Sulconazole-nitrate-racemic-Sulconazole-nitrat-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESulconazole nitrateCat. No.: HY-B1460ACAS No.: 82382-23-8Synonyms: ()-Sulconazole nitrat分式: CHClNS . HNO分量: 460.76作靶點(diǎn): Fungal作通路: Anti-infection儲存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fro

2、mlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 27 mg/mL (58.60 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.1703 mL 10.8516 mL 21.7033 mL5 mM 0.4341 mL 2.1703 mL 4.3407 mL10 mM 0.2170 mL 1.0852 mL 2.1703 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性

3、 Sulconazole nitrate種咪唑類的抗真菌(antifungal) 試劑。IC50 & Target Antifungal 1 2體內(nèi)研究After cutaneous application of radioactive solutions of Sulconazole nitrate in the hairless rat, the totalabsorption of the substance by the skin, estimated from the sum of the cumulative urinary and fecal1/2 Master of Small

4、 Molecules 您邊的抑制劑師www.MedChemEexcretions over 96 h, is 2.4% of the dose administered. The elimination reaches a maximum between 6 and24 h and is virtually complete after 96 h. The excretion is almost equally distributed between the urine andthe feces, which corresponds to an intense elimination via

5、the biliary tract. The quantities present in thestratum corneum, epidermis and dermis at the end of the period of contact constituted another estimation ofthe total absorption of the substance which confirmed the previous estimation (3.6% of the dose). Themeasurement of the concentrations of Sulcona

6、zoleand its metabolites in the various layers of the skinreveals a high affinity of the substance for the stratum corneum, where it remains present in large quantitiesfor more than 48 h. This affinity is due to the very intense lipophilia of the molecule. The concentrations in theother tissues are i

7、nversely proportional to the distance from the surface of the skin and are virtually nil in thecirculating blood 3.REFERENCES1. Zaro BA, et al. Species variation in percutaneous absorption of sulconazole nitrate, a new anti-fungal agent. Proc West Pharmacol Soc.1982;25:357-9.2. Bielejewska A, et al.

8、 Effect of (+) or (-) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugson a Chiralcel OD column. J Chromatogr A. 2005 Aug 12;1083(1-2):133-40.3. Hercelin B, et al. Pharmacokinetics of cutaneous Sulconazole nitrate in the hairless rat: absorption, excretion, tissue concentrations. EurJ Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):149-54.McePdfHeightCaution: Product has not been fully validated for medical applicat