Glycerol-Glycerin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGlycerolCat. No.: HY-B1659CAS No.: 56-81-5Synonyms: Glycerin分式: CHO分量: 92.09作靶點: Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 300 mg

2、/mL (3257.68 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 10.8589 mL 54.2947 mL 108.5894 mL5 mM 2.1718 mL 10.8589 mL 21.7179 mL10 mM 1.0859 mL 5.4295 mL 10.8589 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Glycerol透明，粘稠的甜味液體。油可

3、于聚丙烯酰胺凝膠電泳的樣品制備和凝膠形成。IC50 & Target Human Endogenous Metabolite體外研究Glycerol is often included in polyacrylamide gels to prevent dissociation of nucleosomes and other protein-1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEDNA complexes during electrophoresis. With glycerol included, fractionation se

4、ems to be largely based onparticle mass and charge. The concentration of glycerol during electrophoresis strongly affects the separationcharacteristics of polyacrylamide gels 1. Glycerol is an inevitable by-product of oils/fats processing,regardless of the pathway. Fermentative metabolism of glycero

5、l has been studied in great detail in severalspecies of the Enterobacteriaceae family, such as Citrobacter freundii and Klebsiella pneumoniae. The use ofanaerobic fermentation to convert abundant and low-priced glycerol streams generated in the production ofbiodiesel into higher value products repre

6、sents a promising route to achieve economic viability in the biofuelsindustry 2.體內(nèi)研究 Glycerol can induce acute renal failure in rat models. Acute renal failure induced by glycerol or uranyl nitratereduces the hepato-biliary transport of some drugs, modulates the distribution of drugs into the centra

7、lnervous system and affects the activity of various hepatic microsomal enzymes 3.PROTOCOLAnimal Rats: Experimental acute renal failure was induced in male Wistar rats 230-300 g by an injection of glycerolAdministration 3 dissolved in saline (50% v/v, 10 mL/kg) into the leg muscle after a 24-h period

8、 of water deprivation 3.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gelelectrophoresis. Nucleic Acids Res. 1992 Dec

9、25;20(24):6667-72.2. Yazdani SS, et al. Anaerobic fermentation of glycerol: a path to economic viability for the biofuelsindustry. Curr Opin Biotechnol. 2007Jun;18(3):213-9.3. Huang ZH, et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 Oct20;406(3):453-60.McePdfHeightCaution: Product has not been fully validated for med