異基因造血干細(xì)胞移植治療兒童血液病53034

1、: 112711/(flu/ctx)/(tbi/ctx) 109755 cmv31gvhd 1 abstract objective to investigate the value of allogeneic hematopoietic stem cell transplantation for treatment of children with hematonosis.methods 11 children with hematologic disease were therapied through allogeneic hematopoietic stem cell transpla

2、ntation,including aplastic anemia 2 cases,leukemia 7 cases,myelodysplastic syndrome 1 cases,and non-hodgkins lymphoma 1 cases.the preconditioning were performed with fludarabine/cyclophosphamide or total body irradiation/cyclophosphamide protocols.and to observe the clinical effect of patients.resul

3、ts engraftment was successful in 10 children with hematonosis,9 children were alive and 7 were event free survival,the longest survival time was 55 years;cmv infection were 3 cases,hemorrhagic cystitis was 1 case,secondary diffuse gvhd 1 case.conclusion allogeneic hematopoietic stem cell transplanta

4、tion is an effective methods of treating childhood hematonosis,and is worth being spreaded in clinical practice.key wordshematonosis;children;stem cell;transplantation(hematopoietic stem cells trans-plantationhsct)hscthsct(auto-hsct)hsct(allo-hsct)allo-hscthsct(gvhd)4111 11 116525126,78734211,212 26

5、1213 (flu)/(ctx)(tbi)/(ctx)flu/ctx6flu 3040 mg/(m2d)5 dctx 5060 mg/(m2d)2 dtbi/ctx5ctx ctx 5060 mg/(m2d)2 dtbi 40 gy3 d(12 gy)4(atg)5 mg/(m2d)3 d14 (gvhd)a(csa)+(mtx)1dcsa 8 mg/(kgd)1mtx 15 mg/m2,36mtx 10 mg/m2gvhdcmv10 mg/(kgd)14 d1dcmv-dnae 10 g/d6 h200 ml/(m2h)4 h,24 hctx24 h30004000 ml/(m2d)12 m

6、g/(kg)46 h13 ml/(kgh)ctx125 mg/kg4 h60 mg/(kgd)12 h2 1197(778%)55119gvhd1gvhdcmv32146 d30 d1 3 31 ()(hurlers)20%32 hsctmcglave1(nmdp)142cml(hscs)hsctcmgiac2-3261233 12424gvhd5gvhd6-8gvhdhlagvhdtnkgvhd9gvhda(csa)(mtx)1gvhd;(cmv)cmv9cmvgvhdcmv-dnacmv-dnacmv3(333%)cmvcmv-dna1;97;e11 mcglave pb,shu xo,w

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8、sed ed.pariscentre hayem,2004257-259.4 rocha v,gluckman e.clinical use of umbilical cord blood hematopoietic stem cells.biol blood marrow transplant,2006,12(suppy 1)34-41.5 laughlin mj.umbilical cord blood for allogenic transplantation in children and adults.bone marrow transplant,2001,27(1)1-6.6 ro

9、cha v,cornish j,sievers el,et al.comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia.blood,2001,97(10)2962-2971.7 brahmi z,hommel-berrey g,smith f,et al.nk cells recover early and mediate cytotoxicity via perforin/granzyme and fas/fasl pathways in umbilical cord blood recipients.hum immunol,2001,62(8)82-790.8 goldstein g,toren a,nagler a.human umbilical cord blood biologytransplantation and plasticity.curr med chem,2006,13(11)1249-1259.9 tomonari aiseki tooi jet al.cytomegal