SU6656 - Src 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESU6656Cat. No.: HY-B0789CAS No.: 330161-87-0分式: CHNOS分量: 371.45作靶點: Src作通路: Protein Tyrosine Kinase/RTK儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 18.5 mg/mL (49.80 mM; Need ultrasonic

2、and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.6922 mL 13.4608 mL 26.9215 mL5 mM 0.5384 mL 2.6922 mL 5.3843 mL10 mM 0.2692 mL 1.3461 mL 2.6922 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 SU6656是Src 家族激酶抑制劑，抑制 Src，Yes，Lyn，F(xiàn)yn 的IC50分別為 280，20，130，170 nM。體外研究

3、SU6656 decreases phosphorylation of Src family kinases (SFKs) in HNSCC cells 2.體內(nèi)研究SU6656 (2-4 mg/kg; i.p.; once) significantly decreases ischemic postconditioning (IPoCo) mediated increasein fall down time 5.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEAnimal Model: Swiss albino male mice 5Dosa

4、ge: 2, 4 mg/kgAdministration: Intraperitoneal injection; onceResult: Significantly decreased IPoCo mediated increase in fall down time.戶使本產(chǎn)品發(fā)表的科研獻 Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3824-3836. bioRxiv. 2019 May.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1.

5、Blake RA, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000Dec;20(23):9018-27.2. Veracini L, et al. Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and necksquamous cell carcino

6、mas. Oncotarget. 2014 Dec 26.3. Wu ML, et al. Divergent signaling pathways cooperatively regulate TGF induction of cysteine-rich protein 2 in vascular smooth musclecells. Cell Commun Signal. 2014 Mar 28;12:22.4. Ondrusov L, et al. Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, i

7、s not accompanied by activation of Akt/PKBsignalling in melanoma cells. Folia Biol (Praha). 2013;59(4):162-7.5. Kumar A, et al. Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemicpostconditioning in mice. Int J Neurosci. 2014 Oct;124(10):777-86.6. Liu XF, et al. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Mol CancerTher. 2014 Jan;13(1):82-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For re