Adoprazine-SLV313-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAdoprazineCat. No.: HY-14782CAS No.: 222551-17-9Synonyms: SLV313分式: CHFNO分量: 405.46作靶點: 5-HT Receptor; Dopamine Receptor作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mont

2、h溶解性數(shù)據(jù)體外實驗 DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 3 mg/mL (7.40 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 30 mg/mL (73.99 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Adopraz

3、ine是5-HT1A受體的完全激動劑和D2/3受體的拮抗劑。REFERENCES1. Auclair AL, Kleven MS, Barret-Grvoz C, Barreto M, Newman-Tancredi A, Depoortre R. Differences among conventional, atypical andnovel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys. Behav Brain Res. 2009 N2. Lang

4、e JH, Reinders JH, Tolboom JT, Glennon JC, Coolen HK, Kruse CG.Principal component analysis differentiates the receptorbinding profiles of three antipsychotic drug candidates from current antipsychotic drugs. J Med Chem. 2007 Oct 18;50(21):5103-8.3. McCreary AC, Glennon JC, Ashby CR Jr, Meltzer HY,

5、Li Z, Reinders JH, Hesselink MB, Long SK, Herremans AH, van Stuivenberg H,Feenstra RW, Kruse CG. SLV313 (1-(2,3-dihydro-benzo1,4dioxin-5-yl)-4- 5-(4-fluoro-phenyl)-pyridin-3-ylmethyl-piperazine monoh4. Feenstra RW, van den Hoogenband A, Stroomer CN, van Stuivenberg HH, Tulp MT, Long SK, van der Heyd

6、en JA, Kruse CG. SARstudy of 1-aryl-4-(phenylarylmethyl)piperazines as ligands for both dopamine D2 and serotonin 5-HT1A receptors showing varying degrees5. Cosi C, Carilla-Durand E, Assi MB, Ormiere AM, Maraval M, Leduc N, Newman-Tancredi A. Partial agonist properties of theantipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release. Eur J PhMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.T