Aztreonam-SQ-26-776-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAztreonamCat. No.: HY-B0129CAS No.: 78110-38-0Synonyms: SQ-26,776分式: CHNOS分量: 435.43作靶點: Bacterial作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 50 mg/mL (114.83 mM; Nee

2、d ultrasonic)H2O : 10 mg/mL (22.97 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.2966 mL 11.4829 mL 22.9658 mL5 mM 0.4593 mL 2.2966 mL 4.5932 mL10 mM 0.2297 mL 1.1483 mL 2.2966 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為

3、保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.74 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.74 mM); Clear solution1/2 Master of Small Mole

4、cules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.74 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Aztreonam (SQ-26)單環(huán)-內(nèi)酰胺抗素，與 霉素結(jié)合蛋3（PBP-3）有較親和。IC50 & Target Penicillin-binding proteins 3 (PBP-3) 1.體外研究 Aztreonam (SQ-26) is a synthetic monocyclic beta-lactam antibioti

5、c (a monobactam), with the nucleus basedon a simpler monobactam isolated from Chromobacterium violaceum. It was approved by the U.S. Food andDrug Administration in 1986. It is resistant to some beta-lactamases, but is inactivated by extended-spectrumbeta-lactamases. Aztreonam has no useful activity

6、against gram-positive or anaerobic microorganisms 1.Aztreonam (SQ-26) is similar in action to penicillin. It inhibits mucopeptide synthesis in the bacterial cell wall,thereby blocking peptidogly can crosslinking. It has a very high affinity for penicillin-binding protein 3 (PBP-3)and mild affinity f

7、or PBP-1a. Aztreonam (SQ-26) binds the penicillin-binding proteins of gram-positive andanaerobic bacteria very poorly and is largely ineffective against them. Aztreonam (SQ-26) is bactericidal butless so than some of the cephalosporins 2.戶使本產(chǎn)品發(fā)表的科研獻 Antimicrob Agents Chemother. 2018 Jul 27;62(8). pi

8、i: e00414-18. Biomed Res Int. 2018 Jul 2;2018:3579832.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Kobayashi Y, et al. Synergy with aztreonam and arbekacin or tobramycin against Pseudomonas aeruginosa isolated from blood. JAntimicrob Chemother. 1992 Dec;30(6):871-2.2. Guay DR, et al. Aztreonam, a new monobactam antimicrobial. Clin Pharm. 1985 Sep-Oct;4(5):516-26.McePdfHeightCaution: Product has not been fully validated for medical applica