NO-Synthase-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html NO HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html SynthaseNitric oxide synthases; NOSNitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide

2、(NO) from L-arginine. NO synthasescatalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducibleNOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range ofphysiologic functions i

3、n the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologicconditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOSinhibitors has great potential for therapeutic treatments of NO-related disease

4、s.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html NO HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html Synthase HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html HYPERLINK https:/www.MedChemE/Targets/NO Synthase.h

5、tml Inhibitors, HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html Agonists, HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html Antagonists HYPERLINK https:/www.MedChemE/Targets/NO S

6、ynthase.html HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html & HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html HYPERLINK https:/www.MedChemE/Targets/NO Synthase.html Activators HYPERLINK https:/www.MedChemE/plus-14-deoxy-caesalpin.html (+)-14-Deoxy-caesalpin(14-Deoxy-caesalpin) Cat. No

7、.: HY-N1494 HYPERLINK https:/www.MedChemE/6e-1-7-bis-4-hydroxyphenyl-6-hepten-3-one.html (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-oneCat. No.: HY-N0997(+)-14-Deoxy-caesalpin (14-Deoxy-caesalpin), acassane diterpenoid, inhibits nitric oxide (NO)production release of RAW 264.7 cells stimulatedby Lipop

8、olysaccharide (LPS).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one(compound7) is a nature product isolated fromrhizomes of Curcuma kwangsiensis.(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one hasinhibitory effect on NO production induced by

9、 LPSin macrophages with an IC value of 8.93 M.50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/rac-mri-1867.html (Rac)-Zevaquenabant(Rac)-MRI-1867) Cat. No.: HY-141411 HYPERLINK https:/www.MedChemE/1400W_Dihydrochloride.html 1400W HYPERLINK https:/www

10、.MedChemE/1400W_Dihydrochloride.html HYPERLINK https:/www.MedChemE/1400W_Dihydrochloride.html DihydrochlorideCat. No.: HY-18731(Rac)-Zevaquenabant (Rac)-MRI-1867, compound 6b)is a cannabinoid receptor type 1 (CB R)/iNOS1antagonist, with a K of 5.7 nM for CB R.i 1(Rac)-Zevaquenabant is potential for

11、the researchof liver fibrosis.1400W dihydrochloride is a potent and selectiveinhibitor of human inducible NO synthase with Kvalues of 7 nM.iPurity: 99.05%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 99.65%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 5

12、0 mg, 100 mg HYPERLINK https:/www.MedChemE/2-4-diamino-6-hydroxypyrimidine.html 2,4-Diamino-6-hydroxypyrimidine HYPERLINK https:/www.MedChemE/2-4-diamino-6-hydroxypyrimidine.html HYPERLINK https:/www.MedChemE/2-aminoquinoline.html 2-AminoquinolineCat. No.: HY-100954 Cat. No.: HY-W0075242,4-Diamino-6

13、-hydroxypyrimidine is a specific GTPcyclohydrolase I inhibitor (the rate-limitingenzyme in de novo pterin synthesis).2,4-Diamino-6-hydroxypyrimidine blocksTetrahydrobiopterin (BH4) synthesis and suppressesNO production.2-Aminoquinoline is a promising compound asbioavailable nNOS inhibitor but suffer

14、s from lowhuman nNOS inhibition, low selectivity versushuman eNOS, and significant binding to other CNStargets. 2-Aminoquinoline has the potential forthe research of antineurodegenerative agents.Purity: 99.97%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mgPurity: 98%Clinical Data: No

15、Development ReportedSize: 500 mg HYPERLINK https:/www.MedChemE/2-iminobiotin.html 2-Iminobiotin HYPERLINK https:/www.MedChemE/2-iminobiotin.html HYPERLINK https:/www.MedChemE/2-iminobiotin-hydrobromide.html 2-Iminobiotin HYPERLINK https:/www.MedChemE/2-iminobiotin-hydrobromide.html HYPERLINK https:/

16、www.MedChemE/2-iminobiotin-hydrobromide.html hydrobromide(Guanidinobiotin) Cat. No.: HY-118700 (Guanidinobiotin hydrobromide) Cat. No.: HY-118700A2-Iminobiotin (Guanidinobiotin) is a biotin(vitamin H or B7) analog. 2-Iminobiotin is areversible nitric oxide synthases inhibitor withKi iNOSs of 21.8 an

17、d 37.5M for murine and ratn-cNOS, respectively.2-Iminobiotin hydrobromide (Guanidinobiotinhydrobromide) is a biotin (vitamin H or B7)analog. 2-Iminobiotin hydrobromide is a reversiblenitric oxide synthases inhibitor with Ks of 21.8iand 37.5 M for murine iNOS and rat n-cNOS,respectively.Purity: 98.0%

18、Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg HYPERLINK https:/www.MedChemE/2-thiouracil.html 2-Thiouracil HYPERLINK https:/www.MedChemE/2-thiouracil.html HYPERLINK https:/www.MedChemE/3_acute_,4_acute_-Dihydroxyflavonol

19、.html 3,4-Dihydroxyflavonol(Thiouracil) Cat. No.: HY-B0503 (DiOHF) Cat. No.: HY-1118042-Thiouracil (Thiouracil) is an antithyroidcompound. 2-Thiouracil can function as a highlyspecific melanoma seeker. 2-Thiouracil is aselective inhibitor of neuronal nitric oxidesynthase (nNOS) with a K of 20 M.i3,4

20、-Dihydroxyflavonol (DiOHF) is an effectiveantioxidant, which reduces superoxide and improvesnitric oxide (NO) function in diabetic ratmesenteric arteries.Purity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2 Tel:

21、 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/3-bromo-7-nitroindazole.html 3-Bromo-7-nitroindazole HYPERLINK https:/www.MedChemE/3-bromo-7-nitroindazole.html HYPERLINK https:/www.MedChemE/3-o-acetyl-16-hydroxydehydrotrametenolic-acid.html 3-O-Acetyl-16-hydroxydeh

22、ydrotrametenolic HYPERLINK https:/www.MedChemE/3-o-acetyl-16-hydroxydehydrotrametenolic-acid.html HYPERLINK https:/www.MedChemE/3-o-acetyl-16-hydroxydehydrotrametenolic-acid.html acidCat. No.: HY-101175 Cat. No.: HY-N29893-Bromo-7-nitroindazole is a more potent andselective inhibitor of neuronal nit

23、ric oxidesynthase (nNOS) than eNOS or inducible nitricoxide synthase (iNOS). 3-Bromo-7-nitroindazoleaffects the intercellular messenger nitric oxide(NO) synthesis throughout the body and brain.3-O-Acetyl-16-hydroxydehydrotrametenolic acid, ananti-inflammatory triterpenoid, inhibits NOproduction and

24、iNOS expression in LPS-stimulatedRaw264.7 cells.Purity: 98.12%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/6-Biopterin.html 6-Biopterin(L-Biopterin) Cat. No.: HY-102

25、015 HYPERLINK https:/www.MedChemE/7-8-dihydroneopterin.html 7,8-DihydroneopterinCat. No.: HY-1363416-Biopterin (L-Biopterin), a pterin derivative, isa NO synthase cofactor.7,8-Dihydroneopterin, an inflammation marker,induces cellular apoptosis in astrocytes andneurons via enhancement of nitric oxide

26、 synthase(iNOS) expression. 7,8-Dihydroneopterin can be usedin the research of neurodegenerative diseases.Purity: 99.89%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg HYPERLINK https:/www.Med

27、ChemE/7-ethoxyresorufin.html 7-Ethoxyresorufin(Resorufin ethyl ether) Cat. No.: HY-D0145 HYPERLINK https:/www.MedChemE/7-ethoxyresorufin-d5.html 7-Ethoxyresorufin-d5(Resorufin ethyl ether-d5) Cat. No.: HY-D0145S7-Ethoxyresorufin (Resorufin ethyl ether) is afluorometric substrate and competitive inhi

28、bitorof cytochrome P450, especially CYP1A1.7-Ethoxyresorufin also inhibits NO synthase.7-Ethoxyresorufin-d5 is deuterium labeled7-Ethoxyresorufin. 7-Ethoxyresorufin (Resorufinethyl ether) is a fluorometric substrate andcompetitive inhibitor of cytochrome P450,especially CYP1A1. 7-Ethoxyresorufin als

29、o inhibitsNO synthase.Purity: 98.83%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/7-nitroindazole.html 7-Nitroindazole HYPERLINK https:/www.MedChemE/7-nitroindaz

30、ole.html HYPERLINK https:/www.MedChemE/8a8.html 8A8Cat. No.: HY-69019 Cat. No.: HY-1159277-Nitroindazole is a selective nNOS inhibitorwith antinociceptive and cardiovascular effects.7-Nitroindazole is a useful tool to evaluate thebiological roles of nitric oxide in the centralnervous system.8A8 is a

31、 potent proinflammatory factor NOinhibitor with an IC of 4.7 M. 8A8 also50significantly inhibits LPS-induced HaCat cellproliferation.Purity: 98.97%Clinical Data: No Development ReportedSize: 500 mg, 1 gPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/ab

32、ai-30.html ABAI-30 HYPERLINK https:/www.MedChemE/abai-30.html HYPERLINK https:/www.MedChemE/Agmatine_sulfate.html Agmatine HYPERLINK https:/www.MedChemE/Agmatine_sulfate.html HYPERLINK https:/www.MedChemE/Agmatine_sulfate.html sulfateCat. No.: HY-115931 Cat. No.: HY-101238ABAI-30 is a potent and ora

33、lly activeanti-inflammatory agent. ABAI-30 effectivelyinhibits NO production in lipopolysaccharide (LPS)induced RAW264.7 cells.Agmatine sulfate exerts modulatory action atmultiple molecular targets, such asneurotransmitter systems, ion channels and nitricoxide synthesis. It is an endogenous agonist

34、atimidazoline receptor and a NO synthaseinhibitor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg, 500 mg, 1 gwww.MedChemE 3 HYPERLINK https:/www.MedChemE/amaroswerin.html AmaroswerinCat. No.: HY-N9337 HYPER

35、LINK https:/www.MedChemE/Aminoguanidine-hydrochloride.html Aminoguanidine HYPERLINK https:/www.MedChemE/Aminoguanidine-hydrochloride.html HYPERLINK https:/www.MedChemE/Aminoguanidine-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/Aminoguanidine-hydrochloride.html (Pimagedine hydrochl

36、oride;GER-11; Aminoguanidinium chloride) Cat. No.: HY-B1041Amaroswerin is a bioactive secoiridoid glucosidefrom Swertia mussotii. Amaroswerin hasanti-inflammatory, antidiabetic, antiviral,anticholinergic and immunomodulatory activities.Aminoguanidine hydrochloride is a diamine oxidaseand NO synthase

37、 inhibitor, reduces levels ofadvanced glycation end products (AGEs) throughinteracting with 3-deoxyglucosone, is aninvestigational drug for the treatment of diabeticnephropathy.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 98.0%Clinical Data: Phase 1Size: 10 mM 1 m

38、L, 100 mg HYPERLINK https:/www.MedChemE/aminopicoline.html Aminopicoline(Ascensil) Cat. No.: HY-W003969 HYPERLINK https:/www.MedChemE/amt-hydrochloride.html AMT HYPERLINK https:/www.MedChemE/amt-hydrochloride.html HYPERLINK https:/www.MedChemE/amt-hydrochloride.html hydrochlorideCat. No.: HY-101251A

39、minopicoline (Ascensil) is a potent andnonselective inhibitor of NO synthase (NOS)isoenzymes (iNOS, nNOS, eNOS).AMT hydrochloride is a selective inhibitor ofinducible NOS (iNOS) with K of 4.2 nM.iPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Developmen

40、t ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/anemarsaponin-b.html Anemarsaponin HYPERLINK https:/www.MedChemE/anemarsaponin-b.html HYPERLINK https:/www.MedChemE/anemarsaponin-b.html B HYPERLINK https:/www.MedChemE/anemarsaponin-b.html HYPERLINK https:/www.MedChemE/ar-c102222-hydrochlorid

41、e.html AR-C102222 HYPERLINK https:/www.MedChemE/ar-c102222-hydrochloride.html HYPERLINK https:/www.MedChemE/ar-c102222-hydrochloride.html hydrochlorideCat. No.: HY-N0811 Cat. No.: HY-12122AAnemarsaponin B is a steroidal saponin.Anemarsaponin B decreases the protein and mRNAlevels of iNOS and COX-2.

42、Anemarsaponin B reducesthe expressions and productions ofpro-inflammatory cytokines, including TNF-a andIL-6.AR-C102222 hydrochloride is a potent, competitive,orally active and highly selective inducible nitricoxide synthase (iNOS) inhibitor, with an IC of 3750nM. AR-C102222 hydrochloride has antino

43、ciceptionand anti-inflammatory activities.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/asperuloside.html Asperuloside HYPERLINK https:/www.MedChemE/asperuloside.h

44、tml HYPERLINK https:/www.MedChemE/Asymmetric_dimethylarginine.html Asymmetric HYPERLINK https:/www.MedChemE/Asymmetric_dimethylarginine.html HYPERLINK https:/www.MedChemE/Asymmetric_dimethylarginine.html dimethylarginineCat. No.: HY-N1382 Cat. No.: HY-113216Asperuloside is an iridoid isolated from H

45、edyotisdiffusa, with anti-inflammatory activity.Asperuloside inhibits inducible nitric oxidesynthase (iNOS), suppresses NF-B and MAPKsignaling pathways.Asymmetric dimethylarginine is an endogenousinhibitor of nitric oxide synthase (NOS), andfunctions as a marker of endothelial dysfunctionin a number

46、 of pathological states.Purity: 99.69%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 20 mgPurity: 95.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/AVE-3085.html AVE3085 HYPERLINK https:/www.MedChemE/AVE-3085.html HYPERLINK https:

47、/www.MedChemE/bbs-4.html BBS-4Cat. No.: HY-19504 Cat. No.: HY-12124AVE3085 is a potent endothelial nitric oxidesynthase enhancer, used for cardiovasculardisease treatment.BBS-4 is a potent and selective inducible nitricoxide synthase (NOS2) dimerization inhibitor,with an IC of 0.49 nM. BBS-4 can pro

48、tect mice50from the cardiovascular dysfunction of sepsis.Purity: 99.95%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg, 10 mg, 20 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 50 mg, 100 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK

49、 https:/www.MedChemE/Bendazol.html BendazolCat. No.: HY-B2141 HYPERLINK https:/www.MedChemE/britannilactone-diacetate.html Britannilactone HYPERLINK https:/www.MedChemE/britannilactone-diacetate.html HYPERLINK https:/www.MedChemE/britannilactone-diacetate.html diacetate HYPERLINK https:/www.MedChemE

50、/britannilactone-diacetate.html (1,6-O,O-Diacetylbritannilactone;Di-O-acetylbritannilactone) Cat. No.: HY-N4190Bendazol is a hypotensive drug which can alsoenhance NO synthase activity in renal glomeruliand collecting tubules.Britannilactone diacetate(1,6-O,O-Diacetylbritannilactone; Compound 2)exhi

51、bits potential NO inhibition effect.Purity: 99.45%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/bryonolic-acid.html Bryonolic HYPERLINK https:/www.MedChemE/bryonolic-acid.html HYPERLINK https:/www.MedChe

52、mE/bryonolic-acid.html acid HYPERLINK https:/www.MedChemE/bryonolic-acid.html HYPERLINK https:/www.MedChemE/buddlejasaponin-iv.html Buddlejasaponin HYPERLINK https:/www.MedChemE/buddlejasaponin-iv.html HYPERLINK https:/www.MedChemE/buddlejasaponin-iv.html IVCat. No.: HY-N2965 Cat. No.: HY-125131Bryo

53、nolic acid is an active triterpenoid compoundwith immunomodulatory, anti-inflammatory,antioxidant and anticancer activities.Buddlejasaponin IV (BSIV) exertsanti-inflammatory and cytotoxic effects againstcancer cells.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical

54、 Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/camstatin.html Camstatin HYPERLINK https:/www.MedChemE/camstatin.html HYPERLINK https:/www.MedChemE/camstatin-tfa.html Camstatin HYPERLINK https:/www.MedChemE/camstatin-tfa.html HYPERLINK https:/www.MedChemE/camstat

55、in-tfa.html TFACat. No.: HY-P0184 Cat. No.: HY-P0184ACamstatin, a functionally active 25-residuefragment of PEP-19s IQ motif, binds calmodulinand inhibits neuronal nitric oxide (NO) synthase.Camstatin TFA, a functionally active 25-residuefragment of PEP-19s IQ motif, binds calmodulinand inhibits neu

56、ronal nitric oxide (NO) synthase.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/carboxy-ptio.html Carboxy-PTIO HYPERLINK https:/www.MedChemE/carboxy-ptio.html HYPERLINK https:/www.MedChe

57、mE/carboxy-ptio-potassium.html Carboxy-PTIO HYPERLINK https:/www.MedChemE/carboxy-ptio-potassium.html HYPERLINK https:/www.MedChemE/carboxy-ptio-potassium.html potassiumCat. No.: HY-18734 Cat. No.: HY-18734ACarboxy-PTIO is a potent nitric oxide (NO)scavenger that can make a quick reaction with NOto

58、produce NO . Carboxy-PTIO can prevent2hypotension and endotoxic shock through the directscavenging action against NO inlipopolysaccharide-stimulated rat model.Carboxy-PTIO potassium is a potent nitric oxide(NO) scavenger that can make a quickreaction with NO to produce NO . Carboxy-PTIO2potassium ca

59、n prevent hypotension and endotoxicshock through the direct scavenging action againstNO in lipopolysaccharide-stimulated rat model.Purity: 98%Clinical Data: No Development ReportedSize: 5 mgPurity: 98.36%Clinical Data: No Development ReportedSize: 5 mg, 10 mg HYPERLINK https:/www.MedChemE/carboxyebs

60、elen.html Carboxyebselen HYPERLINK https:/www.MedChemE/carboxyebselen.html HYPERLINK https:/www.MedChemE/Chondroitin_sulfate_.html Chondroitin HYPERLINK https:/www.MedChemE/Chondroitin_sulfate_.html HYPERLINK https:/www.MedChemE/Chondroitin_sulfate_.html sulfate(HOOC-Ebs) Cat. No.: HY-139448 (Chondr