S-plus-Ketoprofen-S-Ketoprofen-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemES-(+)-KetoprofenCat. No.: HY-B2137CAS No.: 22161-81-5Synonyms: (S)-Ketoprofen; Dexketoprofen分式: CHO分量: 254.28作靶點(diǎn): COX作通路: Immunology/Inflammation儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMS

2、O : 125 mg/mL (491.58 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.9327 mL 19.6634 mL 39.3267 mL5 mM 0.7865 mL 3.9327 mL 7.8653 mL10 mM 0.3933 mL 1.9663 mL 3.9327 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，

3、再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (8.18 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (8.18 mM); Clear solution1/2 Master o

4、f Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (8.18 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 S-(+)-Ketoprofen是COX-1 和 COX-2 的有效抑制劑，IC50 值分別為 1.9 和 27 nM。IC50 & Target COX-1 COX-213 M (IC50) 370 M (IC50)體外研究 S-(+)-Ketoprofen (Compound 1) is a potent i

5、nhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM,respectively 1.REFERENCES1. Palomer A, et al. Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity ofketoprofen analogues. JMed Chem. 2000 Jun 1;43(11):2280-4.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5