青年酗酒者對(duì)酒精相關(guān)線索的早期注意調(diào)節(jié)：一個(gè)ERP研究ppt課件

1、Early attentional modulation by alcohol-related cues in young binge drinkers: An event-related potentials study青年酗酒者對(duì)酒精相關(guān)線索的早期留意調(diào)理：一個(gè)ERP研討Clinical Neurophysiology臨床神經(jīng)生理學(xué)I F: 2.979 Graldine Petit.一、問(wèn)題提出 1、Binge drinking refers to the consumption of a large number of drinks over a short interval of ti

2、me followed by periods of abstinence. Binge drinking is a common occurrence among younger people, especially university students酗酒指在禁欲后短時(shí)間里消費(fèi)大量的酒精。酗酒的通常是年輕人，特別是大學(xué)生。定義、對(duì)象.2、 The effects of alcohol on the central nervous system (CNS) have been extensively studied, and the neurocognitive, neuroanatomic

3、al and neurofunctional consequences of chronic alcohol abuse in alcohol-dependent adults have been documented (Oscar-Berman and Marinkovic2007).大量的 的研討曾經(jīng)證明酒精會(huì)影響中樞神經(jīng)系統(tǒng)(CNS) 。成人酒精依賴者長(zhǎng)期的酒精亂用對(duì)其神經(jīng)認(rèn)知，神經(jīng)解剖和神經(jīng)功能產(chǎn)生的影響(Oscar-Berman and Marinkovic2007)。影響.3、Compared with adults, relatively little is known abou

4、t adolescent binge drinking and its neurocognitive consequences。 A few recent studies have explored the cerebral consequences of binge drinking in nonclinical samples of adolescents and university students.相比成人，相對(duì)很少知道青少年酗酒者對(duì)他們的神經(jīng)認(rèn)知影響情況。最近很少有研討探求了酗酒對(duì)非臨床青少年樣本和大學(xué)生的大腦影響。問(wèn)題.4、With respect to the neurocog

5、nitive effects of binge drinking in youths, it is important to evaluate similarities with deficits induced by long-term alcohol consumption in adults so as to be able to develop adapted information and prevention programs for young people.關(guān)于酗酒會(huì)對(duì)青少年神經(jīng)認(rèn)知影響，那么有必要的去評(píng)價(jià)成人長(zhǎng)期酒精消費(fèi)導(dǎo)致的缺陷，這樣可以獲取有效的信息和的開展對(duì)青少年人群預(yù)

6、防工程.5、The aim of the present study was to investigate whether binge drinking students, with their brief history of alcohol exposure compared to adults, and without a diagnosis of AUD, exhibit any modulation in alcohol-cue processing. More specifically, we wanted to examine whether there was any diff

7、erence in cerebral reactivity between students with binge drinking habits and paired controls when they were confronted by alcohol-related compared to nonalcohol- related (control) cues.當(dāng)前研討的目的在于去調(diào)查相比成人，短期的酒精暴露歷史、酗酒的學(xué)生和沒(méi)有診斷出AUD的人，能否展現(xiàn)出對(duì)任何酒精線索加工調(diào)理。更特別是，我們想調(diào)查對(duì)于非酒精-酒精相關(guān)線索對(duì)于酗酒的學(xué)生和配對(duì)控制組相比的大腦反響能否存在差別。.6、O

8、ur main hypothesis was that binge drinkers (as compared to controls) will display an enhanced attentional processing of alcohol-related stimuli as compared to unrelated alcohol ones.我們主要的研討假設(shè)就是酗酒者會(huì)顯示出相比非酒精相關(guān)線索添加對(duì)酒精相關(guān)的留意加工。.二、研討方法一被試We first conducted a general screening phase among students at the F

9、aculty of Psychology of Brussels (Belgium) University. Three hundred students completed a questionnaire that assessed psychological measures as well as alcohol and drug consumption characteristic我們首先實(shí)施的是對(duì)the Faculty of Psychology of Brussels (Belgium) University普通的刷選。300個(gè)學(xué)生完故意理丈量和酒精和藥物消費(fèi)特征評(píng)價(jià)。.select

10、ion criteria: no major medical problems, no historyof CNS disease (including epilepsy and history of brain trauma), no visual impairment, no past or current drug consumption (other than alcohol), no family history of alcoholism, very low alcohol consumption and absence of binge drinking habits befor

11、e starting university studies but maintenance of the same drinking pattern since then.選擇規(guī)范：無(wú)主要的醫(yī)療問(wèn)題，沒(méi)有中樞神經(jīng)系統(tǒng)疾病包括，癲癇腦部創(chuàng)傷，沒(méi)有視覺(jué)損傷，過(guò)去和當(dāng)前沒(méi)有藥物運(yùn)用酒精以外，沒(méi)有酒精成癮家族史，在上大學(xué)學(xué)習(xí)前酒精低消費(fèi)和沒(méi)有酗酒習(xí)慣而且不斷維持一樣的方式到如今。為什么都有這些刷選規(guī)范？.All participants were assessed for several psychological measures: State and Trait Anxiety (STAI A a

12、nd B, Spielberger et al., 1983), depression (BDI, Beck and Steer, 1987) and alexithymia (TAS 20, Bagby et al., 1994).一切的被試要經(jīng)過(guò)幾個(gè)心思檢驗(yàn)進(jìn)展評(píng)價(jià)：形狀特質(zhì)焦慮問(wèn)卷(STAI A and B, Spielberger et al., 1983)，抑郁量表(BDI, Beck and Steer, 1987)，述情妨礙(TAS 20, Bagby et al., 1994).On this basis, 36 students were selected. Accordin

13、g to their alcohol consumption characteristics while at university, students were divided into two groups, each of 18 participants: controls and binge drinkers.基于上面的刷選規(guī)范，共選出了36名被試。根據(jù)他們?cè)诖髮W(xué)學(xué)習(xí)時(shí)的的酒精消費(fèi)特征分為兩組，每組18名被試：控制組和酗酒組.Participants were provided with full details regarding the aims of the study and

14、the procedure to be followed and gave their informed consent after receiving this information. The local ethical committee of Brugmann Hospital approved the study. All the participants were between the ages of 19 and 26, with normal/corrected vision, normal hearing, no medication and no history of n

15、eurological disease. We matched the groups for age, sex 。本研討向被試提供全部的詳細(xì)的關(guān)于研討的目的和過(guò)程，在被試知道研討信息后，獲取知情贊同。同樣此研討獲得Brugmann Hospital 倫理委員會(huì)的支持。一切被試的年齡在19-26歲，有正常/矯正視力，正常聽(tīng)覺(jué)才干，沒(méi)有醫(yī)療和沒(méi)有神經(jīng)相關(guān)的疾病。同時(shí)，我們將兩組在年齡，性別進(jìn)展匹配.The groups characteristics are shown in Table 1.二、視覺(jué)資料的預(yù)備Alcohol-related pictures and non-alcohol-rel

16、ated (control) pictures were used as target deviant stimuli placed among frequent neutral stimuli ，Moreover, all these deviant stimuli (alcohol and control) presented a neutral, negative or positive scene. To construct this set of picture stimuli, we started with 44 pictures, chosen from the Interna

17、tional Affective Picture System (IAPS) (Lang et al., 1997), or from our own selection on the internet.酒精相關(guān)圖片和酒精不相關(guān)圖片 control 在一定頻率中性刺激中作為目的偏向刺激。一切這些偏向刺激分為中性，消極或者積極場(chǎng)景。我了構(gòu)造這些刺激，我們從國(guó)際心情圖片庫(kù)(IAPS)和互聯(lián)網(wǎng)上共 選了44張圖片。.中性心情酒精圖片中性心情非酒精圖片消極心情酒精圖片.積極心情中性圖片積極心情酒精圖片消極心情中性圖片.CACNPN320個(gè)刺激CN中性控制刺激72%4個(gè)blockPANANN目的刺激每個(gè)

18、5次，占28%800毫秒600 and 1000 ms間隔1200ms的反響時(shí)間正確率和反響時(shí)三程序visual oddball paradigm.四EEI記錄和分析1、32導(dǎo)2、10-20電極3、增益300004、帶通0.01100 Hz.5、電阻below 56、基線200，持時(shí)間800ms7、低通濾波：30 Hz8、(90160 ms for P100；200300 ms for N2b；350650 ms for P3b.These values were tested using repeated measures of analysis of variance (ANOVA Gre

19、enhouse Geisser correction was applied when appropriate), paired sample t-tests and two-tailed Pearson correlations反復(fù)丈量方差分析，配對(duì)樣本t檢驗(yàn)，雙側(cè)Pearson相關(guān).三、結(jié)果呈現(xiàn)一、 Behavioural data行為數(shù)據(jù)Overall, behavioural data showed that independently of their group, participants detected the deviant， Positive stimuli faster

20、than the neutral ones, and that in the neutral emotional context, reaction times were faster for alcohol- than for non-alcohol-related stimuli?？傮w上，行為數(shù)聽(tīng)闡明，組間沒(méi)有差別，被試間發(fā)現(xiàn)了差別，積極的刺激比中性的快。在中性心情背景下， 酒精比非酒精相關(guān)刺激反響時(shí)間快。.二刺激評(píng)價(jià)No significant effect of group was found, but atype * group interaction was observedwhi

21、ch suggests that independently of the stimuli valence, controls subjects evaluated non-alcohol related pictures as more positive than alcohol-related ones 。whereas there was no significantdifference between the two stimulus types in the binge drinkers group組間沒(méi)差別，刺激類型和組間存在交互作用闡明，控制組評(píng)價(jià)非酒精圖片比酒精相關(guān)圖片更積極。

22、在酒精組兩類刺激類型沒(méi)有差別。.三ERP data1、Latencies There was no significant effect of group or of group * stimulus type interaction for any ERP components latencies, which is congruent with the absence of group differences for behavioural data (p .05). 組間或者組*刺激類型之間對(duì)于任何latencies的ERP成分都沒(méi)有顯著影響，和行為數(shù)據(jù)沒(méi)有組間差別是一致的。.2、Amp

23、litudes波幅P100 ：.N2b無(wú)差別P3b無(wú)差別.4、相關(guān) The results showed that the longer the duration of binge drinking habits, the larger the P100 amplitude to alcohol- related cues (r = .666; p = .003), and the greater the number of doses consumed per week, the larger the P100 amplitude to alcohol-related cues (r = .

24、491; p = .039). 結(jié)果闡明，酗酒習(xí)慣時(shí)間更長(zhǎng)，對(duì)酒精相關(guān)線索時(shí) P100波幅更大，每周用量越大對(duì)酒精相關(guān)線索時(shí) P100波幅更大.四、討論一The differences between binge drinkers and control participants specifically involved the P100 component. P100 amplitudes elicited by alcohol-related pictures were significantly larger than those elicited by neutral picture

25、s in individuals with binge drinking habits, whereas there were no significant differences in the P100 amplitudes of controls with the different stimuli. 酗酒者和控制組的差別涉及到P100成分。酗酒者對(duì)酒精相關(guān)圖片相比中性圖片誘發(fā)更大的P100。而控制組沒(méi)有發(fā)現(xiàn)這個(gè)景象。.二 It is important to note that, even though such an increase in the P100 component was not observed in the control group, the results showed that, at