AM-92016-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAM-92016 hydrochlorideCat. No.: HY-101253CAS No.: 133229-11-5分式: CHClNOS分量: 483.84作靶點(diǎn): Others作通路: Others儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 260 mg/mL (537.3

2、7 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.0668 mL 10.3340 mL 20.6680 mL5 mM 0.4134 mL 2.0668 mL 4.1336 mL10 mM 0.2067 mL 1.0334 mL 2.0668 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬?chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清

3、的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (4.48 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (4.48 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.17 mg

4、/mL (4.48 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 AM 92016 (hydrochloride)種特異性 IK 抑制劑。AM 92016 (hydrochloride) 延遲整流鉀通道 (IK)，使膜復(fù)極化從限制神經(jīng)沖動(dòng)的持續(xù)時(shí)間。 AM 92016 (hydrochloride) 延長了豚和兔分離的室細(xì)胞的臟動(dòng)作電位持續(xù)時(shí)間，IC50 值為 30 nM。REFERENCES1. ConnorsSP,etal.Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbitventricular cells. Br JPharmacol. 1992 Aug;106(4):958-65.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>