遺傳學(xué)測試題：10-免疫與藥物

1、Hao l 1. 自身免疫性疾病所不具備的特性是（）。(7.0分)A.血清中存在自身抗體B.常呈慢性發(fā)作C.單基因顯性遺傳D.多發(fā)于女性E.激素治療有一定療效2. 與強(qiáng)直性脊椎炎相關(guān)聯(lián)的HLA分子是（）。(7.0分)A.B27B.DQ2C.B35D.DR3E.CW63. HLA復(fù)合體不具有的特點是（）。(7.0分)A.交換頻率最高的區(qū)域B.免疫功能相關(guān)基因最集中的區(qū)域C.最富有多態(tài)性的1個區(qū)域D.人類基因組中密度最高的區(qū)域E.與疾病關(guān)聯(lián)最為密切的一個區(qū)域4. 父子之間HLA完全相同的可能性是（）。(7.0分)A.0.75B.0.25C.1/2D.0E.25. 同胞之間HLA完全相同的可能性是（

2、）。(7.0分)A.0.75B.0.25C.1/2D.0E.16. 在同一染色體上HLA各座位等位基因因緊密連鎖，完整傳遞，這種組成稱為（）。(7.0分)A.單一型B.單倍型C.單體型D.單倍體E.單位點7. HLA-L、HLA-H、HLA-J和HLA-X這些基因均因突變而無表達(dá)產(chǎn)物，他們被稱為（）。(7.0分)A.補(bǔ)體基因B.非經(jīng)典基因C.MIC基因D.假基因E.腫瘤壞死因子基因8. Rh溶血病很少發(fā)生于第1胎的原因是（）。(7.0分)A.胎兒組織能夠吸收母體的抗體B.母體初次致敏，未能產(chǎn)生足量的抗體C.母體具有足量的抗體，但不能進(jìn)入胎兒內(nèi)D.Rh陽性的胎兒血細(xì)胞不能進(jìn)入母體E.以上都不是9

3、. Variation in the activity of the cytochrome P450 family of proteins most directly affects which of the following?(7.0分)A.Drug metabolismB.Amount of drug taken up into cellsC.Amount of drug taken up by the bodyD.Excretion of drug metabolites by the kidney10. Which of the following is not involved i

4、n generating antibody diversity?(7.0分)A.a high rate of somatic mutationB.junctional diversityC.somatic recombinationD.a high rate of germline mutationE.multiple copies of V, J, and D genes in the germline11. Autoimmune diseases (7.0分)A.A and CB.are sometimes associated with specific MHC class I alle

5、lesC.may sometimes involve molecular mimicryD.are sometimes associated with specific MHC class II allelesE.A, B, and C12. A likely explanation for autoimmune disease is (7.0分)A.Lack of a memory B cell responseB.Depletion of T cell activity as a result of interleukin deficiencyC.Depletion of B cell a

6、ctivity as a result of interleukin deficiencyD.Repeated infection by the same microbe eventually stimulates an autoimmune responseE.Mimicry of self proteins by a foreign pathogen13. Why is there so much MHC (major histocompatibility locus) allelic diversity among individuals in populations? (8.0分)A.

7、There are hundreds of different MHC loci, and they are shuffled by somatic recombinationB.The MHC region has a high level of somatic hypermutationC.Diversity enables the population to combat a larger number of different pathogensD.This region is especially susceptible to the effects of genetic drift

8、E.MHC diversity ensures that most tissue grafts will be rejected14. Which of the following is a major difference in the mechanisms for generating diversity in T cell receptors and B cell immunoglobulins (antibodies)?(8.0分)A.Junctional diversity is generated only in T cell receptor genesB.There are multiple variable region genes for immunoglobulins but not for T cell receptorsC.Somatic recombination is seen only in immunoglobulin genesD. Somatic hypermut