別特異性抗原的功能，因其表面有 A E受體 B mIg C sIgA D C3受體 E FC受體C 27 表達(dá)于B細(xì)胞表面的CD40是 A BCR復(fù)合體 B CD19/CD21/CD81/CD225 C 協(xié)同刺激分子 D C3d受體 E BCR識別特異性抗原E 28 發(fā)現(xiàn)免疫球蛋白基因重排規(guī)律的學(xué)者是 A Cantor B Claman C Warner D ChaseE: E TonegawaC 29 根據(jù)移植物來源,哪種腎存活率最高: A 異種腎 B 同種腎 C 同卵雙生同胞供體腎 D 親屬供體腎 E 父母的腎B 30 補(bǔ)體的溶菌作用屬于 A 特異性免疫應(yīng)答 B 非特異性免疫應(yīng)答 C 固有免疫應(yīng)答 D 免疫穩(wěn)定功能 E 適應(yīng)性免疫應(yīng)答A 31 參與補(bǔ)體旁路激活途徑 A B因子 B C4 C 阻止經(jīng)典途徑C3轉(zhuǎn)化酶形成 D 損傷細(xì)胞 E 阻止膜攻擊復(fù)合物的形成C 32 IL-4 A 裂解靶細(xì)胞 B 促進(jìn)T細(xì)胞克隆擴(kuò)增的主要細(xì)胞因子是 C 誘導(dǎo)初始T細(xì)胞分化為TH2 D 表達(dá)于活化T細(xì)胞表面，與活化誘導(dǎo)的細(xì)胞死亡有關(guān) E 與活化M有關(guān)D 33 關(guān)于型干擾素的生物學(xué)活性的敘述應(yīng)除下列哪項(xiàng)? A 激活單核巨噬細(xì)胞 B 抑制病毒的復(fù)制 C 抑制細(xì)胞增生 D 促進(jìn)IL-4的產(chǎn)生 E 促進(jìn)CTL成熟E 34 抗原特異性淋巴細(xì)胞是指 A 只是T淋巴細(xì)胞 B 只是B淋巴細(xì)胞 C NK細(xì)胞 D T淋巴細(xì)胞和NK細(xì)胞 E T淋巴細(xì)胞和B淋巴細(xì)胞D 35 受抗原刺激后，淋巴結(jié)的皮質(zhì)區(qū)見有 A 初級濾泡 B 淋巴索 C 淋巴竇 D 生發(fā)中心 E 冠狀帶B 36 NK細(xì)胞的生物學(xué)作用包括 A 特異性殺傷作用 B ADCC作用 C 免疫復(fù)合物清除作用 D 吞噬靶細(xì)胞 E 誘導(dǎo)急性變態(tài)反應(yīng)的發(fā)生B 37 產(chǎn)生IL-2的細(xì)胞是 A 巨噬細(xì)胞 B T細(xì)胞 C B細(xì)胞 D 肥大細(xì)胞 E NK細(xì)胞B 38 各種Ig單體分子共有的特性是 A 與靶細(xì)胞結(jié)合后能介導(dǎo)ADCC作用 B 具有兩個(gè)完全相同的抗原結(jié)合部位 C 輕鏈與重鏈以非共價(jià)鍵結(jié)合 D 與抗原結(jié)合后能激活補(bǔ)體 E 與顆粒性抗原結(jié)合后能介導(dǎo)調(diào)理吞噬作用C 39 MHC是指 A 不同染色體上編碼組織相容性抗原的基因群 B 同一染色體上編碼次要組織相容性抗原的基因群 C 同一染色體上由一組高度多態(tài)性編碼主要組織相容性抗原的基因群 D 不同染色體上的緊密連鎖的基因群 E 任一染色體上的一組基因群A 40 MHC分子與抗原肽結(jié)合的部位在 A 多態(tài)性區(qū) B 非多態(tài)性區(qū) C 跨膜區(qū) D 胞漿區(qū) E 胞膜外區(qū)B 41 型超敏反應(yīng)是由哪類抗體介導(dǎo)的 A IgG B IgE C IgA D IgD E IgMC 42 接種人痘預(yù)防天花的發(fā)明者是 A 英國人 B 法國人 C 中國人 D 荷蘭人 E 日本人B 43 被活化后可產(chǎn)生介導(dǎo)炎癥反應(yīng)片段的補(bǔ)體成分是 A C1和C2 B C3和C5 C C6和B因子 D C7和C8 E C4和C9E 44 體液免疫，初次免疫應(yīng)答的潛伏期大約為 A 25天 B 36天 C 02天 D 45天 E 710天B 45 B細(xì)胞活化輔助受體包括 A BCR復(fù)合體 B CD19/CD21/CD81/CD225 C 協(xié)同刺激分子 D C3d受體 E BCR識別特異性抗原B 46 關(guān)于IL-4的生物學(xué)功能的敘述，下列哪項(xiàng)應(yīng)除外？ A 誘導(dǎo)B細(xì)胞，發(fā)生免疫球蛋白重鏈的類別轉(zhuǎn)換 B 刺激B細(xì)胞及巨噬細(xì)胞表達(dá)MHC類分子 C Th2細(xì)胞的自分泌生長因子 D 促進(jìn)胸腺細(xì)胞和T細(xì)胞增生 E 肥大細(xì)胞的生長因子D 47 免疫細(xì)胞產(chǎn)生、發(fā)育、分化成熟的場所是 A 淋巴結(jié)和胸腺 B 淋巴結(jié)和骨髓 C 骨髓和脾臟 D 骨髓和胸腺 E 淋巴結(jié)和脾臟D 48 APC上的B7的配體是 A CD2 B CD4 C CD8 D CD28 E CD16E 49 T細(xì)胞主要位于外周淋巴組織中的: A 淋巴小結(jié) B 脾小結(jié) C 脾臟紅髓 D 胸腺皮質(zhì) E 脾臟中央小動(dòng)脈周圍淋巴鞘D 50 傳導(dǎo)B細(xì)胞第一活化信號的分子是 A mIg B 抗原分子 C BCR D Ig/Ig E MHC分子 A 51 人體再次體液免疫應(yīng)答發(fā)生的場所是: A 外周免疫器官 B 淋巴結(jié) C 骨髓 D 胸腺 E 法氏囊C 52 型超敏反應(yīng)中具有重要調(diào)節(jié)作用的細(xì)胞是 A 中性粒細(xì)胞 B 嗜堿性粒細(xì)胞 C 嗜酸性粒細(xì)胞 D 肥大細(xì)胞 E 血小板A 53 非胸腺依賴性抗原的命名是由于 A 它能直接刺激B細(xì)胞產(chǎn)生抗體，無需T細(xì)胞參與 B 抗原來源于非胸腺組織 C 它誘生的抗體在骨髓中產(chǎn)生 D 它誘生的抗體屬于IgA E 它常具有多種復(fù)雜的抗原決定簇A 54 NK細(xì)胞的受體包括 A KAR和KIR B TCR和CR C KAR和BCR D KIR和CR E CDR和KIRA 55 對人體沒有免疫原性的物質(zhì)是： A 自身移植的皮膚 B 異體移植的皮膚 C 自身釋放的晶體蛋白 D 動(dòng)物的免疫血清 E 異種血型的紅細(xì)胞E 56 輔助HIV感染T細(xì)胞的細(xì)胞因子是 A IFN B IL-8 C IL-2 D CD4 E CCR5C 57 型超敏反應(yīng)的啟動(dòng)因素是 A 細(xì)胞因子 B 免疫球蛋白 C 免疫復(fù)合物 D 單核吞噬細(xì)胞 E 淋巴毒素D 58 B細(xì)胞區(qū)別于其他APC的特點(diǎn)是 A 吞噬攝取抗原 B 胞飲攝取抗原 C 通過甘露糖受體攝取甘露糖化抗原 D 通過BCR直接攝取抗原 E 通過FC受體攝取抗原抗體復(fù)合物D 59 參與攻膜復(fù)合物的形成 A B因子 B C4 C C2 D C6 E D因子A 60 免疫缺陷的病人易發(fā)生 A 腫瘤 B 過敏性休克 C 接觸性皮炎 D 自身免疫性溶血性貧血 E 強(qiáng)直勝脊柱炎C 61 關(guān)于Ig正確的敘述是 A 同種紅細(xì)胞凝集素為IgG B 分泌型IgA一般為五聚體 C IgM類抗體合成障礙的患者易發(fā)生菌血癥 D IgM類抗體能通過胎盤 E IgD的Fc段容易同肥大細(xì)胞結(jié)合C 62 IFN-主要由下列哪種細(xì)胞產(chǎn)生? A LAK細(xì)胞 B 巨噬細(xì)胞 C NK細(xì)胞 D 成纖維細(xì)胞 E B淋巴細(xì)胞A 63 病毒持續(xù)感染 A 生理性免疫防御功能低下 B 生理性免疫穩(wěn)定 C 免疫監(jiān)視功能失調(diào) D 免疫穩(wěn)定功能失調(diào) E 免疫防御作用過高B 64 ABO血型抗原屬于 A 自身抗原 B 同種異型抗原 C 超抗原 D 獨(dú)特型抗原 E 異嗜性抗原E 65 關(guān)于抗體，下列哪項(xiàng)描述是不準(zhǔn)確的 A 抗體是指具有免疫功能的球蛋白 B 抗體主要存在于血液、體液、粘膜表面及其分泌液中 C 抗體是能和相應(yīng)抗原特異性結(jié)合的球蛋白 D 抗體都是免疫球蛋白 E 抗體都是體內(nèi)產(chǎn)生的E 66 免疫對機(jī)體 A 是有益的反應(yīng) B 是有害遠(yuǎn)大于有益的反應(yīng) C 是有害的反應(yīng) D 無益也無害的反應(yīng) E 正常條件下對機(jī)體有益，但在一定條件下對機(jī)體有害B 67 HLA類基因區(qū)可編碼的因子是 A IFN B TNF C TGF- D IL-2 E EPOE 68 MHC類分子 A 只存在于紅細(xì)胞上 B 只存在于白細(xì)胞上 C 只存在于淋巴細(xì)胞上 D 只存在于巨噬細(xì)胞上 E 存在于一切有核細(xì)胞上C 69 創(chuàng)建雜交瘤技術(shù)制備單克隆抗體的學(xué)者是 A Koch和Pasteur B Miller和Good C Milstein和Kohler D Tiselius和Kabat E Porter和EdelmanD 70 關(guān)于ADCC的敘述，下列哪項(xiàng)是正確的 A IgM可介導(dǎo)ADCC B M不具有ADCC C CTL可通過ADCC殺傷靶細(xì)胞 D ADCC的殺傷作用是非特異性的 E ADCC需要補(bǔ)體參與B 71 對中性粒細(xì)胞有趨化作用的是 A IFN B IL-8 C IL-2 D L-12 E CCR5C 72 合成分泌片的細(xì)胞是 A B細(xì)胞 B 漿細(xì)胞 C 上皮細(xì)胞 D T細(xì)胞 E 巨噬細(xì)胞A 73 NK細(xì)胞主要存在于 A 血液和淋巴樣組織，特別是脾臟 B 血液和淋巴樣組織，特別是肝臟 C 血液和淋巴樣組織，特別是腎臟 D 血液和淋巴樣組織，特別是肌肉 E 血液和淋巴樣組織，特別是皮下A 74 具有中和作用的血清抗體主要是 A IgG B IgA C IgD D IgE E IgMB 75 促使輔助性T細(xì)胞分化為Th1細(xì)胞的細(xì)胞因子有 A IL-1 B IL-2 C IL-4 D IL-10 E CCR5C 76 關(guān)于HLA類分子的正確敘述是 A 2條多肽鏈均為MHC編碼 B 人類的MHC類分子包括HLA-DR、HLA-DQ、HLA-DP C 主要存在于抗原提呈細(xì)胞的表面，調(diào)控體內(nèi)體液免疫和細(xì)胞免疫應(yīng)答 D 較少分布于各種有核細(xì)胞表面 E HLA類分子由第六染色體短臂上HLA復(fù)合體編碼C 77 B細(xì)胞在抗原刺激及Th細(xì)胞的輔助下，增殖活化為 A 殺傷性細(xì)胞 B 吞噬細(xì)胞 C 漿細(xì)胞 D 輔助性細(xì)胞 E 細(xì)胞毒性細(xì)胞A 78 激活補(bǔ)體能力最強(qiáng) A IgM B IgG C IgE D IgA E IgDA 79 既參與固有性免疫應(yīng)答又參與適應(yīng)性免疫應(yīng)答的成分有 A 巨噬細(xì)胞 B B細(xì)胞 C T細(xì)胞 D 中性粒細(xì)胞 E 漿細(xì)胞D 80 關(guān)于免疫球蛋白正確的敘述是 A IgG的H鏈?zhǔn)擎?B 抗原結(jié)合于Ig的恒定區(qū) C IgA能通過胎盤 D IgE引起型超敏反應(yīng) E IgM的半衰期為23天 1，A decade ago, Nancy did what so many Americans dream about. She quit an executive position and opened/ set up a household device store in her neighborhood. People like Nancy made the decision primarily for the improvement in the quality of their lives. But, to run a small business on a small scale is by no means an easy job. Without her steady income, Nancy had to cut back on her daily expense. Sometimes she did not even have the money to pay the premium for the various kinds of insurance she needed. Fortunately, through her own hard work, she has now got through the most difficult time. She is determined to continue pursuing her vision of a better life. ,2， Shortly after he achieved freedom Henson became intent on assisting fugitive slaves. He secretly returned to the United States from Canada several times to help others to travel the Underground Railroad to freedom. Once some slave catchers closed in on the escaping slaves and Henson when they were on the run. He disguised them and successfully avoided capture. Later he built a small settlement in Dresden in Canada for escaped slaves, setting up a chapel and a school. He held to the conviction that slavery would be abolished, and the day was bound to come when racial discrimination no longer existed. 3，It is almost impossible to keep a determined burglar out. All you can do is discourage him for a few minutes. Thus exposing him to police patrols. Common sense tells us that lighting is a barrier to criminal activity. A light should be fixed in the doorway and switched on at night. Make sure/Assure yourself that you dont leave the door on the latch if you happen to be the last to come in. If you decide to buy a sophisticated electronic alarm system, be sure to ask for its signs and put them up on both windows and doors. In addition you may have it hooked up to a police station 4，What was remarkable about 2005 was perhaps that the UN declared it The World Year of Physics. It was the 100th anniversary of Einsteins theory of relativity and the 50th anniversary of his death. In 1905 Einstein published five highly important essays in the history of science, thus revolutionizing physics. His great achievements can be credited to his impressive powers of imagination, constant questioning, and not giving a fig for authority. It is beyond doubt that Einstein was the greatest scientist in the 20th century. 5，Amid the atmosphere of Thanksgiving, rather than joining his friends in celebration of the holiday, George was immersed in the diary left to him by his father, who died at sea after he completed two successive trips around the world. The diary brought back every moment George had spent with his father and many of the specific things his father did on his behalf. Georges father used to impress on him the need to undergo all kinds of hardship in quest of excellence. He also taught him that nothing in the world could be taken for granted. Even today, George still remembers how his father would quote Aesops famous saying Gratitude is the sign of noble souls and tell him to accord the greatest importance to it. 6，Here and there we see young artists who stand out from other people. They may be in worn-out jeans all the year round, or walk barefoot / in bare feet even in winter, or drink to excess, or cling to the fancy of creating a masterpiece without actually doing any creative work. In fact，many of them act like this just to look the past ，or to be in tune with other artists ，they have forgotten that only thorough persistent effort can one achieve success。 7，Tom was born a cripple, with one of his lower limbs useless. Early in his childhood, he learned that unless he so exerted himself as to rise above his limitations, he could not earn a living, and unless he succeeded in making a living on his own, he could not win/gain the respect of others. That was the price he had to pay for his dignity as a human being. Tom applied for numerous jobs, only to be turned down, before he finally got one as a delivery boy for a Pizza Hut. He then worked as a sales representative for a sportwear company in a territory no one else would want. Today he owns a fairly profitable retail shop in his hometown, and hires several people to work for him ,8，The majority of scientists are adamantly opposed to reproductive cloning and support therapeutic cloning for treating diseases. The reason is that therapeutic cloning does not involve any type of risk to human life and actually provides tremendous potential for the r