Nisoldipine-BAY-k-5552-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENisoldipineCat. No.: HY-17402CAS No.: 63675-72-9Synonyms: BAY-k 5552分式: CHNO分量: 388.41作靶點: Calcium Channel; Reactive Oxygen Species作通路: Membrane Transporter/Ion Channel; Neuronal Signaling;Immunology/Inflammation; Metabolic Enzy

2、me/Protease; NF-B儲存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (257.46 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.44 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small

3、 Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.44 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Nisoldipine(BAY-k 5552; Sular)效特異的L型Cav1.2通道阻斷劑，IC50為10 nM。REFERENCES1. Hamilton SF, Houle LM, Thadani U. Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina,

4、andheart failure. Heart Dis. 1999 Nov-Dec;1(5):279-88.2. Fodor JG. Nisoldipine CC: efficacy and tolerability in hypertension and ischemic heart disease. Cardiovasc Drugs Ther. 1997 Jan;10Suppl 3:873-9.3. D.J. Duncker, J.M. Hartog, P.G. Hugenholtz, et al. The effects of nisoldipine (Bay K 5552) on ca

5、rdiovascular performance and regionalblood flow in pentobarbital - anaesthetized pigs with or without -adrenoceptor blockade. British Journal of Pharmacology. 1986,88(1): 9-184. Jan W. De Jong, Tom Huizer, Jan G.P. Tijssen. Energy conservation by nisoldipine in ischaemic heart. British Journal of Pharmacology.1984, 83(4): 943-949McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0