中科院深圳先進技術(shù)科學院接受客座學生專業(yè)

1、精選文檔中國科學院深圳先進技術(shù)爭辯院導師簡況表導師姓名萬曉春性別男職稱爭辯員專業(yè)名稱免疫學導師類別博導 碩導所在單元醫(yī)藥所抗體藥物爭辯中心是否兼職是 否招生專業(yè)物理化學（含化學物理）生物化學與分子生物學信號與信息處理模式識別與智能系統(tǒng)計算機應用技術(shù)材料工程電子與通信工程把握工程計算機技術(shù)生物工程爭辯方向抗體藥物研發(fā)免疫細胞信號傳導炎癥/自身免疫性疾病及癌癥的治療在研課題無。個人簡歷萬曉春爭辯員畢業(yè)于加拿大蒙特利爾高校醫(yī)學院，在世界首次成功研制抗EPHRIN家族成員的單抗和多抗試劑，引起多家公司的關(guān)注，并在類風濕關(guān)節(jié)炎、肝炎等多種疾病模型試驗中有重大發(fā)覺，獲得加拿大國家健康爭辯院（CIHR）優(yōu)秀

2、爭辯員獎。萬曉春爭辯員具有多年在GLP試驗室條件下臨床及臨床前的爭辯經(jīng)受，具有在CRO GLP試驗室進行抗體和臨床樣品分析，免疫學方法研發(fā)和驗證的閱歷，對抗體藥物的PD/ PK藥物檢測和臨床藥物分析具有豐富的閱歷。萬曉春爭辯員近些年來分別在賓夕法尼亞高校、Eisai、Merck及 Frontagelab等美國一流的科研與大型制藥公司以高級爭辯員從事單抗藥物的研發(fā)工作，曾與美國大型生物制藥公司 HUMAN GENOME SCIENCE公司合作爭辯DcR3基因在免疫系統(tǒng)中的作用，首次在世界上成功研制DcR3 的廣譜癌癥檢測系統(tǒng)（ELISA 試劑盒），在癌癥檢測及監(jiān)測上有重大意義。主要科研成果及所獲

3、榮譽1. Wan X, Shi G, Semenuk M, Zhang J, and Wu J. DcR3/TR6 modulates immune cell interactions. J Cell Biochem. 2003 Jun 1; 89(3): 603-122. Wan X*, Zhang J*, Luo H, Shi G, Kapnik E, Kim S, Kanakaraj P and Wu J. A TNF family member LIGHT transduces costimulatory signals into human T cells. J Immunol. 2

4、002 Dec 15;169 (12):6813-21(*equal contribution)3. Shi G, H Luo, Wan X, J Zhang and Wu J. Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood. 2002 Nov 1;100 (9):3279-864. Wan X*, Zhang J*, Salcedo TW*, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, M

5、oore PA, and Wu J. Modulation of T-cell responses to alloantigens by TR6/DcR3. J Clin. Invest. 2001 Jun;107(11):1459-68 (*equal contributors)5. Luo H, Wan X, Wu Y, and Wu J. Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. J Immunol 2001 Aug 1;167(3):1362-706. L

6、uo H, Wu Y, Qi S, Wan X, Chen H, and Wu J. A proteasome inhibitor effectively prevents mouse heart allograft rejection. Transplantation 2001 Jul 27;72(2):196-2027. Chen H, Xu D, Luo H, Loubeau M, Wan X, Peng J, Qi S, Daloze P, Fritzsimmons W E, Bersky I, Peets J, Sehgal S N, and Wu J. Compromised re

7、nal graft rejection response in Vervet monkeys after withdrawal of immunosuppressants Prograf and Sirolimus. Transplantation 69:1555-1561, 2000其他2004-2007 加拿大健康爭辯院優(yōu)秀爭辯員獎2005 臨床免疫學會聯(lián)合會會議摘要和旅行獎聯(lián)系方式郵箱xc.wan電人主頁備注NameXiaochun WanPositionsexecutive director of the centreAcademic titleprofess

8、orE-mailxc.wanPhonersonal WebsiteResume Dr. Wan was graduated from the medical school of University of Montreal. He is the first scientist in the world who was succeeded in developing the anti-EPHRIN monoclonal antibodies and polyclonal antibodies. He also made some important discoverie

9、s in a variety of disease models such as rheumatoid arthritis and hepatitis and won the scholar award of Canadian Institute of Health Research (CIHR). He has many years of experience on the research and development of therapeutic antibody drugs and investigation of autoimmune diseases. Dr Wan has mo

10、re than six years of GLP research experience in clinical and preclinical laboratories and experience of antibody and clinical samples analysis in CRO GLP laboratory. He is also an expert on PD/PK antibody drugs and clinical drug analysis. Dr Wan had been working in the University of Pennsylvania, se

11、veral well-known pharmaceutical companies such as Eisai, Merck, Frontagelab in the past years. He had been working with HUMAN GENOME SCIENCE biopharmaceutical corporation in studying the role of DcR3 in immune system. He was the first investigator in developing a DcR3 ELISA kit (a broad spectrum of

12、cancer detection system) that has great significance in cancer detection and surveillance.DirectionTherapeutic antibody developmentimmune cell signalingAutoimmune/inflammation and cancer therapyAchievements2004-2007 Canadian Institute of Health Research (CIHR) Scholar Award2005Abstract and travel aw

13、ard, Federation of clinical immunologist Societies (FOCIS) ConferenceArticle1. Wan X, Shi G, Semenuk M, Zhang J, and Wu J. DcR3/TR6 modulates immune cell interactions. J Cell Biochem. 2003 Jun 1; 89(3): 603-122. Wan X*, Zhang J*, Luo H, Shi G, Kapnik E, Kim S, Kanakaraj P and Wu J. A TNF family memb

14、er LIGHT transduces costimulatory signals into human T cells. J Immunol. 2002 Dec 15;169 (12):6813-21(*equal contribution)3. Shi G, H Luo, Wan X, J Zhang and Wu J. Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood. 2002 Nov 1;100 (9):3279-864. Wan X*, Zhang J*, Salce

15、do TW*, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, Moore PA, and Wu J. Modulation of T-cell responses to alloantigens by TR6/DcR3. J Clin. Invest. 2001 Jun;107(11):1459-68 (*equal contributors)5. Luo H, Wan X, Wu Y, and Wu J. Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. J Immunol 2001 Aug 1;167(3):1362-706. Luo H, Wu Y, Qi S, Wan X, Chen H, and Wu J. A proteasome inhibitor effectively prevents mouse heart allograft rejection. Transplantation 2001 Jul 27;72(2):196-2027. Chen H, Xu D, Luo H, Loubeau M