杏芎氯化鈉注射液治療急性腦梗塞32例臨床觀察

1、杏葦氯化鈉注射液治療急性腦梗塞32例臨床觀察【摘要】目的觀察杏時氯化鈉注射液治療急性腦梗塞的臨床療 效。方法將62例急性腦梗塞患者隨機(jī)分成治療組和對照組。兩組常規(guī) 治療方法相同。治療組給予杏時氯化鈉注射液1次/d,靜脈滴注；對 照組加丹奧注射液、克林澳注射液2次/d,靜脈滴注，腦細(xì)胞活化劑 特安欣(肌氨肽昔)注射液1次/d,靜脈滴注，2周后觀察療效。結(jié)果 治療組與對照組的總有效率分別為84. 38%和86. 66%(p>0. 05),顯 效率分別為31.25%、36. 67%(p>0. 05),均無顯著性差異。治療組 在改善神經(jīng)功能缺損方面明顯好于對照組(p&

2、;lt;0. 05)。結(jié)論杏茸氯化 鈉注射液治療急性腦梗塞具有多種治療作用，用藥簡便、療效確切， 而且在改善神經(jīng)功能缺損方面作用較好，值得臨床推廣應(yīng)用?！娟P(guān)鍵詞】杏茸氯化鈉注射液；急性腦梗塞；臨床療效abstract:objectiveto observe the therapeutic effect of floi um gin kgo extract and ter tram ethypyrazine sodi um chloride injection on acute cerebral infarction. methodssixty two cases of patients wit

3、h acute cerebral infarction were divided into two groups at random, treatment group (32 cases) and control group (30 cases)both of the groups were treated with the same ordinary method the cases of the treatment group were given floium ginkgo extract and ter tram ethypyrazine sodium chloride injecti

4、on qd, iv gtt . the cases of the control group were given sodium ozagrel , cinepazide maleate injection ,bid,iv gtt and muscular amino acids and peptides and nucleosides injection to observe the efficacy the treatment course was 2 weeks resuitsthere was no significant difference between two groups t

5、he total effective rate in the treatment group and the control group was 84. 38% and 86.66% respectively (p>0.05) and the excellent effective rate was 31.25% and 36.67% respectively (p>0. 05). the neurological function defect scoring in the treatment group was significantly better than

6、 that of in the control group (p⁢0.05) conclusionbecause floium ginkgo extract and tertram ethypyrazine sodium chloride injection is easily used and has a cocktail positive effect on many kinds of treatment action and improvement of neurological function defect in clinic, it is worth being po

7、pularized and used clinically.key words floium ginkgo extract and tertram ethypyrazine sodium chloride injection, acute cerebral infarction, curative effectcerebral infarction is also called ischemia bra in stroke, a common and frequent cerebrovascular disease in clinic, it is the third leading caus

8、e of death in all kinds of disease in middle-aged population in clinic with high morbidity mortality and disability in recent years acute cerebral infarction is increasing tend to young 1 , at present no single western agent can cure it effectively, but floium ginkgo extract and tertram ethypyrazine

9、 sodium chloride injection can do it. it will expand a new train of thought and open widely field of vision because it contains a variety of molecules with potent biological activities and a cocktai 1 therapeutic method to cure acute cerebral infarction, but the drug hasn，t been used for a long peri

10、od of time, we will observe its efficacy in clinic in order to further investigate therapeutic effect1 clinical materialall the cases were divided randomly into treatment group (32 cases) and control group (30cases) from 62 consecutive acute cerebral infarction patients admitted to our hospita1. dia

11、gnosis of acute cerebral infarction for each case was made according to sta.ndard of cerebral infarction diagnosis and brain computed tomography (ct) and/or magnetic resonanee images (mri) were used to confirm the diagnosis patients with cerebral hemorrhage, liver disfunction, renal disfunction, car

12、diovascular diseases and hematological diseases were excluded.there was no significant difference between two groups in ages, sexes, symptoms, scores of neurological function defect and ord in ary method before the patients admitted to hospital by statistical analysis (p>0.05)1.8 standard of diag

13、nosis diagnosis of acute cerebral infarction was made according to the chinese neurological academy about essentials of diagnosis on each kind of cerebrovascular disease 2 brain computed tomography (ct) and/or magnetic resonance images (mrt) were used to confirm the diagnosistabl comparison of gener

14、al conditions in the two groups(略)clinical symptoms of acute cerebral infarction oftensuddenly trouble standing or walking, speaking or understanding, seeing with one or both eyes and dizziness, loss of balance or coord in ation, numb ness of the face, arm or leg weakness, especially on one side of

15、the body, severe headaches with no known cause, brief loss of consciousness or a period of decreased consciousness (fainting, confusion, convulsi ons or even coma)2 therapeutic methodsthe ordinary method : the cases with hypertension was given anti-hypertension 3 , with hyperglycemia given anti-hype

16、rglycemia, with high lipid given lowing blood lipid, hydrocephalus, and oxygenation, radiotherapy according to the concrete conditions of acute cerebral infarctionthe treatment group was given floium ginkgo extract and ter tram ethypyrazine sodium chloride injection 100250ml, qd, iv gtt the control

17、group was given sodium ozagrel 160mg, cinepazide maleate 160mg injection add to 0. 9%nacl,bid, iv gtt and muscular amino acids and peptides and nucleosides 10ml tnjection qd, iv gtt the treatment course was 2 weeksstatistical analyses were made using the target of neurological function defect scorni

18、ng and clinical symptom, for x2 test, differences with a value of p< 0.05 were considered significant all the data were treated by spss11.5.criterion standard of efficacy:al 1 the cases were judged effect using nimoldipine method after treated 2wk, based on 1993 ministry of heath p. r. china,

19、 guidence of principle of clinical research of new drug of chinese traditional medicine on stroke by scoring to observe the comprehensive function of patients consciousness, language, 1imbs 4 each of score is 04, the full is 28, the function defect scoring decreased more than 85% is basically cure,

20、50% is apparent effect, 20% is ameliorate, less than 20% or deteriorating to death is no effect or changetab2 the treatment result （略）the excellent rate, x2 = 0. 203 , p > 0. 05. the total effective rate, x2 = 0. 066, p>005, there was no significant difference by spss x2 test, but 1 patient wa

21、s dead in treatment group mortality 3. 13%； 2 patients were dead in control group mortality 6. 67%.tab3 neurological function defect scoring (略)the neurological function defect scores after therapy decreased more apparently than those that before therapy both between therapy and control groups throu

22、gh statistical treatment t test with remarkable difference (p⁢0.05).discussion chinese medical philosophy thinks that acute cerebral infarction caused by wind-pglegm static blood and impediment of vital energy stagnating at main channel, qi vacuity blood stasis, both qi and blood are absent,

23、organ function is out of contro 1. it is characterized by its emphasis on maintaining and restoring homeostasis through interaction with a wide variety of targets so chinese traditional medicine and materia medica expresse its special advantage and play important roles on the treatment and preventio

24、n. floium ginkgo extract and tertram ethypyrazine sodium chloride injection contains a variety of molecules with potent biological activities and many action such as anti-thrombosi s, thrombolysis, dilatation of brain vessels and increasing of its blood f1ow, improvement of hematology, microcirculat

25、ion, immunity cerebrovascular infarction and scavenging free radical, prevention of acute brain injury, restoration of injured nerve, inhibition of platelet aggregation, anti-inflammation reaction and increase of the tolerance to anoxia and anti-fatigue, promotion of cardi o-cerebral celluar metabol

26、ism, enhanci ng memory, and relieving the sequel for apop lex y. the levels of tnf- a , et1 significantly decreased and no were remarkably higher in patients with cerebral infarction when it was used alone5.ozagrel, a selective remarkable effective thromboxane a2 (txa2) synthetase inhibitor 6 , anti

27、thrombotics, prevents the formation of blood clots by preventing the accumulation of platelets that form the basis of blood clots: cinepazide maleate a calcium channel antagoni sts, di late brain blood vessel, improve microcirculation to increase its blood flow, muscular amino acids and peptides and

28、 nucleosides an important material to take part in life activity of human body.floium ginkgo extract and tertram ethypyrazine sodium chloride injection itself has a cocktail therapeutic effect and is used conveniently so it should be payed enough attention by physician for its advantage on improvement of neurological function defect with a cocktail therapeutic effect even though the total effective rate and the remarkable effect rate has no significant differen