Atractylenolide-III-ICodonolactone-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAtractylenolide IIICat. No.: HY-N0203CAS No.: 73030-71-4Synonyms: ICodonolactone; 8-Hydroxyasterolide分式: CHO分量: 248.32作靶點(diǎn): Apoptosis作通路: Apoptosis儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DM

2、SO : 100 mg/mL (402.71 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.0271 mL 20.1353 mL 40.2706 mL5 mM 0.8054 mL 4.0271 mL 8.0541 mL10 mM 0.4027 mL 2.0135 mL 4.0271 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備?/p>

3、，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (10.07 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (10.07 mM); Clear solution1/2 Master

4、of Small Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (10.07 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 術(shù)內(nèi)酯III(Atractylenolide-III)術(shù)根莖主要成分，有誘導(dǎo)肺癌細(xì)胞凋亡活性。REFERENCES1. Kang TH, et al. Atractylenolide III, a sesquiterpenoid, induces apoptosis in human lung carcinom

5、a A549 cells via mitochondria-mediateddeath pathway. Food Chem Toxicol. 2011 Feb;49(2):514-9.2. Wang KT, et al. Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and invivo. J Pharm Pharmacol. 2010 Mar;62(3):381-8.3. Kim HK, et al. Tox

6、icity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae andDermatophagoides pteronyssinus. J Agric Food Chem. 2007 Jul 25;55(15):6027-31.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820